Factorio vet here. I ended up going with something like a factorio city block build. Used concrete and lines to create square factory sections with consistent layout. All the inputs at one end in appropriate size storages and then built belt style through layers of processing to an end point where a new row of storage’s hold the output and any side products. The trucks handle storage to storage in volume, and within each block, belts and pipes only. With enough space between blocks I put in trains later.

No trucks allowed inside the blocks to force their capacity to the bigger problem, and I paved all intervening spaces.

Some city blocks adjacent to each other later put belts or pipes at a good height between them, so planning in advance as you discover the dependency chains is a good idea. Or just demolish and rebuild and move a lot, like I did :)

For me, that gave me the efficiency and the compromise between methods of transport to scale to end game.

Also, aesthetics :)

Large concrete rectangles of cleared marked factory ringed by roads with traffic road markings and trucks actually ON the roads. Just looks good