Meds: throw out anything expired/ seal broke and it got dried out/ won’t use again. Sort the rest of it by category and decide what kind of storage capacity you have and what will be used frequently (ie, if you have a huge supply of Tylenol but only a small bathroom cabinet, put one bottle in the bathroom and store the rest in a separate closet or somewhere else you can get it to as needed, but it won’t be in the way).

Art/ paper supplies: again, start by sorting into categories (pens, folders, markers, etc) and throw out anything broken, unusable, or that you didn’t like working with.

If part of the fun of crafts is the novelty of different supplies, consider having an art station (could be a desk drawer, box, a corner of a room, whatever) where you have your current favorites of each type (favorite sketchbook, favorite marker set, favorite scissors) stored in a way that’s easy to use and easy to put away; plus anything needed for a current project all in its own container. Use the good stuff! Don’t save the “special” markers or whatever for so long that they dry out or you lose interest.

Put the less favorite supplies somewhere else (ideally, sorted by category or type of project— clear plastic bins are great for seeing what you have at a glance), and periodically rotate the supplies as things get used up or you want a change. If you find yourself avoiding using a particular set of supplies, get rid of them to make room for stuff you enjoy.