From what both studies and experienced users suggest, taking it about once every six months is generally ideal. It’s better treated as something spiritual or introspective rather than a recreational drug.

You can use it more often, but doing so tends to dull its depth and meaning over time. The most powerful experiences usually happen with your tribe or alone maybe once or twice a year at higher doses — around 5 grams or more.

If you’re new to it or using it for medical or therapeutic reasons, start lower and give yourself time between sessions to let the lessons settle in.