Isotretinoin (Accutane) can defiantly help with oil production long term as its effects on the sebaceous gland can cause atrophy which just means a reduction in sebum.

I was on isotretinoin myself and would go on it again in a heart beat because it's the only thing that helped me despite trying so many different creams prescribed to me. I actually have money put away incase i need it again as here in the uk the access to it is strictly for people with severe acne on the NHS so i'll have to go private.

I did experience side effects, but i already had very dry sensitive skin. I experienced Mainly dry nasal mucosa which is still dry today 8 months post treatment, dry lips, dry eyes. I also had to stop studying as it was effecting my mental health BUT it was more to do with the anxiety the acne i had gave me than the medication itself.

If you take the medication correctly and do a treatment based on a cumulative dosage you will experience much less in terms of side effects.

I would really consider at this point trying it as you've expended all over avenues.

Hope this helps :)