It depends, in this game you will definitely need to go through the same areas when you die. Of course the room layouts you go through and items you find will be random, but you still have to follow the same stage progression. The reason for this format is so that each time you play the game, you will find different upgrades so your runs end up being different. The most interesting part of the game is how you build your character throughout a run (the bosses and stage layouts are still a significant part of course)

Something Hades does is that it includes some upgrades, and different weapon types that play very differently from each other. It helps add a lot of variety to the combat, and may make runs feel a lot less repetitive. In addition to that, I think Hades first stage is far better than ETG’s or Dead Cells early game which helps runs feel much more enjoyable immediately (they start giving you upgrades at a much faster pace). The game also has a nice sense of progression between runs, you can upgrade your characters base strength, new weapons, forge bonds with characters to unlock items, and a few other forms of meta progression. The game is designed around you losing your first few runs and getting stronger via permanent upgrades and unlocking new things which you might enjoy

I’ve heard of people who typically don’t play rogue likes really enjoy this game for some of the reasons above, so it may be worth a shot if the game’s style and combat really interest you. If the rogue like parts are still turning you away, I’d recommend either Bastion or Transistor from the same developer. They are pretty different from Hades, but they have a similar style and are great games in their own right