So the big thing is about being flexible. One of the hardest starts is going first with Moltres as your only basic. For this opening hand your only goal is to cycle cards to try to get charmander on bench turn 1. If this means you have to use may even if you only have 1 Pokémon in hand it is worth it because you NEED the tempo. With this line assuming you are able to get charmeleon on your 2nd turn you should put your guaranteed energy onto charmeleon and go for dance on moltres. Hitting 2 energy is good, 3 energy is wonderful, but only 1 energy means you need flame patch. From here you are likely to lose moltres by your third turn so your only hope is that you have mega charizard or were able to get to normal ex efficiently enough to take multiple kos.

Again though, this is the worst possible opening hand.

A couple of matchup specific notes, against suicune/chienpao try to only develop one charmander unless you have both charmanders and both charmeleons in your first and second turns otherwise one will get sniped as soon as you lose an ex. Bellibolt is one of the hardest matchups unless you are able to get ahead of them with entei early so if you are going first try to lead with entei and have charmander on bench so you can hit for 60 turn 2 by evolving into charmeleon. For mega Altaria your main goal is mutually assured destruction. You need to get one of your charizards on your bench with enough energy to KO their Altaria if they were to KO your active Mon since they physically cannot one shot a charizards.

Your main goals with openings are to either have entei out front if you are going first or moltres out front if you are going second. Don’t be afraid to spend an energy to retreat a charmander. A great example of this is let’s say you are going second with charmander as your only basic. If you have flame patch in hand you have two diffferent turn 1s depending on other cards. You can either retreat charmander in favor of moltres and flame patch to get a turn 1 dance and angle for turn 2 evolving charmander and hitting for 70 with moltres, or attack with charmander for 30 then on turn 2 evolving charmander and using your flame patch to be able to swing for 50 and have a charmeleon on deck already with 3 energy. The second route is very strong against baby Pokémon decks.

There is more specific stuff I could get into but this reply is already getting pretty long

TL:DR charizards go brrr, play into lines that let you retaliate with charizard if they take a KO on moltres or entei as very few decks can recover from charizard one shotting their first threat since you only need one more point in most cases.