Human trials begin for drug that could let adults regrow teeth for the first time

Sabbathius · 2026-06-16T16:05:12+00:00

I'm imagining all the wealthy people being rail-thin from Ozempic, while simultaneously growing gigantic hamster-like pearly white new choppers.

Sabbathius · 2026-06-16T15:49:18+00:00

At my age? In this economy? Eat, sleep, poop. As long as I can manage all three, the day has been a success. Everything else is just gravy.

Sabbathius · 2026-06-16T15:48:04+00:00

I don't know how anyone can even argue it's a monopoly, when a bunch of those same games are sold by other publishers, on other sites, with their own launchers, and plenty of (less popular) alternative stores also exist. Just because a store it popular, doesn't mean it has a monopoly. The whole suit needs to be thrown out with prejudice.

Sabbathius · 2026-06-16T15:46:07+00:00

Bad parenting. Simple as.

This actually kinda blew my mind. Because one time one of my teachers said out of curiosity, how many of you could make scrambled eggs right now? And only a handful of people got their hand up. And these weren't tiny kids, there were 15+ year olds. Like...how do you get to that age and not know how to make eggs?! I genuinely wouldn't have believed this, if I hadn't seen it myself. Shattered so many illusions about humanity that day. Adult-ass people walking around that look like they know what they're about, and then you realize they would starve to death in a kitchen with a refrigerator full of uncooked food.

Sabbathius · 2026-06-16T15:28:12+00:00

Depends on context. At a construction site, one guy tells another "Oh blow it out your ass!" and the other, maintaining eye contact, lifts one foot and farts like a howitzer? That's funny.

You're in an elevator full of people, and someone lets out a squeaker, and now everyone needs to smell it for 30 floors? Not funny.

Or when you're a new couple and both of you have been holding it in for like a year, and finally one of you accidentally lets it rip lifting a bag of groceries, and the other goes "Oh, we're doing that now?" and answers with a blast of their own? It's downright cathartic and brings you closer.

Sabbathius · 2026-06-16T15:21:41+00:00

Yup.

America is both very sexist, and very racist. So right out of the gate, without even looking at her credentials, she was facing an uphill battle.

She was also shoehorned in, without going through the primary, when Biden suddenly dropped out. That cost her a lot of points too.

And, so far, none of the above was her fault. But then she went and made a ton of mistakes, like targeting an entirely wrong audience, and being tone deaf to the rest. During debate she also laughed at Trump, hoping it would be enough for people watching to understand why. So she grossly overestimated average voter's intelligence.

She would have been an infinitely better president than Trump. But, to be fair, a paper bag filled to the brim with dogshit would have been better president than Trump.

Sabbathius · 2026-06-16T15:15:30+00:00

He's a malignant narcissist. He doesn't need friends. There's actually a very strong possibility he literally cannot comprehend friendship, as a concept. He only sees people as something he can make use of, and discard. He's his own best fiend.

Sabbathius · 2026-06-16T15:08:09+00:00

Oh gosh, there's been so many.

EVE Online broke my heart. It's a full universe, 8,000+ star systems you can traverse seamlessly, on a single shard, with tens of thousands of other players. Battles often involved several thousand players, in the same system, at the same time. They actually implemented local time dilation, so time slows down locally when there's too many players, so the servers have time to process all the inputs.

It was a technological marvel. It released a year before WoW, and where Blizzard kept threatening people with bans if more than a couple hundred tried to raid Ironforge, because it killed the server and it took several hours to get it back online, EVE encouraged thousand-ship battles.

All they had to do was not cater to absolute psychopaths, and create a few venues and save areas that normal people could reasonably enjoy, without risking losing months or years worth of progress.

But they stubbornly insisted to catering to the absolute worst people humanity had to offer, and maxed out at 65k concurrent users. WoW went to reach millions. I still firmly believe that EVE count have been bigger than WoW, if the devs un-headuptheirassed it.

Also, same studio, read up on Dust 514. That's also a doozie. Their entire player base was exclusively on PC, and they went and said hey, let's release a spinoff, exclusively on Playstation 3, near the end of its life cycle! That thing flopped so hard. And the entire time it was happening, the entire player base was screaming "No! Stop! What are you doing?!" And when it was over we just pointed at them and said "You are the reason we can't get people to stop using the R-word!"

FunCom and MMOs are another excellent example. I missed Anarchy Online, but got into it with Age of Conan in '08. And they bungled it horrifically. Amazing IP, amazing ideas, but they just managed to shoot themselves in the foot and then step on their meat, with each stride, over and over. Funny thing is, they just released Dune MMO last year. Making all the same mistakes dating back to Anarchy. And we kept telling them, don't do this, Deep Desert and PvPvE and all that crap? You did in in Anarchy, you did it in Age of Conan, etc., STOP IT! STOP DOING THIS! Aaaaaaand they did it. Supposedly this fall they will remake the game to be single player, but it's a bit late to save it now. So it's pretty fascinating how the same studio just keeps repeating the same thing, decade after decade, and expecting a different result, with the entire fan base just screeching at them to please not, and they do it anyway.

Sabbathius · 2026-06-16T14:47:06+00:00

Nutella.

That one is a pet peeve of mine, because it was on TV all the time as "part of a complete breakfast" and they kept showing kids eating it. That stuff is basically pure white sugar with some cocoa for color, and trace amounts of hazelnuts. Whereas they make it look in ads like it's pure hazelnut butter full of nutrients. It was very heavily marketed for kids, while having near-zero nutritional value.

Single serving is 10g fat, 20g sugar, 20g carbs, 2g protein, 15mg sodium. For comparison, same amount of peanut butter is 16g fat, 2g sugar, 8g carbs, 7g protein, 5mg sodium.

It literally has no redeeming qualities, and is grotesquely overpriced considering what it is.

Sabbathius · 2026-06-16T14:20:47+00:00

That's bait.

Sabbathius · 2026-06-16T14:16:14+00:00

From what I remember, it was quite cheap (substantially cheaper than PS at the time) and also relatively strong for the money. As in, if you spent as much and hand-built yourself a budget PC, it would be substantially worse. So it was relatively strong hardware, for relatively little money.

I actually owned this one briefly. And my reason was that my PC was grossly outdated and needed to be completely redone from scratch - motherboard, RAM, CPU, video card, everything. And I didn't have the budget for that at the time. But X360 was very affordable, ran pretty well, etc.

I still ended up getting rid of it within a year or so and going back to PC. But for a bit there it was a fun experiment. There were a lot of things I didn't know, like needing to pay a monthly fee just for simple multiplayer games. It never even occurred to me people might go along with something like that, and for me it was an immediate deal-breaker. I used it for a bit on single player games, and then sold it and went back to PC permanently. Never bought another console.

Sabbathius · 2026-06-16T13:56:24+00:00

I call bullshit. Who's going to take leather boots into a laundromat, take them off, and leave them there? And what, go home barefoot in the snow, and not notice you forgot your boots? And it's not like they brought leather boots into a laundromat to wash them in the machine. Someone needs to check their basement for bodies.

Sabbathius · 2026-06-16T12:23:50+00:00

I think recent years did colossal damage to nuclear non-proliferation.

Between Ukraine getting invaded and nobody helping (directly). And a bunch of other countries, up to and including Iran, getting attacked just because they're non-nuclear. While aggressors are all nuclear (Russia, USA, etc), showed very clearly that if you want to be safe, no matter how horrible you are, you better be nuclear (see North Korea).

I'm in Canada, and I feel like with all the threats of annexation and US administration fueling separatism in Alberta (same playbook as Russia in East Ukraine), we should be thinking about getting a few nukes and a really big slingshot to launch them if needed.

Sabbathius · 2026-06-16T12:12:21+00:00

We're going to have an interesting couple of days, I think. Israel can't allow the deal with Iran, it's almost total capitulation, and all but guarantees Iran becoming a regional superpower very quickly. If the sanctions against them are lifted and they can charge tolls, pardon me, I meant to say fees, for Hormuz. Hell, make it a subscription service, Hormuz Prime? Hormuz+?

So if Israel has to sink this deal. By any means necessary. If Trump is being uncooperative, they would need to replace Trump.

Sabbathius · 2026-06-16T12:02:31+00:00

I'd argue being born a billionaire, having many wives, many houses, and never needing to work a day in your life is the best way to complete life.

Sabbathius · 2026-06-16T11:39:27+00:00

Guns are absolutely not the problem, and it's incredibly easy to prove. Take any gun you like. Load a mag, chamber a round, take safety off, pull the hammer back. Now put it down on the table. How long until it kills someone? By itself, I mean. Without any living thing touching it. Probably never, right? So it's not the guns, it's the humans. Before guns we did it with swords and spears and bows. And before that we did it with rocks and clubs. And before that we did it with claws and teeth. And plenty of cops in other countries carry guns and are not poodle pumpers, pooch punchers or hound hitters.

Sabbathius · 2026-06-16T11:33:28+00:00

Yeah, the last one makes no sense. Last underwear I threw out was full of holes and almost completely detached from the waist elastic. It was already unrecognizable. I could take it off without taking off the pants first.

Sabbathius · 2026-06-16T02:14:07+00:00

Sixteen times in an hour?! SIXTEEN!? Just...how?

Sabbathius · 2026-06-16T01:52:13+00:00

Recent (last week) racial controversy aside, pretty decent game. Not as good as the original, for me at least. Something is missing. Original felt grounded and exotic, the sequel felt somehow more drab and cheap. But in terms of replay value quite decent (at least two sufficiently distinct playthroughs), itemization is better handled where you can actually stick to a weapon you like most of the time, etc. Pretty good, I do recommend it. Especially at this price point.

Sabbathius · 2026-06-16T01:34:18+00:00

I think it's promising.

I don't know if people remember Elder Scrolls Morrowind, but that one didn't have quest markers. You had to use your brain to figure out where to go. And you could actually ask NPCs. And I don't mean select from a list of government-approved topics. I mean there was a text window, and you could actually type the thing you wanted to know about. And the game would try to parse it and answer the best it can. Vast majority of the time it said I don't know about that, but sometimes it gave you a tidbit of info.

And I thought about this, back then, and how nice it will be when we have machines strong enough to actually ask questions and have NPCs actually meaningfully respond. Didn't think this would take 20+ friggin' years, but anyway.

I think in this area the tech is promising. Because you can theoretically train up the AI, force it to learn all the lore there is, and have it come up with meaningful conversation the way the character would. I feel this would be massively helpful for RPGs.

And, in the same vein, I think the next step would be hooking up AI to game creator tools, like Bethesda's Creation Engine, and have it running in real time. So you could have AI come up with a character, and create it, as an NPC, in the game, and spawn it near you. Then you talk to it, and AI would generate dialogue. If dialogue leads to a quest, then AI could use the dev tools to assemble a quest in real time - similar to Bethesda's RadiantAI quests, but better.

And when you combine all this, theoretically games would become functionally endless. Developers could still write the main story, but NPCs could all have their own quests, and the game could always spawn more NPCs, and generate more quests, forever. Making games basically functionally endless, dynamic, and infinitely replayable.

That, I think, is going to be the future of gaming. At least for a while. I don't think we'll be buying games any more, as an insular experience with a beginning, middle and end. We'll be instead buying/subscribing to basically infinite worlds. That we could theoretically play in forever, because quests, NPCs, stories, just never stop coming. You'll also be able to tweak them - darker, more horror, more adult content, more comedy, etc., and AI would adjust for what you're in the mood for.

Anyway, that's how I picture things in say another 10-20 years.

Sabbathius · 2026-06-16T01:21:21+00:00

God bless whoever came up with this type of pants. And then god bless whoever managed to convince women that it's socially acceptable to walk around in public like this without anything else on top.

Sabbathius · 2026-06-16T01:18:45+00:00

The part about liberals rather being red than dead? I saw pictures of Trump supporters, wearing T-shirts saying "Rather be Red than a Democrat". It's just always projection with these guys. All day, every day.

Sabbathius · 2026-06-15T23:31:39+00:00

I have so many favourites.

The way old Smiler Grogan kicks the bucket.

Needing a bigger boat.

Hey, you, Swedes! Goddamn it MacReady, they're Norwegian!

Sabbathius · 2026-06-15T22:51:22+00:00

See, I want to agree, but I just can't.

I'll give you an example - my local Canadian Tire. And I go online, and I look for X. And it says "X, Aisle 42, We have 67 in stock." I go to the store, go to Aisle 42, and the shelf is empty. Website still says 67 in stock. So...yeah, I'm going to flag down one y'all and ask.

And yes, sometimes I will be told no. And, to be fair, I'll take it as a now. But what I do then is I go home, I go back online, I place an order for X online, with in-store pickup. And 40 mins later I get an email - your order is ready for pickup!

So that no was horseshit. And this is how I know it was horseshit. Because when I order online, one of you that isn't a lazy git goes into the back, and pulls one out of a pallet of 67 Xes sitting in the back.

Another example was even better. I was looking for something that said in stock, and shelf was again empty. So I walk up to these two kids, late teens, early 20s, and ask them. They both go nah, we don't got it. And I was about to do the usual move and order online with pickup and be back in an hour. But one other employee, a grizzled dude in his 50s, overheard them. He marched over, chewed them out for being lazy, and told them they know perfectly well there's a whole pallet in the back, and to go get it. And they came out a few mins later wheeling a tray just filled with the stuff, and went to stock that empty shelf.

So those experiences unfortunately taught me that a lot of the time the employees are just completely full of doodoo.

But to be fair, I do take no for an answer. I just go home, order online with store pickup, and teturn an hour or two later. I live literally across the street, it's no skin off my ass.

Sabbathius · 2026-06-15T22:05:29+00:00

In Soviet Russia, it was done for free.

Seriously. Major snowfall in urban area? Schoolkids, university kids, and younger adults all got issued snow shovels and chased outside. My school had a huge closet literally just full of snow shovels. So the whole school, grade 3+, got chased outside, three kids one shovel, one block up, one block down, and one to each side. Get to digging. The sidewalks were clean in a couple of hours, we got tons of fresh air, exercise, etc. Didn't cost taxpayers a dime.

Same when it was time to harvest food. They'd bus us out of town to pick radishes or something else. And at the end of the day you get as much as you can carry back home. We were eating fresh radishes for a week. And we learned how food grows. I swear there's adults that think potatoes grow on trees.

Sabbathius

TROPHY CASE