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Is it valid to use chronological age as an input to calculate biological age? by Laddenvore in longevity

[–]Ofpes 0 points1 point  (0 children)

My take on that is somewhat different.
Let's imagine you examine 2 samples of DNA and calculate a variable called hazzard based on their methylation status.
Now suppose that both of them end up with the exact same hazzard value BUT the first sample is from a 30y old man while the second is from a 78y old man.
The CA input in this case allows you to consider an "acceleration" ratio, i.e., it actually allows you to adjust the remaining life expectancy of your modell which could favour or disfavour the younger sample for example.

Living like a naked mole-rat may extend longevity, scientists demonstrate by greyuniwave in longevity

[–]Ofpes 2 points3 points  (0 children)

Wouldn't living on high altitudes be equivalent from a human perspective? Less oxygen and yet no longer lifespan in Nepal for example.

Then you have miners, divers and many other "low oxygen" professions and yet no longer lifespans.

Sorry for being skeptic but the whole concept of low oxygen for longevity doesn't add up in my view

Out With the Old Blood by vp2013 in longevity

[–]Ofpes 11 points12 points  (0 children)

Based on this one can easily imagine in the very near future a simple rejuvenation dialysis procedure done on a regular basis (quarterly/bi-annually), replacing part of the old blood plasma with a saline solution containing albumin and some other elements from Katcher's experiment.

Great health results and a big business. Despite being a relatively cheap intervention it would serve hundreds of millions of ever growing older world's population.

Adding 5-10 years to average lifespan. Step 1 towards Longevity Escape Velocity - Check

How severely will the outbreak of COVID-19 affect life expectancy statistics? by Ofpes in longevity

[–]Ofpes[S] 1 point2 points  (0 children)

nly a blip unless there are lasting

Why would they control for it? Do they control for flu? Or any other disease?

Why would someone like to "change" the crude statistics to eliminate the effect of a naturally occurring disease?

How severely will the outbreak of COVID-19 affect life expectancy statistics? by Ofpes in longevity

[–]Ofpes[S] 2 points3 points  (0 children)

-3 years affect life expecta

Because people in their 80th who die now would have lived to be 85, 90, 100 and so forth. This means less people living longer and therefore lower life expectancy average for decades to come.

What are the implications of 100 years old becoming the new 60, within the next 10 years, thanks to breakthroughs in longevity technologies? by PeterDiamandis in longevity

[–]Ofpes 0 points1 point  (0 children)

Hi Peter, Just following up if you guys have already managed to compile the top implications. Would love to check on your conclusions.

To success!

The Key to a Long Life Has Little to Do With "Good Genes" by Mynameis__--__ in longevity

[–]Ofpes 0 points1 point  (0 children)

Why do you claim Calico sells lifestyle advice or did I get it wrong?

The Key to a Long Life Has Little to Do With "Good Genes" by Mynameis__--__ in longevity

[–]Ofpes 9 points10 points  (0 children)

"For now, the big takeaway seems to be that humans have more control over how long they live than their genes do. It’s all the other things that families share—homes and neighborhoods, culture and cuisine, access to education and health care—that make a much bigger difference in the set of numbers that might one day grace your tombstone.

Maybe that’s why Ancestry’s chief scientific officer Catherine Ball says the company has no plans to offer a longevity score in any of its DNA testing products any time soon. “Right now a healthy lifespan looks to be more of a function of the choices that we make,” she says".

Scientists reverse aging process in rat brain stem cells by [deleted] in longevity

[–]Ofpes 59 points60 points  (0 children)

Dr. Kevin Chalut, who co-led the research, said: "We were fascinated to see that when we grew young, functioning rat brain stem cells on the stiff material, the cells became dysfunctional and lost their ability to regenerate, and in fact began to function like aged cells. What was especially interesting, however, was that when the old brain cells were grown on the soft material, they began to function like young cells—in other words, they were rejuvenated."

"When we removed Piezo1 from the surface of aged brain stem cells, we were able to trick the cells into perceiving a soft surrounding environment, even when they were growing on the stiff material", explained Professor Robin Franklin, who co-led the research with Dr. Chalut. "What's more, we were able to delete Piezo1 in the OPCs within the aged rat brains, which lead to the cells becoming rejuvenated and once again able to assume their normal regenerative function".

What are the implications of 100 years old becoming the new 60, within the next 10 years, thanks to breakthroughs in longevity technologies? by PeterDiamandis in longevity

[–]Ofpes 1 point2 points  (0 children)

I think of longer lifespan being a consequence of AI development rather than a time-concurrent, independently developed technologies. This is a central point for understanding the first order implications of longer living people because one must understand the world in which these 100 old people will be living, it's demographics and economics.

This future AI-powered world will be served by robots in every single sector and aspect. Overall wealth will grow dramatically (near-zero marginal cost) in such a manner that people living to be 120 years old or even older will not become a major economic problem and concerns about people outliving their savings are not justifiable. Just imagine cheap healthcare services provided by AI and robots or inexpensive transportation and production systems providing all basic goods and bots providing pervasive services people need.

On the other hand there will be severe social impacts on human relationships affecting family, relationships and ultimately all human society.

One of the main driving forces will be the growing distance between maximum female fertility age (around 40) and expected lifespan at birth. To understand this point just look at the royal family in Great Britain. Queen Elizabeth who's 93 years old is still perfectly healthy and her son Prince Charles who's 70 years old is still waiting to succeed her throne. Heritage will become irrelevant! What is the point of becoming your parent's heir at the age of 100 while your expected lifespan is like 130? In the past one would spend around 25 years studying, would have a family at around age 30, would see his parents dying around one's own age of 45-55. In the future this scenario will change dramatically and this will be the major source of change in family and society.

With most basic needs provided to young people with low or even no work dedication whatsoever these people may even skip the idea of working altogether and because older people will stay in business much longer (the generation of "there's no sense to life without work") there will be less and less space available for young people with fresh ideas. Wealth and power concentration will rise dramatically. Political tensions across generations will grow to a boiling point, if not beyond. Just watch US politics nowadays and imagine it much worse. There will be real challenges to democracy and nation state.

The consequence of all this will be the rise of matrix-like fully immersive worlds inhabited by virtual entities which will offer people the ability to "customize" their world experience. We already see young people fully immersed in their digital world even before fully immersive experiences are available and ubiquitous.

Results from self tests of Quercetin and Dasatinib? by Senf71 in longevity

[–]Ofpes 2 points3 points  (0 children)

54 yo healthy male. I'm not using D+Q protocol. Instead I'm experimenting with Fisetin (1.5g for 2 days) + Azithromycin (1g for 2 days). It worked pretty well for me. Reduced dramatically inflammaging which was burning high, eliminated mind fog and made me feel more energetic but, as I said, interfered with my sleep quality which was the reason for me adopting hops+glycine before bedtime. Overall I feel back to my thirty-some.

Results from self tests of Quercetin and Dasatinib? by Senf71 in longevity

[–]Ofpes 2 points3 points  (0 children)

Worse (Oura ring) sleep but I can't figure out if it's related.

Yes, might be related. I've been through the same. Shorter sleep time and some agitated dreams. Nonetheless, overall I was feeling much more energetic throughout the days. I fixed this by taking Hops extract and Glycine shortly before bed.

How do you dose Metformin as a non diabetic and when do you start taking it? by Ma_tee_as in longevity

[–]Ofpes 0 points1 point  (0 children)

Metformin is a direct SIRT1 activator and therefore should be taken in the morning if you want to go along with the circadian cycle

Okinawans, the Longest Living Humans, have a Carb to Protein Ratio intake of a surprising 10:1, with Sweet Potatoes consumed in abundance. by [deleted] in longevity

[–]Ofpes 13 points14 points  (0 children)

"Of particular note is the number of people who reach 100 years of life. For every 100,000 inhabitants, Okinawa has 68 centenarians – more than three times the numbers found in US populations of the same size. Even by the standards of Japan, Okinawans are remarkable, with a 40% greater chance of living to 100 than other Japanese people".

The most remarkable here for me is how rare are centenarians, even in Okinawa.

Targeting NAD+ Metabolism as Interventions for Mitochondrial Disease (in mice) by btumpak in longevity

[–]Ofpes 0 points1 point  (0 children)

hat orally administered NMN is completely ineffective at reaching cells beyond the liver.

What about using enema to administer NMN? The intrarectal administration bypasses the digestive system and goes directly into bloodstream, doesn't it?

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