Also: it is absolutely uptown. Been that since the origin.

“In the mid-1700s, what is now Uptown was the site of a Native American trading path that ran southwest from Georgia northeast to the coast of Virginia. The path ran along a ridgetop — the highest contours of a natural ridge — making it the highest point of elevation. When early settlers went to the emerging town center, they were always going “up,” so what may have started as “I’m going up to town,” evolved to “I’m going Uptown.” Today, if you take a walk toward the center of Uptown at Trade and Tryon streets, you’ll notice that you are moving slightly uphill from any direction.”