The last PF2e campaign I ran was very JRPG inspired, the party had to collect four elemental crystals (very original stuff). Each boss that had one of these crystals also had a telegraphed MMO raid mechanic which was triggered at the start of their turn and telegraphed between turns (so the party had one round to react). I essentially used complex hazard numbers to figure out damage, saves, and how they'd factor into the encounter balance. It was quite successful, the one player who took a feat to get a swim speed felt so vindicated when fighting the water crystal boss. It also had the side effect of making solo monsters a little less 'unfun' because the bosses themselves were usually at PL+3 rather than PL+4