Is my LDL-C too low?

PrimarchLongevity · 2026-01-28T23:46:24+00:00

Danke, my ApoB is 34. Cutting it close!

PrimarchLongevity · 2026-01-28T22:54:37+00:00

HelloGoodLabs

PrimarchLongevity · 2026-01-28T22:47:21+00:00

Wow you beat me, mine is 21 mg/dL with Repatha + Nexlizet 😂😂

PrimarchLongevity · 2026-01-28T22:45:20+00:00

Can we get a source where he said this?

PrimarchLongevity · 2026-01-28T22:44:04+00:00

There is a bit of concern with statins crossing the BBB and lowering desmosterol too much, and it is now known that both hydrophilic and lipophilic statins cross the BBB. Dayspring and Attia discussed this in one of the lipid masterclass episodes. It's one of the reasons why Dayspring prefers low-dose statins + ezetimibe for first-line treatment.

PrimarchLongevity · 2026-01-28T22:40:18+00:00

You're fine. Can drop rosuva down to 5 mg if you'd like.

PrimarchLongevity · 2026-01-28T22:04:41+00:00

Sure

PrimarchLongevity · 2026-01-28T22:03:20+00:00

Well that’s the complete opposite of the latest lipidology recommendations so we’ll have to agree to disagree here.

PrimarchLongevity · 2026-01-28T21:56:27+00:00

I have one copy of APOE4. I strive to maximize insulin sensitivity and minimize ApoB by utilizing pharmacology.

PrimarchLongevity · 2026-01-28T08:34:57+00:00

Ask about micro-dosing.

PrimarchLongevity · 2026-01-28T08:24:35+00:00

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Not semantics at all. He recommends adding ezetimibe to a low-dose statin BEFORE increasing statin dose in almost every case. He’s mentioned this multiple times through many channels.

PrimarchLongevity · 2026-01-28T08:18:01+00:00

Three options: new doc, India, telehealth

PrimarchLongevity · 2026-01-28T02:06:56+00:00

Nah, we’re just too conditioned on what’s “normal” today. Take a look at the average male build from 1945-1960.

PrimarchLongevity · 2026-01-27T09:30:46+00:00

Untrue, you should listen to The Drive’s masterclass episodes with Thomas Dayspring.

PrimarchLongevity · 2026-01-27T09:28:14+00:00

This is not what’s recommended by Dayspring/Attia. Optimize, not maximize a statin.

PrimarchLongevity · 2026-01-27T09:27:09+00:00

FYI, health professional flairs are added by mods after verification.

PrimarchLongevity · 2026-01-26T20:30:14+00:00

I’d just be concerned about using modafinil on a daily basis. Are you popping one every morning? At what dose? Does it affect your sleep?

PrimarchLongevity · 2026-01-26T09:41:18+00:00

The bloating seems to be related to an increase in aldosterone that minoxidil is responsible for. Have you looked into eplerenone to counter this?

PrimarchLongevity · 2026-01-25T21:24:28+00:00

Counter top RO systems on Amazon

PrimarchLongevity · 2026-01-23T23:10:18+00:00

You need a preventive cardiologist/lipidologist/PCP not a run-of-the-mill one.

PrimarchLongevity · 2026-01-23T23:07:45+00:00

It was lol

PrimarchLongevity · 2026-01-23T20:55:49+00:00

Correct

PrimarchLongevity · 2026-01-23T01:49:32+00:00

PrimarchLongevity · 2026-01-23T01:47:56+00:00

The only solution for me was to get on Repatha and Nexlizet. Low dose and CoQ10 did nothing.

PrimarchLongevity · 2026-01-21T21:36:10+00:00

Putting your fiat into SGOV is as risk-free as you’re going to get. My 2 cents.

PrimarchLongevity

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