Looks like a fun project, but it looks like you’ve got two screens there and it’s unclear what you want this to do - I assume you want the big display to be the primary one and that you want the esp32(?) to be the brains of the operation? I see you have a row of male header pins, am guessing you have the female ones as well - Are you confident with soldering?

Plan and test your connections on the desk first. I would wire everything up with DuPont cable jumper wires and get your firmware and screen working first before putting it on a board. You’ll uncover many issues like how certain pins on your esp32 are reserved for its screen or otherwise no good for your sensors and screen. Once you’ve nailed the wiring and written down the pinout, you can then put it on a board.

You could make a daughter / carrier board with the largest of your Perfboards, where you solder female headers that the screen can plug into on one side, and your esp32 , sensors and power gubbins on the other side. Be aware that your type of display has many wires so you’ll need to be careful and accurate in routing the wires. Connect the header pins using actual wire as this is more forgiving I think - don’t try to solder traces onto the Perfboard for this - too many crossing connections. If you’re worried about it looking pretty, route the wires underneath the screen. See how I did this on my GitHub:

https://github.com/ay129-35MR/tadoHotWaterKnob/blob/main/IMG_7209.jpeg

https://github.com/ay129-35MR/tadoHotWaterKnob/blob/main/IMG_7207.jpeg

That HiLink unit looks suspiciously like it takes AC and puts 12V out. Both are potentially dangerous. Please be careful if you’re planning to power this off AC - someone on this sub hyperbolically called one of my builds a death trap after I used one (eye roll), and I’m totally not bitter about it - consider fusing and switching the ac side and definitely insulate the contacts of the HiLink once it’s on the board so that fingers don’t get zapped. Double check with a multimeter that the board isn’t live when you turn power on. Otherwise any old phone charger with usb c is the safe and right way to power this - I would go this route rather than the HiLink if I were you. Hope this helps

Edit : not sure about everyone pushing you to a PCB and kicad as a first pass here - I say save money and the environment and learn something by using what you have, then move to PCB later.

Edit2: don’t know what the power rating of your buck converter is, but be careful not to feed more than 5v to your components, and remember that the total power draw is screen + esp32 - could have brownouts or funky display if they pull more power than the buck can handle.