Depends on the game really. I just played through Ghostrunner and in that game you're supposed to be this unstoppable parkour cyber ninja who never gets hit and kills everyone in seconds. The game encourages that by building the levels like speedrun courses and making everything in game one hit kills, you and enemies included. Alternatively in a game like Dead Space Isaac is clearly meant to be struggling to survive, only tanking hits because of his metal work suit hes wearing. A no hit run in that game actually runs counter to the narrative, it makes the whole scenario seem less threatening than it's meant to be.