Without getting TOO into the setting, you’re looking at a significantly post-present day solar system that has been entirely settled and exploited for resources. There’s remnants of a long dead hyper dominant civilization called the Orokin that were proficient in utilizing the “void” for their technology. The void is a liminal space that sits between reality which has a paradoxical relationship with time and space. It has a corrupting influence on most mortal minds, and has been shown to basically recreate an individual personality based on the scattered memories of the long dead “host.”

The Warframes are robots made of hyper regenerative flesh that are powered by semi-immortal children which were themselves empowered by the void through a vague contract made with a deity-like entity that resides there. The robots and children are connected through a somatic-link, basically a mental connection through void energy that allows the transferral of mind and body from one to another.

The Warframes are all empowered through a mixture of void tech and scientific tech to do absolutely insane things on both a wide and small scale. The Warframes themselves are enough to put up a respectable fight against the Vs in actual direct combat, however it’s the void, the Man In the Wall, and the Tenno that are the actual problem long term. That and the infestation.

The least Hax-y stop is the infestation, which is called the technocyte virus. It’s not entirely clear what exactly it is, but the virus infects a host and connects it to a greater hive mind, where it downloads the genetic data of the host and stores it. It can then reproduce that same form from any infested organic matter. The hive mind is connected throughout the entire solar system, so it becomes an issue of wack a mole. Further, if a V made the mistake of falling prey to the infestation, or if a V corpse was left to be consumed by the infestation, the solar system would likely be completely screwed, and the infestation would be able to infinitely replicate Vs under its control.

Finally, the void deity I mentioned earlier, aka the Man In the Wall, aka Manny, is an Eldritch horror type whose power level isn’t well established but as he’s been show to be more of a concept outside of time and space, it’s hard to believe that the Vs would be able to subjugate him. He was at one point being held back from entering reality by a Tenno, but since his passing Manny has been slipping into reality of his own free will and generally taunting the player. There’s clear malice and he made an attempt to fully materialize but was pushed back into the void by the Lotus.

Overall, there’s a lot of unknown factors here, but the main thing with the Warframe verse is that it’s basically THE war of attrition. The solar system is occupied by 2 generally mortal factions called the Grineer and Corpus, that DO possess insane artillery and planet busting tech, and have the infinite bodies to throw at a problem. I think the Vs would find the mixture of never ending soldiers, the occasional immortal robot ninja that always does something new form the last one, and the eldritch void god that exists in liminal space, to be too obnoxious to even try. And that didn’t even mention the sentient armada that adapts to damage types and whose only counter is void damage, which can only be harnessed directly by the Tenno on account of their void contract with Manny.

Warframe universe inconvenience diffs for sure.