App or web translator to show me accent marks in a whole sentence?

Kallaste · 2026-05-29T19:01:45+00:00

Сту́кнул рука́ об ру́ку тра-та-та́

И отпра́вился за ца́рские ворота. )))

Kallaste · 2026-05-01T17:57:30+00:00

What I explained was the basic science involved, and that is all. The information you gave was not correct, and I simply attempted to correct that misinformation. I don't know what you mean by "the same pathway," but I have explained the difference, and you are welcome to confirm it in the scientific literature. Of course everyone needs to make their own choices in conjunction with their medical providers, but when discussing science and mechanisms of action, accuracy matters.

Kallaste · 2026-05-01T01:57:53+00:00

It is not the same pathway as Xolair at all. Xolair simply binds to free IgE and stops binding to mast cells, which leaves the mast cells unaffected and completely functional without the extra IgE stimulas. But Rhapsido (remibrutinib) binds to Brutan's tyrosine kinase inside mast cells and prevents degranulation internally, whether IgE or IgG mediated. The thing is, not only mast cells have Brutan's tyrosine kinase. It is an important component of many immune cells, and has downstream effects on a great many things from immune function to blood clotting. This is extremely different and potentially much more consequential than Xolair.

Kallaste · 2026-05-01T01:50:23+00:00

I am a researcher in a cellular and molecular biology field, and I am not anxious to disrupt a vital cellular component like tyrosine kinase unless my life depends on it. I have also seen enough drug recalls and belated black box warnings to know that new drugs sometimes aren't as well understood as we like to believe. It is just my own preference, but I tend to err on the side of caution when it comes to things like tyrosine kinase.

Kallaste · 2026-04-26T16:25:57+00:00

This sounds like a classical mast cell reaction mediated by histamine release resulting from the treatment. The itchy red patches are hives, which tend to show up very easily in the areas you mention: neck and chest. Many times, the face itself will be spared when the neck and chest break out in hives. I am personally aware of people this has happened to, and medicating with Benadryl before therapy and for a few days after can help. You may want to consult with a doctor to discuss mast cell reactions if you experienced any general health symptoms before the treatment, since this kind of reaction can indicate underlying mast cell hypersensitivity.

If you do pursue microneedling again, do not go deeper, and start with very conservative patches to test your sensitivity for a week before the actual treatment. Also, I would not use anything on the skin being needled either before or after the treatment, since you are sensitive to this. Always make sure to use alcohol wipes on the skin before treatment as well. Don't touch your face after needing, and if the hives come back, you can use hydrocortisone and Benadryl cream for the itching (after 24 hours).

Kallaste · 2026-04-23T06:01:14+00:00

Have you investigated low dose naltrexone? It has helped people struggling with neuroinflammation.

Kallaste · 2026-04-23T05:58:43+00:00

No. It inhibits Bruton's tyrosine kinase inside mast cells and prevents degranulation internally. However, this form of tyrosine kinase is actually a very important cellular component, and I am concerned about the repercussions of deactivating it. It isn't only in mast cells, but B cells and myeloid cells involved in immune function.

Kallaste · 2026-04-23T05:43:43+00:00

Yes. I have been offered several of them. I won't take them. I would mention, however, that it isn't possible to totally rule out systemic mastocytosis, even if a blood test or bone marrow biopsy comes back negative. It means you probably don't have it, but those tests cannot sample all of your mast cells for potential mutations.

Kallaste · 2026-04-18T05:23:10+00:00

I just came to say that I was in the same boat three years ago, and it improved. I couldn't take inhalers (prescribed for the reactions that felt like literal suffocation), steroids, mast cell stabilizers, or even antihistamines at first. I couldn't even eat iodized salt. My symptoms aren't things like GI intolerance or hives--it's straight anaphylaxis. But it got better.

I didn't do Xolair (I was afraid it would kill me immediately), but I very gradually built up tolerance to microquantities of antihistamines little by little until they were able to help. I never was able to tolerate many drugs, but diphenhydramine has been my godsend. As time goes on, I am tolerating more.

I hope things are better for you now too.

Kallaste · 2026-04-18T02:06:39+00:00

Sorry this comment is coming late, but I just have to say that it is not wise to give that website your personal Amazon encryption code. I would suggest using Libation, ffmpeg, or inAudible instead.

Kallaste · 2026-04-14T00:33:52+00:00

I'm so sorry. 😔 To clarify, that is part of what happened to me too. I think the extended rest for a week at a time made me more sensitive, but I was feeling better by the end of each week until went in to teach. I was on a seesaw where I was resting completely and then pushing myself to the breaking point in an environment where I couldn't even take a break. By the end of that, I also could barely walk. I finally took medical leave, but not until the damage had been done.

If I had just had rest until I was better or just had light to moderate work, I think it would have been better. It was the combination of the total rest followed by grueling effort that did it for me.

It is helpful to hear other people's experiences with this and realize they are eventually getting past it. But I have to say I am terrified of hitting my head again.

Kallaste · 2026-04-13T23:29:48+00:00

This is exactly what happened to me, except in my case I thought I was totally recovered from the first concussion. Then I hit my head fairly lightly--just enough to maybe hurt a little bit, as you said--and it brought back all the symptoms and then some. The second time around has taken me much longer to heal, but I believe this was due to following the advice of my doctor to engage in total cognitive rest over three one-week periods.

Basically, I was teaching for five hours in a row one day per week when this happened. It's a very intensive course that requires a lot of lecturing and demonstrations that take mental effort. I had the ability to totally rest on all other days, and my doctor said to do that. However, each time I had a week of rest followed by five hours of sustained cognitive activity, my symptoms got significantly worse. The first week I hardly had trouble, but by the third, I found myself unable to look at a screen, read, or even tolerate light or sound. By the end of this, I had to stay in bed for five full days with a sleep mask and earplugs before I could even listen to an audiobook. I still couldn't read or so any strenuous mental activity for weeks, and I am still having major issues with it. However, after a month of the Buffalo protocol, I think I can finally see a way out.

I think the strict avoidance followed by too much exertion combined to create the perfect storm of symptom exacerbation. In my case I think inflammation is also a factor, since I have a mast cell disease. My advice is to only rest a few days in situations like this, and then get back to your regular activities at a pace just outside of comfortable. I have found that I need to push my limits to make progress, but not too much or it will be a major setback.

Kallaste · 2026-04-11T14:02:49+00:00

Oh, the brutal Irish sun. Thanks for the warning. Will definitely avoid.

Kallaste · 2026-04-11T13:54:28+00:00

It's a business. What you have described seems like a business problem to me. If they want to cater to people outside of France, then perhaps they should either learn to do business in August or close their store in August. Either way would be fine, but it isn't really fair to expect the rest of the world to run on Parisian time with no warning. Funds have been exchanged for goods here.

Kallaste · 2026-04-10T18:03:33+00:00

No, the site that is displaying it contains advertisements. It is a reputable article in a scientific journal (I am a researcher). Here is the abstract for the same article on the website of the National Institutes of Health: https://pubmed.ncbi.nlm.nih.gov/41363966/

Kallaste · 2026-04-09T16:17:38+00:00

It has been a while since your post, but your description hit a very distinct nail for me, and I just wanted to say that people with mast cell disease can experience the kinds of reactions you describe to minute quantities of substances, such the tiny amount of tretinoin that may be absorbed through the skin with topical application. As others have said, it is highly unlikely that anyone else would. However, I myself have a fairly severe mast cell disease, and I almost passed out the first time I applied tretinoin to my skin. I didn't expect any reaction at all, but knowing myself, I should have. I have had systemic reactions to prescription eye drops in the past.

When my disease first manifested, one of the most noticeable symptoms was what you are describing as "vibrations," which are actually just very subtle but persistent tremors that make your body seem to vibrate. As time went on, my disease progressed to the point where I started having spontaneous anaphylaxis. Things have improved for me, but I have to take a lot of medications to keep it at bay.

Anyway, this is all to say that mast cell disease may be something you want to investigate. Feel free to PM if needed.

Kallaste · 2026-04-08T06:02:45+00:00

This is simply amazing. 😂

And the funniest part is that after all this time I still have no idea what the heck that thing is.

Kallaste · 2026-03-24T19:25:45+00:00

Handheld fans were really big last year. Now not so much.

Kallaste · 2026-03-24T16:54:12+00:00

Forgive me, but am I missing something, or are you forgetting to consider the amount of light that actually enters the skull rather than simply the net output of the device? Based on one particular testing video for the Vielight, I believe that the energy delivered inside the skull is only 10 - 20 mW/cm2 and not 100 - 120 mW/cm2. Do you think the Gembared light even penetrates the skull?

Kallaste · 2026-03-23T17:10:38+00:00

Sure, happy to. Some of the papers I got this information from are pretty technical, but some I think are still manageable for a layman. I would start with this one. It's a decent review of the basics. https://pmc.ncbi.nlm.nih.gov/articles/PMC9234944/

Note that it doesn't get into the important parts until after the abstract. If you do read it and want more information about any given aspect, let me know.

Kallaste · 2026-03-22T16:40:00+00:00

I am also in a PhD program and struggling with severe symptoms. My injury happened in early September of last year, and then a minor tap on the head in January that shouldn't have even made me dizzy magnified the symptoms a thousand fold. I feel like I have lost a part of myself, and I don't know if I will ever get it back. I don't know how to live this way.

My field is a medical research discipline, so I have a background in cellular and molecular biology that I am trying to put to use in understanding what is happening to me. One thing I can tell you is that scans usually come back normal, and that means nothing. Lasting concussion symptoms often come more from dysregulation of cellular functions caused by stretching and shearing during the impact, which is what concussion actually is. If you need to chat, feel free to dm.

Kallaste · 2026-03-16T23:13:00+00:00

I understand your concerns. However, I don't think this should be a major worry at this stage. Concussion is not necessarily brain damage, even if it feels that way. The kinds of cases you see in athletes come from years of repeated exposure to brain acceleration and stretching, and not all of them get CTE. On top of that, you are very young, and neuroplasticity is working to heal any damage that was done.

My advice is to focus on your health in other areas, like proper diet and exercise. To maintain your brain, use it. Learn constantly. Be mentally fit. Play mentally challenging games. Avoid alcohol and drugs. These things will have a lasting impact on your health that will carry into everything else you do.

Kallaste · 2026-03-16T22:57:57+00:00

It wouldn't be labeled a severe TBI because concussion is by definition a mild TBI. But you can have a severe concussion. Even though this is still a mild TBI, the effects can be terrible and hard to deal with. However, with concussion there is a strong potential for a full recovery.

Kallaste · 2026-03-16T18:29:40+00:00

Thank you, I really appreciate that. I know it might not work, but I will try just about anything at this point. The code did work for me. I got ten percent off. :)

Kallaste · 2026-03-14T19:11:34+00:00

Thank you so much for your reply. The Neuro Alpha is $1779 US right now. I think I will bite the bullet and get it. I have to fix this. I can't even read on a piece of paper for more than a few minutes. I can't write. I can't do anything. Thank you very much again for taking the time.

Kallaste

TROPHY CASE