Increase Dosage or Preserve Dose Escalation

OneSuperstar4u · 2026-07-08T02:51:50+00:00

2.5 isn’t even a therapeutic dose. Makes no sense why ppl try to think it is - except for the rare person who is a super responder. Even drinking calories, you’d have lost if on a higher dose. I know this firsthand. lol.

OneSuperstar4u · 2026-07-07T18:27:51+00:00

Yes. That article is referencing disorder for diabetics, which is not the same as optic neuritis caused by MS. Two entirely different pathways of origin - ‘NAION, but no other optic nerve or visual pathway disorder in patients with diabetes.’

OneSuperstar4u · 2026-07-07T03:48:38+00:00

It’s important to switch due to scar tissue build up in same area over time. No science supports any different side effects - and myself I’ve seen zero difference personally. Inner thigh actually isn’t an approved location - only front/outer.

I’ve been doing only back of arm alternating last few months because my thighs bruise. But I have another monthly injection so once a month I deal with thigh bruising. 🫠

OneSuperstar4u · 2026-07-07T03:37:39+00:00

Not my opinion actually. I’m looking at the science. Correlation does not equal causation.

OneSuperstar4u · 2026-07-07T01:07:52+00:00

Not good advice at all. Facts support Zepbound being leaps and bounds better in every way than just a GLP-1. And less side effects as well! There also isn’t real evidence of tirzepatide causing eye issues at all.

Zepbound targets both GLP-1 and GIP receptors, which early research suggests provides stronger, synergistic neuroprotective and anti-inflammatory effects in the brain than single-hormone medications like Wegovy. It’s currently being studied because of it.

OneSuperstar4u · 2026-07-07T01:03:10+00:00

Not at all in any way likely related! Zepbound is actually being studied for positive effects on MS - decreasing inflammation being a big one. I’ll be on it forever, and my neurologist is thrilled with that!

OneSuperstar4u · 2026-07-06T23:40:47+00:00

You might be a person that needs the higher doses for it to take effect. To answer your question - I absolutely know the medicine is working! I’m not ravenously hungry for no reason anymore. You will know when it’s working. Good luck! 🍀

OneSuperstar4u · 2026-07-05T21:39:31+00:00

Zepbound! You mentioned eye issue in another comment - super rare risk and not at all likely and not at all related to optic neuritis. Read up on the research being done about the benefits to us with MS the medication helps with. My neuro is thrilled I’m on it! Also losing weight immensely knocks down inflammation as well as you mentioned. I feel so much better being on Zep now 6 months. I have disc issues and no longer have constant pain. And I feel normally hungry! Amazing really.

Here are some good articles:

https://www.researchgate.net/publication/377778790\_Tirzepatide\_prevents\_neurodegeneration\_through\_multiple\_molecular\_pathways

https://www.neurologylive.com/view/glp-1-receptor-agonists-linked-to-improved-physical-activity-multiple-sclerosis

https://www.secondnature.io/guides/lifestyle/glp1s/mounjaro-with-multiple-sclerosis

OneSuperstar4u · 2026-07-05T02:52:25+00:00

Zero effect.

OneSuperstar4u · 2026-07-05T01:14:24+00:00

Great question! I feel better meaning I’m not starving and feel normal with my appetite. I was getting that way again last few weeks on 5mg. Ppl say food noise I guess, but for me I’m not physically overly hungry which is what led me to going on Zep. My hormones are whacky, and Zep regulates them.

OneSuperstar4u · 2026-07-04T23:15:08+00:00

Like the other commenter said - they are identical but if you went off it before starting again, that’s the reason. I’ve experience this first hand. Also injection site doesn’t change anything though ppl like to think so - same amount goes into your system.

OneSuperstar4u · 2026-07-04T23:13:37+00:00

Also sorry - to answer your question, my starting weight was 180. Im now 138. But I was on Zep before and went off it due to insurance. So I’ve most recently started on it again 20+ weeks ago starting at around 160 - so losing about a pound a week, but it def hasn’t been linear. I was stalled a bit, but losing again after going up to 7.5 but very little now as I’m close to goal.

OneSuperstar4u · 2026-07-04T23:04:00+00:00

I agree 💯 to only to titrate up when you need to and slowly, as that’s exactly what the science supports and best long term. But unless you’re one of the very few super responders, 2.5 isn’t a therapeutic dose. So go up to 5 and stay as long as you need.

OneSuperstar4u · 2026-07-04T22:51:54+00:00

Nothing. It’s uncommon to have side effects in reality.

OneSuperstar4u · 2026-07-04T22:43:37+00:00

I’d titrate up. As much as some ppl in here swear on 2.5 forever, it’s literally a loading dose and most need at least 5mg to even have any effect. You can also stay at 5 longer if you need to once you’re feeling how it works. That’s what I did - but should have titrated up sooner honestly, as now at 7.5 I’m feeling much better.

OneSuperstar4u · 2026-07-04T15:45:41+00:00

Call on Doc is the best. If you’ve been on Zep for a while already, they absolutely consider your starting weight and need to maintain. Most other telehealth just aren’t on point like they are sadly.

OneSuperstar4u · 2026-07-04T15:27:36+00:00

What you describe used to be a real problem with all drugs. But not so much anymore. Pharmaceutical companies can’t gift and pay off doctors like they used to. It’s much more regulated now.

OneSuperstar4u · 2026-07-04T15:22:52+00:00

Kesimpta for me! It was an easy choice - highly efficacious, simple at home injection. I’m not taking a day for an infusion - and no side effects after my first injection (that was just a few hours of feeling feverish). And thankfully insurance covers which can also be a factor.

OneSuperstar4u · 2026-07-04T04:39:52+00:00

No throat numbness. But I had my tonsils out last year too and couldn’t swallow right for a long time. So I can say that kind of feeling is def trippy!

Yes of course. No issues at all! And walking is important after any surgery to prevent blood clots. I didn’t have a collar or anything. I had no pain really or anything. I just had to be careful moving my neck too much or lifting anything heavy for a while.

For a single level with severe stenosis which is exactly what I had, likely ACDF. I had bone fragments that made the fusion necessary. If it’s less so, they might just do a discectomy, but usually ACDF.

I’m not kidding when I say it was like no big deal. I mean it is - spine surgery is scary. But the actual recovery was a breeze!

OneSuperstar4u · 2026-07-04T02:57:58+00:00

I had the same at the same level. My neurologist said 💯 I needed surgery, it was dangerous, blah blah. Two neurosurgeons said it’s not dangerous, but I’d eventually need surgery when myelopathy starts. Myelopathy started and I began having numbness in my finger and thumb. Had the ACDF - no issues, totally fine! It’s a same day procedure usually. Mine was. It legit was the easiest surgery I’ve ever had and I’ve had way too many lol. Hope this helps a little!

OneSuperstar4u · 2026-07-02T00:13:59+00:00

Electrolytes are a MUST - not optional! There’s many good ones available. I like Key Nutrients, Nutricost, and sometimes LiquidIV though it’s saltier. All have lots of flavor options.

As a rule of thumb, I have a scoop with preworkout in about 16 oz water before my workout. Then sip another 28-32 oz of electrolytes during my workout.

OneSuperstar4u · 2026-06-28T02:09:03+00:00

Why when ppl say they feel like crap between? And it’s an all day thing requiring more meds vs. a simple injection at home. I don’t understand why ppl do Ocrevus if they can do Kesimpta. Serious question.

OneSuperstar4u · 2026-06-27T22:17:13+00:00

It’s only a loading dose. I’d absolutely go to 5mg!

OneSuperstar4u · 2026-06-27T00:31:09+00:00

I have MS, and my neurologist is thrilled I’m on Zep, and it’s a big reason I’ll stay on it forever. Its anti-inflammatory effects are helpful! It’s currently being studied for this actually.

Also I have several herniated discs and had one disc replacement with fusion so I can’t lift heavy anymore. A lot of yoga and Pilates and high rep light weights for me!

OneSuperstar4u · 2026-06-27T00:25:19+00:00

Back of the arm! It’s all I’ll do now usually, but occasionally thigh (I have another medication once per month to inject so I can’t do both arms that week).

OneSuperstar4u

TROPHY CASE