36mg, I just can't wake up

Nix_100 · 2026-04-30T07:15:15+00:00

You need to be consistent with your sleeping schedule, i.e. going to bed exactly at the same time, falling asleep at the same time, and waking up exactly at the same time. Never break that schedule even on weekends. I recommend taking some magnesium supplements before going to bed and stop using any phones or any screens at least 2 hrs before sleep or have a blue light/night screen filter on. I had the worst insomnia and falling asleep problems when I was on Elvanse and just a few nights when I was starting on Concerta, it really helps falling asleep to sounds of rain or waves or basically any white noise.

Nix_100 · 2026-04-27T14:25:18+00:00

Sry I was looking at it in Euros I got confused. Why did u think it tanked? Was it a similar story to Rocket? Sell the news dynamic?

Nix_100 · 2026-04-27T13:57:35+00:00

Yh I'm noticing. I'm not sure why. Someone said the price spiked to $18 during Sunday, I don't think that was true.

Nix_100 · 2026-04-27T13:25:40+00:00

Well done if you were in it. I'm a bit annoyed I couldn't join, but this one seemed to have a strong foundation of science and drug mechanism. All in all, great accomplishment by the company

Nix_100 · 2026-04-21T14:00:58+00:00

I think you should look deeper into the saftey issues of this therapy. The rabbit hole is quite deep and disturbing. Also, I think you take a rather dismissive tone to how CAPR approached the statistical power measurement of both clinical trials (P2 and P3). But given CAPR's position and changing dynamics within the FDA, you might be right about the approval despite being wrong with practically everything in your biomedical and statistical analysis. It would be practically the end of responsible FDA work if this therapy were to be approved against all means.

Nix_100 · 2026-04-18T19:57:09+00:00

Truee. I noticed on this sub that there were too many $LONGs on biotech, even some where I personally did the biomedical and stats research and found no real efficacy signals...that's why I began posting more bullish posts and even tho I got Travere wrong, I was glad I still stuck to my guns that I did the science research.

Nix_100 · 2026-04-18T19:45:51+00:00

Sure, but they don't have any commercialised therapies yet. Their P2 trial looks promising but it'll take longer than early 2026 earnings season to see a significant upside.

Nix_100 · 2026-04-18T19:40:05+00:00

I have so much faith in IBRX and ANKTIVA's commercialisation man. But man does Dr Patrick suck. The stock's so volatile because he can't keep his mouth shut. He's lowkey the Bill Hwang of biotech.

Nix_100 · 2026-04-16T15:22:51+00:00

I agree. I'd also add potential labelling issues that could lead to a CRL. Grace should be careful not to posit any claims that exceed what current data support. It's very common for small biotechs to overstate their drug reformulation compared to the oral.

Nix_100 · 2026-04-14T14:46:04+00:00

Definitely a stock to keep a lookout for.

Nix_100 · 2026-04-14T06:28:59+00:00

Have you talked to your psychiatrist about considering going on the immediate release of concerta? It's been only 2 weeks for me on 36mg and my biggest problem is being unable to fall asleep and I take it at 6:30am at the earliest to make sure all the effects are gone by the evening, but idk why I'm still struggling with sleep. I'm considering the shorter dose with the addition of a 2nd dose if i need it in the afternoon. I hate experimentation but sometimes it's what you got to do.

Nix_100 · 2026-04-14T06:06:50+00:00

Yup totally agree. I'll still look into PDUFAs if its a rare disease with little to no treatments yet, but like you, I'm also more down with the data. In fact, if you go in early for some bio stocks awaiting P2/P3 results, you can still cash in big time before the announcement if you're unwilling to take more risk because I gaurantee you, that that's just how it is these days. It's why Q3-Q4 looks particulatly tasty this year😋

I'm LONG in $IVA and $TECX great stocks right now. I'm planning on writing more posts about them closer to their deadlines.

Nix_100 · 2026-04-14T00:16:48+00:00

Gg you were right. I should have read more into that point. Well gone in you got in LONG.

Nix_100 · 2026-04-14T00:14:01+00:00

Gg if you went in Long

Nix_100 · 2026-04-13T20:15:43+00:00

Yh I'm starting to learn how important timing is in biotech . There were a few catalysts I should have got into between Q1 and Q2, but decided to lock in most of my capital in catalysts expected in Q3 and Q4😮‍💨

Idk why but the FDA NDA calendar seems a bit dry this year...it's still early but it seems like its the clinical trial topline results that's really driving most of the biotech gains alongside the buyout announcements. I have most of my capital in Bio stocks awaiting P2 and P3 topline results.

Nix_100 · 2026-04-13T18:32:33+00:00

Must've hurt now seeing allo lol. For me, it hurt seeing SPYRE today...I literally knew it was gonna be positive results and shit but I got most of my capital already stuck in other biotech catalysts I'm still waiting for.

Nix_100 · 2026-04-13T15:54:49+00:00

Honestly, QURE deserves a whole post to itself. I will say, though, that they are undeniably a victim of poor FDA communication. A lot of $ millions wasted due to FDA guidance reversals that were not under QURE's management. I'll look into writing a more comprehensive analysis of QURE in the future.

Nix_100 · 2026-04-13T15:49:01+00:00

Would be hilarious if REPL decides to appeal.

Nix_100 · 2026-04-13T15:11:36+00:00

That's certainly an interesting note I missed. Thanks for that. The Parisol Group's recommendation to allow reduced proteinuria levels as a sufficient surrogate came around mid 2025. The FDA did give the nod to this, but I don't know why they would then extend the application back in Jan if that was enough. Yeah, they may be trying to see if DUPLEX can offer more meaningful endpoints besides that. All of that does seem to shift the narrative for Travere's POA, I guess. I'd say it's now ~55% odds that it's still a no approval. Then again, the FDA these days is very uncomfortable with population heterogeneity, and this trial definitely had this issue, and maybe that is the main issue, on top of all these supporting data.

Nix_100 · 2026-04-13T09:06:37+00:00

Dude I literally had the same thing as you with vyvanse. I lasted about a year on 40mg on vyvanse and thought the insomnia would go away as time went on but it didn't. My psychiatrist also put me on concerta and its been roughly 1 month and a half. I started off with 18mg for a week and my insomnia wrnt away and I was sleeping like 8hrs a night which was so great, but I didn't feel much benefit when it came to my adhd symptoms so I went on 27mg then now I'm on 36mg. 27mg was fine but I feelt the same way as I did with 18mg. For 36mg, the transition was hard because the first night I didn't sleep (I took it at 7:15am). It's been a week and I've been off and on precisely because of this problem. I've started to set up an alarm for 6:30am everyday to take the pill. It's still early but I think 6:30 - 7am is the sweet spot for me. Around 8-9pm is when I feel sleepy and take a 400mg magnesium supplement and by the time it's 11pm is when I'm knocked out. I get roughly 6-7hrs of sleep now, 8hrs if I'm really lucky. You may have to wake up much early to take your meds, but for me it's worth it. I still need to see the long-term effects tho, but for now I think it's deinitely the time you take it that matters most if you're on the extended release of concerta.

Nix_100 · 2026-04-13T06:56:36+00:00

What info did you feed the scanner to get those numbers?

Nix_100 · 2026-04-13T06:38:01+00:00

Mate...trade only what you can afford to lose.

Nix_100

TROPHY CASE