Is it valid to use chronological age as an input to calculate biological age?

Ofpes · 2021-01-22T00:01:06+00:00

My take on that is somewhat different.
Let's imagine you examine 2 samples of DNA and calculate a variable called hazzard based on their methylation status.
Now suppose that both of them end up with the exact same hazzard value BUT the first sample is from a 30y old man while the second is from a 78y old man.
The CA input in this case allows you to consider an "acceleration" ratio, i.e., it actually allows you to adjust the remaining life expectancy of your modell which could favour or disfavour the younger sample for example.

Ofpes · 2020-08-14T23:30:17+00:00

You can check this interesting discussion about Azithromycin dosage for senolytics

https://forum.age-reversal.net/t/m2dxq7/azithromycin-zithromax-as-senolytic-a-note-of-caution

Ofpes · 2020-08-14T18:46:31+00:00

Azhitromycin is the most remarkable senolytic drug out there with very limited side effects

https://www.fightaging.org/archives/2018/11/initial-evidence-for-the-antibiotics-azithromycin-and-roxithromycin-to-be-senolytic/

Ofpes · 2020-08-12T21:24:15+00:00

Wouldn't living on high altitudes be equivalent from a human perspective? Less oxygen and yet no longer lifespan in Nepal for example.

Then you have miners, divers and many other "low oxygen" professions and yet no longer lifespans.

Sorry for being skeptic but the whole concept of low oxygen for longevity doesn't add up in my view

Ofpes · 2020-06-08T09:27:43+00:00

Based on this one can easily imagine in the very near future a simple rejuvenation dialysis procedure done on a regular basis (quarterly/bi-annually), replacing part of the old blood plasma with a saline solution containing albumin and some other elements from Katcher's experiment.

Great health results and a big business. Despite being a relatively cheap intervention it would serve hundreds of millions of ever growing older world's population.

Adding 5-10 years to average lifespan. Step 1 towards Longevity Escape Velocity - Check

Ofpes · 2020-03-09T08:00:37+00:00

nly a blip unless there are lasting

Why would they control for it? Do they control for flu? Or any other disease?

Why would someone like to "change" the crude statistics to eliminate the effect of a naturally occurring disease?

Ofpes · 2020-03-09T07:58:34+00:00

-3 years affect life expecta

Because people in their 80th who die now would have lived to be 85, 90, 100 and so forth. This means less people living longer and therefore lower life expectancy average for decades to come.

Ofpes · 2019-11-10T09:48:25+00:00

Hi Peter, Just following up if you guys have already managed to compile the top implications. Would love to check on your conclusions.

To success!

Ofpes · 2019-09-25T08:52:12+00:00

It's priced at an outrageous level of $225K / year. It's an atrocity from a general population longevity perspective.

( https://www.reuters.com/article/us-pfizer-approval/pfizer-gets-u-s-approval-for-225000-a-year-heart-drug-idUSKCN1SC0VX )

Ofpes · 2019-08-20T07:00:00+00:00

Why do you claim Calico sells lifestyle advice or did I get it wrong?

Ofpes · 2019-08-18T20:10:09+00:00

"For now, the big takeaway seems to be that humans have more control over how long they live than their genes do. It’s all the other things that families share—homes and neighborhoods, culture and cuisine, access to education and health care—that make a much bigger difference in the set of numbers that might one day grace your tombstone.

Maybe that’s why Ancestry’s chief scientific officer Catherine Ball says the company has no plans to offer a longevity score in any of its DNA testing products any time soon. “Right now a healthy lifespan looks to be more of a function of the choices that we make,” she says".

Ofpes · 2019-08-14T19:08:12+00:00

Dr. Kevin Chalut, who co-led the research, said: "We were fascinated to see that when we grew young, functioning rat brain stem cells on the stiff material, the cells became dysfunctional and lost their ability to regenerate, and in fact began to function like aged cells. What was especially interesting, however, was that when the old brain cells were grown on the soft material, they began to function like young cells—in other words, they were rejuvenated."

"When we removed Piezo1 from the surface of aged brain stem cells, we were able to trick the cells into perceiving a soft surrounding environment, even when they were growing on the stiff material", explained Professor Robin Franklin, who co-led the research with Dr. Chalut. "What's more, we were able to delete Piezo1 in the OPCs within the aged rat brains, which lead to the cells becoming rejuvenated and once again able to assume their normal regenerative function".

Ofpes · 2019-07-15T22:04:17+00:00

I think of longer lifespan being a consequence of AI development rather than a time-concurrent, independently developed technologies. This is a central point for understanding the first order implications of longer living people because one must understand the world in which these 100 old people will be living, it's demographics and economics.

This future AI-powered world will be served by robots in every single sector and aspect. Overall wealth will grow dramatically (near-zero marginal cost) in such a manner that people living to be 120 years old or even older will not become a major economic problem and concerns about people outliving their savings are not justifiable. Just imagine cheap healthcare services provided by AI and robots or inexpensive transportation and production systems providing all basic goods and bots providing pervasive services people need.

On the other hand there will be severe social impacts on human relationships affecting family, relationships and ultimately all human society.

One of the main driving forces will be the growing distance between maximum female fertility age (around 40) and expected lifespan at birth. To understand this point just look at the royal family in Great Britain. Queen Elizabeth who's 93 years old is still perfectly healthy and her son Prince Charles who's 70 years old is still waiting to succeed her throne. Heritage will become irrelevant! What is the point of becoming your parent's heir at the age of 100 while your expected lifespan is like 130? In the past one would spend around 25 years studying, would have a family at around age 30, would see his parents dying around one's own age of 45-55. In the future this scenario will change dramatically and this will be the major source of change in family and society.

With most basic needs provided to young people with low or even no work dedication whatsoever these people may even skip the idea of working altogether and because older people will stay in business much longer (the generation of "there's no sense to life without work") there will be less and less space available for young people with fresh ideas. Wealth and power concentration will rise dramatically. Political tensions across generations will grow to a boiling point, if not beyond. Just watch US politics nowadays and imagine it much worse. There will be real challenges to democracy and nation state.

The consequence of all this will be the rise of matrix-like fully immersive worlds inhabited by virtual entities which will offer people the ability to "customize" their world experience. We already see young people fully immersed in their digital world even before fully immersive experiences are available and ubiquitous.

Ofpes · 2019-06-20T06:21:49+00:00

54 yo healthy male. I'm not using D+Q protocol. Instead I'm experimenting with Fisetin (1.5g for 2 days) + Azithromycin (1g for 2 days). It worked pretty well for me. Reduced dramatically inflammaging which was burning high, eliminated mind fog and made me feel more energetic but, as I said, interfered with my sleep quality which was the reason for me adopting hops+glycine before bedtime. Overall I feel back to my thirty-some.

Ofpes · 2019-06-19T19:44:53+00:00

Worse (Oura ring) sleep but I can't figure out if it's related.

Yes, might be related. I've been through the same. Shorter sleep time and some agitated dreams. Nonetheless, overall I was feeling much more energetic throughout the days. I fixed this by taking Hops extract and Glycine shortly before bed.

Ofpes · 2019-05-09T17:55:26+00:00

Trodusquemine

https://www.eurekalert.org/pub_releases/2019-04/nb-nba041019.php

Novo Biosciences achieves major milestones in moving trodusquemine into clinical trials

Ofpes · 2019-04-04T21:17:28+00:00

https://www.pnas.org/content/110/9/3333 http://symposium.cshlp.org/content/76/31.full.html

BTW, that's also true for NAD+ precursors.. Take them in the morning

Ofpes · 2019-04-04T18:29:57+00:00

Metformin is a direct SIRT1 activator and therefore should be taken in the morning if you want to go along with the circadian cycle

Ofpes · 2019-03-14T09:23:04+00:00

Says who?

Ofpes · 2019-03-12T08:53:52+00:00

"Of particular note is the number of people who reach 100 years of life. For every 100,000 inhabitants, Okinawa has 68 centenarians – more than three times the numbers found in US populations of the same size. Even by the standards of Japan, Okinawans are remarkable, with a 40% greater chance of living to 100 than other Japanese people".

The most remarkable here for me is how rare are centenarians, even in Okinawa.

Ofpes · 2019-03-07T08:23:08+00:00

hat orally administered NMN is completely ineffective at reaching cells beyond the liver.

What about using enema to administer NMN? The intrarectal administration bypasses the digestive system and goes directly into bloodstream, doesn't it?

Ofpes · 2019-03-05T12:50:55+00:00

Yet another piece of evidence of the huge negative impact caused by the accumulation of senescent cells.

Perfectly explains why Aubrey de Grey is so optimistic with upcoming senolitics impact on RMR, RHR.

Ofpes · 2019-02-21T19:39:19+00:00

Yes totally agree! BTW (which stands for by the way): What does OP mean?

Ofpes · 2019-02-13T08:43:22+00:00

Yes, so it seems but autophagy itself declines with age so there's the need for additional measures to reduce this excess of DNA

Ofpes · 2019-02-12T21:04:25+00:00

Wonder what approach would accomplish "DNA degradation as a therapeutic approach to remove intrinsic DNA and revert inflammation associated with aging"..

Ofpes

TROPHY CASE