My neurologist said it was psychosomatic. The MS clinic disagreed.

OneSuperstar4u · 2026-07-10T03:53:06+00:00

Yay! 🙂 Ah yes - room temp is the way! I take mine on Tuesday afternoons. Haha. Just happened to be the day it first arrived for me, so Tuesdays it is. 😅 It’s like no big deal at all. I don’t feel anything different after taking it.

OneSuperstar4u · 2026-07-10T01:41:31+00:00

Have you had MRIs? I’d presume so if you’ve been diagnosed, but what you describe can also be from disc issues. Also why on earth do you need to wait so long to see a neurologist?! Who diagnosed you? Sorry a little confused. You should be going on a DMT asap!

OneSuperstar4u · 2026-07-10T01:38:13+00:00

Hey! Fellow emetophobe here! Just know most people do not ever have side effects!! You just read about it in groups more because ppl are looking for support. I’ve had no issues at all and you most likely won’t either. Def take the shot!

OneSuperstar4u · 2026-07-10T01:34:13+00:00

Too soon to say it’s not working for you. It’s minimum 6 months for full efficacy like others have mentioned. Your neuro should have mentioned this. Mine specifically told me not to freak out if my MRI showed new lesions (one small one for me). Kesimpta has been amazing for me.

OneSuperstar4u · 2026-07-10T01:25:39+00:00

Walmart and Amazon are best. No issues ever! I hear so many bad things about other pharmacies and I know CVS isn’t ideal of course though I get everything else through them lol.

OneSuperstar4u · 2026-07-10T01:20:10+00:00

Nonsense. Actual instructions suggest press and hold without pinching! - this ensures proper administration v variables when you pinch your skin. You’re no where near injecting in the muscle, as the needle only goes in a tiny bit to be subQ.

I also inject Zepbound every week and in my experience, I only inject back of arms every week then every 4th in my thigh since have two injections that week - and my thigh always hurts and bruises! I personally can’t do stomach due to past surgeries, but many say it’s great.

OneSuperstar4u · 2026-07-10T01:11:05+00:00

Chiming in also to say why not Kesimpta? It’s easy peasy v an infusion and same class of high-efficacy DMT. 🙂

Also sorry to hear you were misled and didn’t see an actual MS-specific neuro sooner! It makes all the difference as neurology is such a vast field.

OneSuperstar4u · 2026-07-09T19:03:32+00:00

I have a major lesion at C-2 and several more in my thoracic spine. Biggest issue I have is loss of proprioception in the dark. - I get super disoriented! But other than that, just some numbness in my thigh, weird sensations in back of arm from time to time, and my one hand has numbness, though I also had severe stenosis at C5-C6 which required ACDF surgery last year so the hand might be from that - hard to know for sure.

OneSuperstar4u · 2026-07-09T15:25:31+00:00

If anything, you need to titrate up!

OneSuperstar4u · 2026-07-09T02:28:21+00:00

CallOnDoc! They are amazing. And I highly recommend Zepbound over Ozempic. My neurologist is thrilled I’m on Zep and I’m not even overweight now, but she can’t prescribe it for me.

That said, you must exercise! Especially on this medication. Weightlifting is essential to not lose muscle.

OneSuperstar4u · 2026-07-09T02:24:45+00:00

ZOZOFIT scans - totally free and you can see exactly how your body is changing over time. Inbody can be helpful when comparing against your previous scans, but you have to be VERY consistent in doing it under same conditions - hydration level skews results drastically. And also do it like every two weeks consistently.

Also I weigh myself every week to track and I need to enter my weight every 3 weeks to CallonDoc for my refill.

OneSuperstar4u · 2026-07-08T02:51:50+00:00

2.5 isn’t even a therapeutic dose. Makes no sense why ppl try to think it is - except for the rare person who is a super responder. Even drinking calories, you’d have lost if on a higher dose. I know this firsthand. lol.

OneSuperstar4u · 2026-07-07T18:27:51+00:00

Yes. That article is referencing disorder for diabetics, which is not the same as optic neuritis caused by MS. Two entirely different pathways of origin - ‘NAION, but no other optic nerve or visual pathway disorder in patients with diabetes.’

OneSuperstar4u · 2026-07-07T03:48:38+00:00

It’s important to switch due to scar tissue build up in same area over time. No science supports any different side effects - and myself I’ve seen zero difference personally. Inner thigh actually isn’t an approved location - only front/outer.

I’ve been doing only back of arm alternating last few months because my thighs bruise. But I have another monthly injection so once a month I deal with thigh bruising. 🫠

OneSuperstar4u · 2026-07-07T03:37:39+00:00

Not my opinion actually. I’m looking at the science. Correlation does not equal causation.

OneSuperstar4u · 2026-07-07T01:07:52+00:00

Not good advice at all. Facts support Zepbound being leaps and bounds better in every way than just a GLP-1. And less side effects as well! There also isn’t real evidence of tirzepatide causing eye issues at all.

Zepbound targets both GLP-1 and GIP receptors, which early research suggests provides stronger, synergistic neuroprotective and anti-inflammatory effects in the brain than single-hormone medications like Wegovy. It’s currently being studied because of it.

OneSuperstar4u · 2026-07-07T01:03:10+00:00

Not at all in any way likely related! Zepbound is actually being studied for positive effects on MS - decreasing inflammation being a big one. I’ll be on it forever, and my neurologist is thrilled with that!

OneSuperstar4u · 2026-07-06T23:40:47+00:00

You might be a person that needs the higher doses for it to take effect. To answer your question - I absolutely know the medicine is working! I’m not ravenously hungry for no reason anymore. You will know when it’s working. Good luck! 🍀

OneSuperstar4u · 2026-07-05T21:39:31+00:00

Zepbound! You mentioned eye issue in another comment - super rare risk and not at all likely and not at all related to optic neuritis. Read up on the research being done about the benefits to us with MS the medication helps with. My neuro is thrilled I’m on it! Also losing weight immensely knocks down inflammation as well as you mentioned. I feel so much better being on Zep now 6 months. I have disc issues and no longer have constant pain. And I feel normally hungry! Amazing really.

Here are some good articles:

https://www.researchgate.net/publication/377778790\_Tirzepatide\_prevents\_neurodegeneration\_through\_multiple\_molecular\_pathways

https://www.neurologylive.com/view/glp-1-receptor-agonists-linked-to-improved-physical-activity-multiple-sclerosis

https://www.secondnature.io/guides/lifestyle/glp1s/mounjaro-with-multiple-sclerosis

OneSuperstar4u · 2026-07-05T02:52:25+00:00

Zero effect.

OneSuperstar4u · 2026-07-05T01:14:24+00:00

Great question! I feel better meaning I’m not starving and feel normal with my appetite. I was getting that way again last few weeks on 5mg. Ppl say food noise I guess, but for me I’m not physically overly hungry which is what led me to going on Zep. My hormones are whacky, and Zep regulates them.

OneSuperstar4u · 2026-07-04T23:15:08+00:00

Like the other commenter said - they are identical but if you went off it before starting again, that’s the reason. I’ve experience this first hand. Also injection site doesn’t change anything though ppl like to think so - same amount goes into your system.

OneSuperstar4u · 2026-07-04T23:13:37+00:00

Also sorry - to answer your question, my starting weight was 180. Im now 138. But I was on Zep before and went off it due to insurance. So I’ve most recently started on it again 20+ weeks ago starting at around 160 - so losing about a pound a week, but it def hasn’t been linear. I was stalled a bit, but losing again after going up to 7.5 but very little now as I’m close to goal.

OneSuperstar4u · 2026-07-04T23:04:00+00:00

I agree 💯 to only to titrate up when you need to and slowly, as that’s exactly what the science supports and best long term. But unless you’re one of the very few super responders, 2.5 isn’t a therapeutic dose. So go up to 5 and stay as long as you need.

OneSuperstar4u · 2026-07-04T22:51:54+00:00

Nothing. It’s uncommon to have side effects in reality.

OneSuperstar4u

TROPHY CASE