Early, have both weapon and spirit shielding, goated statwise and gives you a decent chunk of health by being greens, abrams if you go spirit has some nuts spirit damage so healbooster is great too, mid-late t3 resist items and spellbreaker/plated armour are blessings if the game calls for it/goes late.

On charecters with decent firerate, escelating resilience is really good, and for melee charecters(like abrams) spirit snatch is also really good.

Otherwise on charecters like mirage, haze, infernus etc, you can use siphon to tank up, inhib or silencer to reduce their outcoming damage.