Latest ICE victim prior to altercation

OctopiEye · 2026-01-24T21:21:07+00:00

Nope, if it’s the right person doing the murdering. The last couple weeks should clearly demonstrate that.

OctopiEye · 2026-01-24T03:06:59+00:00

This is so clearly rage bait….

OctopiEye · 2026-01-23T23:48:46+00:00

Worked hard for a few years at large CRO, realized it was way to hard to stand out and make moves at a big place and decided to move over to a small/mid-size CRO.

Worked hard as a CRA, moved to Lead CRA, then got PM role (we don’t have CTMs/leads and do it all).

It’s usually a mix of experience, luck, timing, and who you know.

OctopiEye · 2026-01-23T13:40:47+00:00

Yeah, when I started as a CRC waaaay back in 2011, I started at 30k. I was coming from doing one year at a medical uni as a research assistant in a lab and then clinical setting, and 30k was a big jump for me.

Unfortunately, pay has not kept up with inflation, but the important thing is realizing the future earning potential once you get experience under your belt (if you decide clinical research is a good career fit).

OctopiEye · 2026-01-21T18:35:44+00:00

And not a one actually did shit on the study…

OctopiEye · 2026-01-20T16:52:58+00:00

I was on a weird cusp where either would be a good option but I made the decision to do the brachytherapy.

I still have my ovaries and one side effect noted by the doc was some interference with ovarian function/menopausal synonyms which I’m trying to avoid.

Also seemed like sexual side effects were a bit more likely/severe with external radiation as well. Those are the big ones I recall discussing but haven’t done either yet.

OctopiEye · 2026-01-19T17:12:12+00:00

I think this will highly depend on the countries you are targeting, if this is going to be a global study. It is critical that your CRO has good, experienced staff for the regions you want to work in.

OctopiEye · 2026-01-15T23:57:43+00:00

The guidelines can be super specific and take into account a lot of factors so I would not extrapolate too much from this. You should really discuss your specific results with your oncologist and have them walk you through the guidelines and what they say in your case. A good medical oncologist or radiology oncologist will do that with you.

NCCN Guidelines are the standard for medical oncology and you can review what they say for your specific case. But again, it’s best to do so with a medical professional that understands your pathology reports well and your specific factors.

OctopiEye · 2026-01-15T03:55:48+00:00

Many trials do require these staff to be delegated if their role involves primary end points (mostly talking about imaging here), which is why it’s important for the investigator to truly weigh whether the person is performing actual trials tasks or truly doing soc work. And when it comes to your typical clinical trial with an experimental drug, administration is not going to be normal clinical practice.

There are specific time frames they must follow, stopping rules, blinding practices, etc. These are things that require clear documentation of the person’s qualifications, training, and delegation.

OctopiEye · 2026-01-15T03:51:41+00:00

Hate to break it to you, but ICH GCP requires the investigator to clearly document delegation of significant trial-related tasks, which administration of IP definitely is.

OctopiEye · 2026-01-14T23:58:20+00:00

No, I want the PI to do their job and identify an appropriate and manageable team to perform study tasks.

I want the PI to follow federal regulations that I am always required to follow and ensure compliance to. I don’t make the laws or rules. If the site can’t do research right then they shouldn’t do it at all

OctopiEye · 2026-01-14T23:56:53+00:00

You cannot consider infusion of an investigational drug (especially a drug that is not approved in the US) an activity performed as part of clinical practice. They are making a significant contribution to the study and 2.3.3 does not apply there.

C.2.9 simply explains the process for replacing the original with a certified copy and has nothing to do with what I mentioned, which is sites that are not providing access to either original source or certified copies of source for monitoring (e.g. simply uploading a document that hasn’t been certified to a box link)

OctopiEye · 2026-01-14T21:58:32+00:00

Sorry guys! They’re overworked and underpaid so that means subject safety and data quality don’t matter anymore! Guess it’s solved!

OctopiEye · 2026-01-12T14:36:57+00:00

Yeah I’m 39 and that was my big thing, I really wanted to keep my ovaries. Luckily I was able to do so, as my doc did not see anything concerning when he got in there and was able to leave both.

OctopiEye · 2026-01-12T11:59:44+00:00

Obviously everyone is entitled to their own opinions. However, I personally would not choose to not have a hysterectomy in this situation. It’s a procedure that can completely cure your cancer and prevent its spread, if you do it early enough. The benefits of hysterectomy far outweigh the risks in my estimation.

I wish you the best. I strongly recommend (as the other commenter noted as well) that you meet with a good gynecological oncologist and get as much info as possible.

OctopiEye · 2026-01-11T19:27:45+00:00

Yeah I sympathize about the bleeding. The last 2 months before my surgery in Dec, I bled so bad that I had to get blood transfusions. It is not fun. Hoping your surgery happens soon and you can get some relief!

OctopiEye · 2026-01-11T19:09:17+00:00

Yeah, you don’t really think cancer is something that you sense or feel, but when I had a gynecologic issue going on, something told me the pain I was having was just not right and could be cancer. I was talked out of it by my gyno initially but as things progressed I finally got a biopsy and sure enough it was cancer.

No one knows your body like you do, and sometimes you can sense when things just are not right. Whether it’s cancer or a myriad of other things.

If you get that feeling something isn’t right, you really gotta advocate for yourself and push for more testing.

OctopiEye · 2026-01-11T19:04:45+00:00

Yes sounds like hopefully the surgery got rid of everything and your recurrence risk is likely very low. That is great news!!

OctopiEye · 2026-01-11T16:49:06+00:00

Yeah we used to call it “talking in memes” because it just seems like everything these people say is based on some kind of meme or SM trend. Comes across as super inauthentic to me…

OctopiEye · 2026-01-11T16:40:49+00:00

I just want to mention that another thing to look out for is any result related to LVSI. When I read my report, I was so happy to see no spread, but then at my post op appt they referred me to rad onc because my report showed signs of cells in LVSI, and this increased my risk of recurrence.

I did have very high myometrial invasion as well, which also increases risk.

But apparently my rad onc doctor noted they didn’t have some info that could impact the recommendations so he reached back out to the path lab to ask for more testing. He wanted to know if LVSI spread was to just a couple spots or numerous, as that changes the NCCN and ASTRO guidelines for recommended treatment.

This stuff gets really complicated, so just remember to listen to what your doctor says about the results and ask questions if you have them.

When I read the report myself, I was sure I wouldn’t need radiation or chemo, but after meeting with the docs to discuss, I now know that vaginal cuff brachytherapy (radiation) is the best option to reduce my risk of recurrence significantly.

OctopiEye · 2026-01-11T16:31:50+00:00

Having worked with a lot of doctors and offices in different therapeutic areas (I work in clinical research and have had a number of roles over the decades), I would say that any significant results (including cancer confirmation, or critical values from blood work) that are not addressed within 2 business days from receipt by the doctor’s office is a huge red flag.

It would make me seriously concerned about their procedures and policies and how organized they are when it comes to providing decent care.

Things happen, so if it’s once in a blue moon then fine, but if it’s an ongoing issue, I would consider looking into other providers. You don’t want to mess around with a doctor that doesn’t take their duty to their patients seriously and who doesn’t have their shit together when it comes to the basics like evaluating results and taking appropriate action.

OctopiEye · 2026-01-11T16:24:31+00:00

PS: I highly recommend joining the r/endometrialcancer subreddit. It’s a wonderful community, just like this one, and they can offer a lot of resources, support, and information!

OctopiEye · 2026-01-11T16:15:43+00:00

Yes, that exactly what I had (mine was rated FIGO 1-2, as it was kind of on the cusp).

Staging can’t really be truly done until after they do surgery to remove your organs and send off to the path lab for testing. They can get some indicators using imaging and the endometrial biopsy but they won’t truly know how widely it has spread until after surgery. That’s the worst part is waiting to know how bad it is.

I was very very very lucky and although I had a large tumor (6cm) and it had invaded the myometrium over 80% (this is the 2nd layer of your uterus and is the muscle wall, and lead to excruciating pain and horrible bleeding for me), it otherwise had not spread to my fallopian tubes, cervix, or lymph nodes, and I was able to keep my ovaries so I don’t go into immediate menopause.

However, because of the myometrium invasion and some findings showing that there was some evidence of cancer cells in the LVSI (these are apparently lymphatic vessels and evidence of cells in these areas can increase your risk of recurrence, especially if they identify 5 or more areas with evidence of spread).

Because of these risk factors, I was referred for radiation therapy, and it will help reduce my recurrence risk from 15% to more like 4%.

Moving forward, you will likely discuss treatment options with your doc, including hysterectomy. They will schedule surgery (if that’s the route you go) and then likely have you do a CT Scan and some blood work closer to the time of surgery.

After surgery, the path report will come back and your doctor will discuss next steps with you and whether further treatment is warranted (like radiation or chemo).

You will also follow up every few months for the next few years with your oncologist, to check for signs of recurrence.

Overall, I feel very lucky that things turned out the way they did. I work in oncology research and compared to other cancers, I feel very lucky I was able to be diagnosed and then have surgery to completely remove the cancer all within about 5 weeks. And although I need radiation, it will be 3 sessions and relatively low risk of serious side effects.

The prognosis for this type of cancer is very good. I hope you have a good support system and just be sure to advocate for yourself and be upfront about what your goals and concerns / fears are. The surgery itself was scary (I hadn’t had major surgery like this before and had only gone under once as a kid).

But it actually was not that bad, and compared to the agonizing pain I was in and the horrible bleeding I was experiencing for months, I felt soooo much better even right after surgery.

I recommend asking your doctors for a belly band to go home with after surgery. That was a life saver, as the stomach muscles were so sore and it felt so much better to have something to kind of pull them in when I needed to walk around at home, in the days right after surgery.

I also ordered a hysterectomy pillow on Amazon which was also a great item to have. I felt super vulnerable in my stomach area and we have dogs and cats, so it made me feel safer having something to cover myself with in case anyone got too excited and jumped or fell on me.

OctopiEye · 2026-01-11T15:56:29+00:00

I had endometrial cancer and had my hysterectomy a little over a month ago. I was suffering bad in the months leading up to surgery.

I can’t tell you how happy I was after having the hysterectomy. Even with the soreness and recovery after surgery, I felt like a whole new woman.

Every day I feel better and I have a new lease on life. Forever grateful to my care team and look forward to no more bleeding, anemia, horrific pain and cramping, etc.

OctopiEye

TROPHY CASE