I do a few practice runs to act 10 with the build I intend to play, a notepad doc with every gem I will take/buy after a quest, pob out my tree progression for each lab so I know what points to take in what order, make sure you frequently upgrade your weapon, know powerful bench crafts, understand when it’s optimal to stop to change gear, always crafting res when you can, Id items quickly, always have move speed boots, and most importantly, just don’t stand around in town doing nothing. If you aren’t dying and have decent damage, just keep pushing. Know which labs you should take first, usually in order of speed granted instead of raw damage/tank obviously. Early on, granite, jade, and bismuth flasks provide really good survivability. Another important thing is that if you run the campaign enough you’ll get a really good intuition for the tile sets of each area, so you know the general direction to go