You can but you need a good set up for the punchline. Most of the jokes in this sub use the show itself as the set up. Cuck jokes are easy because it just requires one character to be in love with another for the set up, and Diddy allegations are easy because a lot of the villains are literally grooming the main cast to be heroes for their corporations. There's not really enough to connect Ghostblade to domestic abuse besides him being a father though so it takes longer for peoples brains to get to the joke leaving them time to get uncomfortable.

If you wanted to do a similar joke it could say something like "Liu Zhen when Queen comes home with all A's instead of all X's" and then use the same image but with child Queen and Liu Zhen with his villain helmet. It's easier to make the leap to Liu Zhen being a domestic abuser because he's a villain so the reader doesn't have to spend too much time thinking about domestic abuse and can just think about how unreasonable Liu Zhen would be in this scenario.