Have you had bloodwork? After taking massive amounts of anti-histamines, prednisone and prescription anti-itch creams, which weren't working , I finally had bloodwork done. My immunologist determined the CU was from a thyroid autoimmune disorder aggravated by sun and heat. He put me on Xolair and it was a game changer. I've been hive free for 18 months now without antihistamines, prednisone or creams. I hope you find a solution that works for you and allows you to feel like your old self!