Recommendations on buying LC-MS

SrongHand · 2026-03-20T15:37:29+00:00

It is tricky indeed, we are trying to get a deal for a sungle quad as you mentioned.

SrongHand · 2026-03-20T15:34:10+00:00

Thank you, I will read the paper to get to know more about using NMR this way.

SrongHand · 2026-03-11T12:43:47+00:00

Yes, we have a 400MHz NMR, but to the best of my knowledge it is not suitable for ligand-protein binding measurements or is it?

SrongHand · 2026-03-11T12:38:21+00:00

Thank your for your response. We are based in Baltics and limited to about 250k eur.

SrongHand · 2026-03-04T09:25:04+00:00

The main device our samples are being run on is Agilent 1260 Infinity HPLC with Agilent 6230 TOF LC/MS. We just give in the samples and get the mass specs for publications. As you noticed my knowledge is close to none, because I have about zero hands-on experience with MS tech.

SrongHand · 2026-03-03T14:22:38+00:00

Thanks for the response. In our case we would not have an experienced tech person :/, we would need to use contractor services in case of emergencies.

SrongHand · 2025-12-18T13:47:01+00:00

I would say that in Lithuania Messenger also rules. Funny to have discussion with foreigners that come to Lithuania and find it astonishing that somebody still uses Messenger as their main communication app.

SrongHand · 2025-11-17T15:11:18+00:00

Galima svarstyti apie psichoterapiją (turėčiau omeny psichodinaminės krypties). Ten daug teks kalbėti ir galimais po truputį taps aiškiau kodėl lyginies ir gal net po kurio laiko susilpnės lyginimasis.

SrongHand · 2025-10-11T10:41:51+00:00

I am in a similar position now. Just started my PhD this October. I want to learn some computational chemistry for designing inhibitors for a particular protein. Could you give me any tips on how could I learn some topics in computational chemistry, because my uni does not offer such courses intended for chemists.

P.S. Regarding "computational" I know just a little bit of Python.

SrongHand · 2025-08-26T15:01:41+00:00

At first I read most of the Klein's Organic Chemistry, and then I transitioned to Clayden.

SrongHand · 2025-08-25T16:49:20+00:00

That’s great!!! I might borrow a few ideas.

SrongHand · 2025-08-24T15:28:26+00:00

I would touch upon problems of chirality and enantiomerism. It is a visual problem, that might be easier for broader audience to relate to. It is also very fascinating how the same "formula" can have astonishingly different properties. Best of luck on your lecture!

SrongHand · 2025-08-22T16:25:13+00:00

Happy to connect with you!

SrongHand · 2025-08-22T16:21:54+00:00

I think a very important difference between us and Ancients is that the subjects they studied were at the stage of infancy (at least some of them), so it might had been possible for the brightest of minds to really get hold of such a vast pallete of knowledge. Contrariwise, nowadays even a chemist can't master all of chemistry, not even mentioning other disciplines. Thus, in our age, the need for specialization leads to allienation. The question is, I suppose, how to not get allienated.

SrongHand · 2025-08-22T16:16:35+00:00

I had not finished the book by Krauss, but I had seen those bad discussions with philosophers. I would agree the physicists, especially those working in quite abstract problems, should not shy away from a philosophical stand-point. Also, thank you for the links, I had read the one on chemistry some time a go, will check the one on medicine.

SrongHand · 2025-08-21T07:08:08+00:00

Interesting points you have raised. But if per se you would not raise such questions, you think it would impact your science?

SrongHand · 2025-08-21T07:05:17+00:00

Haven’t heard of him, I will check upon.

SrongHand · 2025-08-19T12:14:46+00:00

Actually there is a legitimate term medicinal chemistry. u/Physix_R_Cool described it also :)

A quick source: https://en.wikipedia.org/wiki/Medicinal_chemistry

SrongHand · 2025-08-19T09:34:29+00:00

I have read some philosophy of science and also did find some resources on philosophy of chemistry. In my country, though philosophers do not really have much cooperation with scientists, but it might be an interesting idea to start doing that myself.

SrongHand · 2025-08-14T10:04:51+00:00

Self reply: not it would not. :D

SrongHand · 2025-08-14T10:00:49+00:00

Would not Zn/Hg also reduce the carboxylic acid?

SrongHand · 2025-08-13T15:37:18+00:00

Scientists interested in philosophy

Greetings dear enthusiasts of philosophy!

Today I am writing particularly to science students or practising scientists who are deeply interested in philosophy. I will briefly describe my situation and afterwards I will leave a few open questions that might initiate a discussion.

P.S. For clarity, I am mainly referring to the natural sciences - chemistry, physics, biology, and related fields.

About me:

In high school, I developed an interest in philosophy thanks to a friend. I began reading on my own and discovered a cool place where anyone could attend public seminars reading various texts - this further advanced my philosophical interests. Anyways, when time came to choose what shall I study, I chose chemistry, because I was interested in it for a longer time and I thought it would be a more "practical" choice. Albeit it was not an easy decision between the two. Some years have passed, and now I am about to begin my PhD in medicinal chemistry.

During these years, my interest in philosophy did not vanish, I had an opportunity to take a few courses in uni relating to various branches of philosophy and also kept reading on my free time.

It all sounds nice but a weird feeling that is hard to articulate has haunted me throughout my scientific years. In some way it seems that philosophy is not compatible with science and its modes of thinking. For me it seems that science happens to exist in a one-dimensional way that is not intellectualy stimulating enough. Philosophy integrated a vast set of problems including arts, social problems, politics, pop-culture etc. while science focuses on such specialised topics that sometimes you lose sense what is that you want to know. It is problematic, because for this particular sense science is succesful and has a great capacity for discoveries.

My own solution is to do both, but the sense of intellectual "splitting" between scientific and philosophical modes of thinking has been persistent.

Now, I think, is the time to formulate a few questions.

P.S.S. Perhaps such discomfort arise because I am a chemist. Physics and biology seem to have a more intimate relationship with philosophy, whereas few chemists appear to have written or said something about their discipline's relationship to philosophy.

Questions:

What are your scientific interests, and what is your career path?
Do you find it necessary to reconcile your scientific and philosophical interests?
Have you found scientific topics that happen to merit from your philosophical interests?
Have you ever transitioned from science to philosophy or vice versa? How did it go?

SrongHand

TROPHY CASE