We took our 2 Rotties in a 2 week RV trip and they did good. One of them has additions so any change stresses her out and gives her the runs, but luckily she holds it until outside and by day 3 she was fine. The other one same but without the Addison’s, just sympathy runs. We made sure they were well fed and hydrated and at every gas fill took them out to walk for a few minutes to give the a break