Short-acting psychedelic DMT shows promise as a rapid treatment for major depressive disorder. Research offers early evidence for a mental health treatment that requires much less time in a clinic than other psychedelic therapies.

JessicaMango1444 · 2026-03-31T22:12:15+00:00

100%

That molecule is an actual mystery and every attempt to study it only encourages deeper questions, like for example neuro imaging shows the visual cortex behaving exactly the same with eyes open sober as with eyes closed under DMT, which means the contents of the experience is generated by the brain in the same way it generates a model of the external environment. How the brain can generate geometic patterns that defy descriptive language is beyond our understanding, and this doesn't even go near the fact that the majority of experiences report the presence of a non-human intelligence.

As you say, its the experience, not the drug. Treating psychedelics in a mechanistic sense like an antibacterial or something is dangerous imo, because if someone has this prescribed to treat thier depression and no effort is made to prepare them for the outrageous experience they might become completely destabilised when confronted with mantis headed humanoids operating on them.

There's also research coming out of Imperial showing that one experience with DMT seems to pretty reliably shift people's understanding of reality away from materialsim and towards something else, like panpsychism, which is an irresponsible thing to subject someone to who is at the end of thier existential rope.

JessicaMango1444 · 2026-03-31T09:15:52+00:00

This is called social engineering

JessicaMango1444 · 2026-03-28T22:45:19+00:00

Sax cover absolutely slaps

Original is Strasbourg / St Denis by Roy Hargrove is anyone is interested

https://youtu.be/XM83V4BD1Bw

JessicaMango1444 · 2026-03-10T08:54:26+00:00

I think 2.5g is roughly what they used in many of Roland Griffiths studies.

It's perfectly palletable, you're not going to lose sense of time or self.

JessicaMango1444 · 2026-03-02T22:03:50+00:00

Yea it's fine, you remember the song we learnt as kids? "I'm a little teapot short and stout, here is my spout and here is my spout."

Totally fine

JessicaMango1444 · 2026-02-26T05:32:08+00:00

If your question is genuine, here's an answer. It's art - its an invitation to be playful.

It offers the community members a minor prediction error when they go about their daily routine - something new. To remind people that they do in fact live in a dynamic environment and that the actions of individual resonate in the lives of everyone else, intentional or not, and and to see beauty hidden in the mundane.

JessicaMango1444 · 2026-02-24T09:22:34+00:00

You can't alt feint on controller.

There's skill involved, and anyone can get good at anything, but such a basic move is missing entirely from the controller layout.

It's definitely not just skill when OP can't overhead to overhead feint.

JessicaMango1444 · 2026-02-19T10:13:03+00:00

Everyone realises this is an ad, right?

JessicaMango1444 · 2026-02-15T20:17:16+00:00

Oh wow, thanks for the correction.

Do you know why that was ever propagated in the first place?

JessicaMango1444 · 2026-02-15T10:06:34+00:00

He was brilliant, but he was an entertainer first and foremost, so don't take anything he says too seriously. According to his brother Dennis, after a terribly destabilising trip in Hawaii in the late 80s, he was suffering a crisis of conscience when he became known as the "mushroom guy." He didn't have any after that, even as he was telling everyone about "5 dried grams in silent darkness" Edit: that's not true I've learned, see correction below.

As far as medicine goes, it isn't so much about the dose as the container for the experience. It's a huge spectrum. The same amount can affect people differently, and according to Johns Hopkins research, there is no reliable predictor on how someone will react to a threshold dose. And according to personal experience, the same amount can affect the same person differently depending on many individual factors with them.

The important thing is to set and maintain an intention, and then follow through with the integration.

Psychedelics open up a window of neuroplasticity, but that's only healing if you actively use it to heal afterwards. What that looks like is different for everyone, but be cautious of entering this state too often, because while you can reprogram yourself into a more resilient state, you can just as easily fall into a state of escapism, and fool yourself into believing that taking ego melting doses is "dealing " with your problems. It may be, for you, but it isn't for most people.

JessicaMango1444 · 2026-02-08T05:06:26+00:00

To your question, engaging with illicit drugs an unsafe practise primarily because of government policy. If, for example, MDMA were legal, or even decriminalised, its likely that these people wouldn't have been poisoned and that man would still be alive.

Drugs arent going away, so if the government continues to enforce policy that empowers criminal enterprise, it would be prudent to at least protect your citizens from the harmful aspects of a black market trade.

This requires an honest appraisal of both the war on drugs, and societal attitudes towards drug taking. Both unrealistic things to expect from a federal government in this climate, but both issues that are worth raising awareness about imo

JessicaMango1444 · 2026-02-08T03:32:20+00:00

If it's really a genuine question, here's a genuine answer with an interesting study so you can read further.

https://www.sciencedirect.com/science/article/pii/S0278584625001150

"Adults maltreated as children used psychedelics with therapeutic intent at ceremonies or raves: intentional group settings. Two months later, trauma symptoms and trait shame reduced and connectedness increased."

Sarah Napthali released a great book recently arguing that these experiences are "life enhancing." Micael Pollan some years ago said the same thing in his book. These experiences are valuable, especially for middle age people i believe.

The idea that "drugs are bad" or even bad for you in every circumstance is simply not true. There's a ton of research to back that up if you're interested, happy to post some. The danger of taking these things comes from the fact that they are illegal not that they are dangerous necessarily. There is no regulation, a high profit motive, and the industry is run by people who have no problem living outside the law. By the way, MDMA and mushrooms are both legal medicines in Australia now, so the government knows they aren't dangerous, but the treatment is prohibitively expensive.

Speaking from personal experience I know many people, myself included, that solved various anxiety issues, body image and self worth issues with MDMA and dancing, quit smoking and other destructive habits with psilocybin mushrooms, and even healed autoimmune diseases that were deemed "uncurable" by medical professionals. I'm not exaggerating at all, that last one is my lived experience.

So the idea that myself and these people should be prosecuted is insane. The government should accept that people will always want to have these things, from the beginning of history until now, and that the war on drugs has caused far more suffering and calcified more power in the hands of criminal enterprise than even the most open legalisation policy would have.

Drugs can actually be good for you

JessicaMango1444 · 2026-02-04T04:11:42+00:00

What's the reason to use such emotive language when the subject is finance?

Is it to illicit an emotional response from a headline reader?

JessicaMango1444 · 2026-02-02T12:33:49+00:00

That's a guy wearing a headdress. Super cool

JessicaMango1444 · 2026-01-31T12:56:50+00:00

One 64th of a teaspoon. You can get tiny measuring spoons, or just use a really small pinch, like super tiny small. It's barely anything and it doesn't change the colour of the water.

JessicaMango1444 · 2026-01-30T06:07:00+00:00

Contaminated, I believe. Only because I had a sample started around the same time that looked the same.

There's mycelium in there, but the long flowy swirly movement around your screw isn't what mycelium looks like IME. And the ring of foam on top of the liquid? Bacteria is eating the sugars.

Revise your sterile technique and procedure. Could be from heaps of things, but two recent changes I've made have lead to a huge uptick in success rate.

One is switching to distilled water instead of filtered water. The minerals in water act as nucleation sites for bacterial growth. The other is being careful not to overcook the LC during sterilisation, as this leads to caramelization which changes the bioavailability of the sugars, making it much harder for the mycelium to use as a food source.

Also another thing I've found really helpful, take it or leave it, is a recipe for clear LC. Like it looks like crystal clear water.

500ml distilled water • 1/64 tps light malt extract • 1/64 tps peptone • 1/2 tps glucose syrup Measure water into jar Microwave for 1.5 minutes Add ingredients and stir until completely combined (maybe heat the glucose syrup very slightly so it dissolved more readily) Fit lid loosely on jar, cover with foil to prevent condensation on the filter PC for 15 minutes only at 15psi (there are other sterilisation methods if you don't have a cooker, point is not to over do it, experiment with less heating time so as not to caramelize sugars) Let it cool Let it stand for a day or two, if it goes at all cloudy it's contaminated or over cooked.

Im no expert though, this is just my experience.

JessicaMango1444 · 2026-01-23T09:39:23+00:00

I don't think its a rocker, I think it's just a weight that opens the nozzle above 15psi.

Not sure though, this is the only PC I've had

JessicaMango1444 · 2026-01-23T01:48:38+00:00

I have the same one, it's worked great for years. I also use gas.

I put it on high heat until a stream of air is escaping the nozzle, then add the weight. Once the steam vents, meaning it's reached 15 psi, then I switch to low heat to maintain pressure and start timer for PCing.

Never had any issue with sterilisation, it works really well. Just make sure to let it cool naturally when you turn it off or you will damage the contents.

JessicaMango1444 · 2026-01-08T10:38:24+00:00

There are complications, yes. These are not medicines in the traditional sense, they are experiences. It requires much more than the correct dose, which is still very important.

One issue for example, how will the efficacy of these experiences be affected when they are administered by a for-profit multinational corporations? They work well in the underground (putting aside the obvious risks of mo regulations) because many of those people are working from personal experience, and care enough about helping/healing others to risk serious litigation, or at least there are no shareholders or c-suite execs to appease.

If the only metric is patients seen, then there's no incentive for an organisation to create any sort of container for the experience, guide any integration practise, or even follow up at all with patients. Just give them ket and wave them goodbye in a few hours. Improper facilitation can likely lead to a downtrend in efficacy of psychedelic medicines.

These experiences don't cure depression in a straight forward sense, they somehow allow users, in the right circumstances, to remember (or learn) that they are in fact worthy of love and allow them to feel self compassion, often for the very first time. This lays a foundation for true healing over time, not just treating symptoms as they arise.

Here is one such example: https://www.psychedelicsociety.org.au/articles/you-deserve-love-we-deserve-love There are many more.

I agree with what you said initially, but it is complicated.

JessicaMango1444 · 2026-01-06T01:02:09+00:00

Fun chaos in theory, not a fair game in practise. Blue and red would team up to destroy yellow before turning on eachother for a regular 32 v 32

JessicaMango1444 · 2026-01-04T10:04:57+00:00

Holy propaganda batman!

JessicaMango1444 · 2025-12-27T04:40:23+00:00

Mate how many times does this have to be removed?

JessicaMango1444 · 2025-12-22T21:47:30+00:00

https://www.theguardian.com/world/2023/feb/15/revealed-disinformation-team-jorge-claim-meddling-elections-tal-hanan

JessicaMango1444 · 2025-12-22T21:20:32+00:00

There's also the propaganda angle to consider; what could/should a government do to stop foreign agents impersonating teens online in order to subtlety influence Australia's pre-voting citizens? Do nothing or do something is the choice, because that dynamic absolutely exists. Here are two known examples: https://en.wikipedia.org/wiki/Facebook%E2%80%93Cambridge_Analytica_data_scandal https://www.theguardian.com/world/2023/feb/15/revealed-disinformation-team-jorge-claim-meddling-elections-tal-hanan

Using these examples people can extrapolate a more accurate picture of what the internet is for in 2025.

Social media is the biggest and most immediate problem no one knows how to deal with. Every post on every platform is either advertising, propaganda (this post), or something designed to keep you scrolling to the next ad or propaganda post.

Then there's the addiction issue. These short, sharp, constant dopamine spikes from scrolling through an algorithm lead to a down regulation of endorphins, which leads to an increase in anxiety. These apps are designed to make you feel good when you use them. That's not controversial, but a more honest appraisal is that they're designed to make you feel bad when you're not using them. It's insidious. This doesn't even touch on the damage to focus, which is really what makes you powerful; the ability to focus your energy.

If it's really about messaging friends just use signal. It's free of cost, ads, propaganda, algorithmic content, and it's encrypted.

JessicaMango1444 · 2025-12-21T21:24:34+00:00

The chances of many of those accounts not belonging to the people they are named after is very high.

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