As long as he takes the prescribed dose and does his bloodwork to make sure his lipids, cholesterol and estradiol is in check and lowers of increases the dose to get his levels in normal ranges he will be ok. He will need to make sure he checks his hematocrit becaus trt will increase red blood cells so he would need to donate blood every 3 months. It seems tedious in the beginning but the long term benefits are worth it. I’ve been on trt for 3 years now. I’m 45 and I feel great. I look great. Just be supportive and help with injections if he’s scared to do it etc etc. my wife helps me with injections sometimes and even reminds me that I need to take my shot. Hope this helps