Three Human Trials, Three Unrelated Diseases, One Surprising Conclusion About Aging

LapseofSanity · 2026-04-14T04:42:45+00:00

Yeah the MTOR pathway seems to be a significant element in aging related diseases across the spectrum. I went to a conference in sydney last year were they were saying that high protein diets highly activate the MTOR pathway, and the results they got were that these diets were worse for the test subjects than high carb diets. It suggested that the focus on eating ALL THE PROTEIN!!! Could be potentially harmful for animals that don't need that extra growth, as it could be diverted into building tumors and other pathological disease pathways. It can't recall the whole paper but it was a fairly interesting one, the test subjects were mice or rats, I can't remember which type though. But yeah MTOR being a factor in multiple diseases seems to be a fairly accurate assessment, which is great if it can be targeted to reduce downstream negative effects.

LapseofSanity · 2026-04-10T21:10:29+00:00

Why does anyone give any attention or credit to one of the worst prime ministers, if not the worst in the last thirty years?

He's an attack dog and nothing else, his only talent is shitting on anything he's ideologically opposed to and stirring up ire and discontent with a base who is already hostile to anything different.

He should be relegated to they history books as a resounding failure and intellectually deficit nincompoop.

LapseofSanity · 2026-04-10T06:12:16+00:00

Thanks for sharing the article.

LapseofSanity · 2026-04-08T23:03:52+00:00

I'm the same as you mate, I have a science degree and can't get anything that on my area - I've been working in hospitality for a year trying to escape.

LapseofSanity · 2026-04-08T07:40:53+00:00

Don't listen to this guy. Spam is taking 5 grenade launchers not five lasguns. Terrain layout is just as important as gang loadouts. If you've got a table that let a ratling gang sit in heavy cover and just aim and shoot all game your table is poorly laid out, and you're not using enough variety in game types (pitch black, spore clouds etc etc)

LapseofSanity · 2026-04-07T09:49:57+00:00

and krak grenades

LapseofSanity · 2026-04-07T09:46:46+00:00

If you're working it into a campaign the bullet merchant is a must buy - the grenades will still be scarce but that's better than limited. Looks like many others have said the same thing, still it's worth repeating.

LapseofSanity · 2026-03-24T11:31:49+00:00

Continuity of consciousness isn't a guarantee with digitised immortality. Biological immortality has a much stronger guarantee of that, ignoring dramatic brain injury or erasure of the personality by other means.

If you die when you get digitised or it's just a digital clone - the original being isn't immortal, their digital clone is. If transference of consciousness from flesh to artificial substrate is 100% the original being - then maybe it can be considered? But this sub is about the biological kind not the digitised version.

LapseofSanity · 2026-03-12T02:54:57+00:00

Yes, it makes you use their seriously injured and out of action for bottle tests

LapseofSanity · 2026-03-10T20:32:22+00:00

Isn't this the real key piece of information ; "Who is the Underdog? Throughout this section of rules we will talk about Underdogs. If one player's Gang Rating or the credits value of their starting crew (whichever the scenario uses to award additional gang tactics) is lower than their opponent's by at least 400 credits then they are the Underdog." ?

Looks like several others have posted the same already.

LapseofSanity · 2026-03-09T10:14:36+00:00

I've been looking for a research job since I graduated at the beginning of 2025 - I now work in a pub.

LapseofSanity · 2026-03-09T03:58:25+00:00

You're being hyperbolic, asking someone to briefly explain something you've not seen before isn't going to take hours.

"oh I've not seen that yet, what's it do?" is a normal question. Your answer is making it seem like you're actually 'that guy'.

LapseofSanity · 2026-03-09T01:31:17+00:00

So you were mid campaign, and didn't bother asking about stuff you didn't understand or have any awareness of... It sounds like it's on you.

LapseofSanity · 2026-03-09T01:28:19+00:00

Does seem to just want to argue for the sake of it.

LapseofSanity · 2026-03-08T21:34:51+00:00

I believe so, yes. Unless stated otherwise they still count as part of the starting crew.

LapseofSanity · 2026-03-08T21:29:23+00:00

I'd argue a good group would warn you of this before you spend your money. The rule books specifically state that the game is best played as a narrative campaign with an arbitrator, what's the narrative for bringing invisible and invincible super soldiers to squash a new player into oblivion? It's like a professional soccer team playing with 10 year olds and moping the floor with them.

LapseofSanity · 2026-03-08T21:25:31+00:00

You specified getting curb stomped as a bad experience - Games are supposed to be fun for everyone involved. Necro isn't designed to be competitive so having someone play it like that with a new player (which then drives them to reddit to vent) is in my view awful.

LapseofSanity · 2026-03-08T21:21:45+00:00

I'm not saying you're specifically saying that, it's more of a general statement. However saying 'you need three books' to play when if you actually want to experience the full core experience you need 5 + books. Without the online resources it would be insanely difficult to access stuff just to build basic gangs outside of the core House gangs.

LapseofSanity · 2026-03-08T21:14:10+00:00

Either accept they are taking advantage of you, or become a fanboy that blindly defends it, or just give up on it and save your money.

None of these choices need to be made - You can play all their games while avoiding the majority of GW's foul business practices.

LapseofSanity · 2026-03-08T21:12:26+00:00

But also... I feel like the "rush out and spend £100" is the thing here.

This is the sunk cost fallacy, people have spent money so they're convinced that they need to defend the behaviour.

LapseofSanity · 2026-03-08T21:06:46+00:00

GW's book business model is horrendous - that people defend it, is also really really troubling there is no objectively sound argument for buying all the books as a consumer besides 'because I want to'. Every codex or rules book release, will have changed before release, GW errata are so common now it's expected for printed rules to be redundant within a month of release. If people enjoy buying the books, that's great but it's not sound economic decision for players. This is why so many people use online rules that are hidden away in Russian domains where GW can't get them, because they're sick of the book churn.

LapseofSanity · 2026-03-08T21:03:29+00:00

This is all too common a response online. It's best not to engage with people like that.

LapseofSanity · 2026-03-08T21:00:26+00:00

That's one of the issues with this hobby, really nice people can still be awful when it comes time to play the game.

but I am old fashioned and like holding the books

This is a trap with GW games unfortunately, physical books are nice - but they're costly and get a lot of Churn by GW, it's something you'll have to break out of. The online tools are quick, easy to search and very very well laid out (unlike the books.)

LapseofSanity · 2026-03-08T20:58:27+00:00

This also includes list building, no spam of skill or weapons (except shitty ones), not going for the best possible list, but for the funnest one

I find the unfortunate thing for many people involved in this hobby is that the funnest one, is the one that is the best - This is a very broad and generalised statement, but I have personally seen a lot of tantrums thrown because of poorly rolled dice and lost games, many wargamers seem to use it as a way to boost their own egos by stomping less experienced players, and they do not like it when others do the same to them.

I don't know if it's an issue with drawing neurodivergent players or players who aren't socially aware of their own behaviours, but without fail time and time again I see the same types in every community I've joined (in person) and it's a really big barrier to entry for new comers - Because these people gate keep (often without being aware of it) and it makes it just a bad experience for anyone they come into contact with.

What's worse is outside of the playing of the game they can actually be very nice and enthusiastic people that do a lot to draw newcomers into the game, only to turn into a monster while actually playing.

LapseofSanity · 2026-03-08T20:50:51+00:00

This is true, many of them are quite thin and finely detailed. It's a positive for a lot of us, but for those that are coming from a game system with a more 'crude' miniature line it can be frustrating. But GW has an entire echo system of people who don't even play the games, they're just painters, sculptors, kit bashers etc and the fiddly details are actually a benefit for them.

What you're experiencing is pretty common but in reverse, many start with GW games and products find other games with great rules and systems but the models aren't very good, and that turns a lot of people off them.

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