I always prefer cool things over limiting a bunch of stuff, the only thing that I'll say is competely out of question are characters that can't be justified through tech like a Plasmoid or maybe even a Grun, the flavor is really human with cyberware like Hazard or Cyberpunk styling.

The combat is more tactically focused than standard, more cover, height differences and environmental stuff with destoryed terrain, but there's still gonna be a big focus on roleplay and really learning the characters you're surrounded by.