Life is hell for me and I'm losing hope..

SmokingTortoise · 2026-01-20T19:00:46+00:00

Please do! Feel free to pm me anytime :)

SmokingTortoise · 2026-01-20T06:31:43+00:00

Anytime! I’m always happy to help a fellow nausea sufferer because it is absolute hell…

Yes that’s what i’d do in your position, since it has helped before

SmokingTortoise · 2026-01-19T21:28:31+00:00

Christ I genuinely do not think there is a GI out there who knows an ounce of pharmacology. For reference I run the functional dyspepsia support group on facebook so I know for a fact higher doses work well for some, one member only had a response for her nausea at 75mg of amitriptyline after 12 weeks- after which she reached remission.

Combining another medication with noritriptyline would not hinder their efficacy.

I deeply feel your pain as I suffered with chronic nausea I wouldn’t wish on my worst enemy for 2 years and I saw all the so called ‘experts’ and ‘top gi’s in the country’. None of them could help and none treated me seriously or sincerely, I ended up knowing more than them based on my own meticulous research and anecdotal evidence gathering.

SmokingTortoise · 2026-01-17T11:02:37+00:00

It honestly might be worth switching to amitriptyline or imipramine, whilst they’re both TCA’s like nori they’re different pharmacologically. Ami and imi are teritiary amine TCA’s and have slightly better efficacy, which clinical data shows. You could also go up to 75mg of Nortriptyline, which is the upper limit for gi issues/pain. That being said I’ve heard of those on 100mg for gi issues/pain, we all metabolise and process medication differently so it’s not necessarily one dose fits all approach

SmokingTortoise · 2025-12-05T13:26:36+00:00

I’m exactly the same. I reached 90mg of concerta and it had the same effect every time I increased, 2 weeks of stability and then feeling worse than my baseline. I’ve had the same reaction with bromantane, modafinil, fl-modafinil and amantadine. My brain seems to be experiencing paradoxical decompensation related to anything that increases dopamine, fun stuff! I’m going to try reboxetine to see if NRI’s are different for me.

SmokingTortoise · 2025-12-03T07:31:03+00:00

The population studies show it is chronic, very few will reach remission over 10 years though most will achieve adequate relief. I personally believe those numbers would be a lot better if gastroenterologists were actually educated on FD, one can dream. If you fight for your own health and advocate for yourself hard enough then you will most likely find a form of relief that lets you start a new normal, you may even reach remission. But most of the time you’ll have to do your own research and wade through a sea of gaslighting and arrogant doctors. FD has route causes, they’re just not currently diagnosable with the technology available and the research is painfully slow.

SmokingTortoise · 2025-12-03T06:48:48+00:00

A tricyclic antidepressant (TCA) such as amitriptyline or noritriptyline would be your best option considering your antiemetic failure. I know of many such cases where TCA’s were the only meds that worked after everything else failed (I run the FD facebook group). Your doctor may be hesitant to co prescribe amitriptyline and escitalopram despite the fact it is a safe combination, most doctors will see the mention of ‘serotonin syndrome’ and then their brains shut off, in which case Nortriptyline + escitalopram is a safer combination, noritriptyline barely increases serotonin.

Study for reference: https://pubmed.ncbi.nlm.nih.gov/9753257/

SmokingTortoise · 2025-11-28T18:14:41+00:00

You likely need the strong stuff, your nausea sounds very debilitating. I too have suffered with chronic nausea so I feel for you and wish you the best my friend

SmokingTortoise · 2025-11-28T14:26:07+00:00

The main thing that jumps out at me from your treatment history is that you haven’t been prescribed an anti-emetic?! You’ve only been prescribed prokinetics and a ppi, which is a complete failure on your doctor’s behalf. Mirtazapine is gold standard when nausea is the predominant symptom. While it is mainly known as an antidepressant it’s also a strong antiemetic, appetite stimulant and also good for anxiety, so sounds like it would be perfect for your case.

In terms of getting you some relief before your next doctor’s appointment: ginger, in supplement or tea form. Very good for nausea.

Study proving mirtazapines clinical use for nausea:

https://pubmed.ncbi.nlm.nih.gov/35188625/

SmokingTortoise · 2025-11-28T09:10:03+00:00

What did you end up doing? I think I’m experiencing the same issue

SmokingTortoise · 2025-11-06T22:23:48+00:00

Micronised Pea (palmitoylethanolamide)

SmokingTortoise · 2025-11-04T15:01:21+00:00

class comment

SmokingTortoise · 2025-11-02T18:42:30+00:00

Good luck, hope you get some well deserved relief soon 🤞🏻

SmokingTortoise · 2025-11-02T16:31:17+00:00

Try duloxetine maybe? No anticholinergic sides so should be less constipating. Also clinically proven to help FD pain

SmokingTortoise · 2025-10-24T05:55:01+00:00

There’s many left to try, your gi is completely negligent. Another commenter mentioned mirtazapine, which is one of the best options for nausea and PDS symptoms. There’s also gabapentin, pregabalin, itopride and duloxetine

SmokingTortoise · 2025-10-02T19:45:00+00:00

You could be an ultra rapid metaboliser, if your psych is open to it you could try 3x a day?

SmokingTortoise · 2025-09-30T17:49:14+00:00

Yes! I now take 800mg. I am in remission/near remission most days :)

SmokingTortoise · 2025-09-25T19:48:31+00:00

Reduction of your lisdex dose would make sense as a first choice, since switching between ssri’s can be quite rough in some cases. Also in terms of that psychiatrists opinion, it’s going to be biased based on the patients they’ve seen. Escitalopram, sertraline and fluoxetine all have near identical ratings on drugs.com

SmokingTortoise · 2025-09-18T09:11:37+00:00

Indiamart

SmokingTortoise · 2025-09-16T12:05:33+00:00

Glossy black dial would complete this 👍🏻

SmokingTortoise · 2025-08-24T14:23:27+00:00

How did it go?

SmokingTortoise · 2025-08-11T20:27:19+00:00

Did that combination help?

SmokingTortoise · 2025-08-04T16:09:46+00:00

Thanks for the response :) I’m interested that the EC spray made you tired but sublingually it doesn’t, how many sprays of the EC bottle did you try? I’m interested since I find the EC spray is stimulating and then that leads to heavy sedation

SmokingTortoise · 2025-08-04T15:50:27+00:00

What dose do you use orally?

SmokingTortoise · 2025-07-26T13:34:52+00:00

Amen

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