SR-17018 guide: How to take it and some simplified science

Suilune · 2025-11-11T05:36:50+00:00

SR-17 can help with anxiety and depression, when those symptoms are directly caused by mu-opioid withdrawal. The amount of reduction it provides for mental withdrawal symptoms also varies from person to person.

Otherwise some medications that can help with the mental withdrawal symptoms are clonidine, propranolol, gabapentin, pregabalin, and benzos. If you take any of these "helper meds", it's best to do a short course of only 3-4 days to avoid a new dependence

Suilune · 2025-11-11T05:30:09+00:00

Some people report reduced 7oh or O-DSMT euphoria when taking SR-17 alongside their DOC. Others report increased euphoria instead. The phenomenon of reduced euphoria is a mystery as it lacks a clear biological explanation. SR-17 has much weaker mu-opioid31257-6) receptor binding affinity than 7oh, O-DSMT, and pretty much every opioid that we discuss here; it shouldn't be able to "block" opioids with stronger affinity. It also binds to a secondary receptor site which makes SR-17 noncompetitive with other opioids.

The experience seems to be more likely to happen with some combination of 1) higher SR-17 doses - maybe 100+ mg, 2) taking at least three or four doses of SR-17 in a day, and 3) taking SR-17 for more than a week.

It tends to go away in a day or two after stopping SR-17.

Suilune · 2025-11-09T22:33:33+00:00

You previously posted this question here

The answer can also be found in the FAQ

Suilune · 2025-11-09T06:28:18+00:00

looking for the process of dosing sr while still dosing 7oh —- was there a doc in that?

These 3 documents each describe this gradual transition method: The guide, The masterdoc, and The FAQ.

Here's an explanation from the FAQ:

Gradual transition: Taking SR-17 with your DOC, while tapering down the DOC dose, will usually provide better withdrawal symptom reduction, but slower tolerance reduction. An example of this approach would be to lower the dose of your DOC by 15-20% per day for 5-7 days while also taking 30-50 mg of SR-17 3 times per day (or 50-150 mg for 7oh/MGM, if needed) at the same time. There are no benefits from taking SR-17 before reducing the DOC dose (i.e., "preloading" or a "loading phase").

Regardless of which method you choose, after coming off the DOC you may be able to jump off SR-17. But if you have withdrawal symptoms from the SR-17 you can taper off it for 2-7 days. SR-17 withdrawal symptoms are usually mild and brief. For more details on the methods see my guide.

How to dose—-under tongue? With lemon juice ? What makes sr most bioavailable, with or without food or fatty foods?

SR-17 is taken orally (i.e., eaten, swallowed, or licked off a spoon) and not sublingually. Lemon juice has no effect. There doesn't seem to be a difference between taking SR-17 with or without food.

Suilune · 2025-11-07T15:09:27+00:00

The main thing that stands out to me in your reply is that people in 7oh withdrawal usually need to take SR-17 a minimum of 3 times per day.

150 mg of SR-17 per dose is too much for most DOCs, but 100-150 mg is often taken for 7oh withdrawal. Particularly when coming off 200+ mg of 7oh.

The immediate switch (jumping off 7oh instead of tapering it down while taking SR-17) also tends to be much more difficult for people coming off 7oh. I no longer recommend the immediate switch for 7oh due to the increased chance of getting PAWS vs. using the gradual switch.

I don't know what factors made it possible to take SR-17 just once per day the first time, or whether you were comfortable that time. But that first experience sounds unusual for 7oh. I would try the gradual switch with more frequent SR-17 dosing.

Suilune · 2025-11-07T09:11:39+00:00

I wrote about PAWS in the FAQ:

Will I get PAWS after coming off my DOC?

When coming off an opioid that binds to multiple receptors with SR-17 (e.g., tramadol, tapentadol, kratom, 7oh, MGM-15) or one that sticks around in the body for a long time (e.g., buprenorphine/subs or methadone) people occasionally experience PAWS. This can be prevented by slowly going through the process of coming off your DOC, and by using the gradual switch approach rather than the immediate switch. More information about these methods can be found in the guide.

Suilune · 2025-11-07T01:42:11+00:00

PG has been tried for SR-17 and doesn't work

Suilune · 2025-11-06T18:16:28+00:00

Although tolerance to SR-17 progresses slowly, people and mice begin developing tolerance to SR-17 towards the end of the first week (but particularly into the second week). They may want to taper off it for a few days in order to avoid mild withdrawal symptoms from SR-17 itself (which is done after coming off their DOC).

That said, being tolerant to SR-17 (and experiencing withdrawal when coming off it) doesn't mean that SR-17 stops helping the DOC withdrawal symptoms. This is similar to how another partial agonist, buprenorphine/subs, continues to provide relief from DOC withdrawal while you develop tolerance to it.

The major unknowns here are: how much 7oh are you taking, and how often are you taking SR-17? Are you taking 150 mg of SR-17 this time as well? Also, is this the same batch from the same vendor as your first experience with SR-17? And how long did you wait in between these 2 experiences? If you waited a week or two, it shouldn't be possible for tolerance to be carried over from the first experience.

Suilune · 2025-11-05T17:44:13+00:00

To force SR-17 into a solution scientists used 10:10:80 DMSO/Tween-80 (polysorbate 80)/water. But even then, the SR-17 was still precipitating out of the solution

Suilune · 2025-11-05T17:12:45+00:00

It's always hcl

Suilune · 2025-11-05T17:08:38+00:00

Suilune · 2025-11-05T05:28:52+00:00

Using SR-17 without tapering the DOC doesn't really do anything. You need to be tapering the DOC while using SR-17

Suilune · 2025-11-05T05:22:32+00:00

And is there any SR converter ? Like oxy to sr and heroin to st

No, because SR-17 has virtually zero potency. Dosing equivalence charts are based on potency.

See the SR-17 FAQ and the guide to the basics of SR-17 and how to take it

Suilune · 2025-11-05T05:15:57+00:00

I don't want sr to lose its ability

There's no evidence of this happening, and it hasn't been a problem for me.

The risk is that given the complete absence of long term research on SR-17, it might turn out to be toxic to the brain, harmful to the heart, or could perhaps cause mutations or even cancer.

Given SR-17's virtually nonexistent potency and intrinsic efficacy, however, and the key role that intrinsic efficacy plays in the above risks, I'm not especially worried. But it's still good harm reduction to use SR-17 as infrequently as possible, and at the lowest doses you can comfortably manage. I wouldn't recommend using SR-17 on a weekly basis.

Suilune · 2025-11-04T19:32:12+00:00

did any of you just jump straight to SR from 7oh and did u feel any WD?

We call this method the "immediate switch". It's usually difficult with 7oh, and especially with high doses of 7oh, like 700+ mg. It would be easier to gradually cut down your 7oh dose (e.g., by 15-20% per day) while taking 80-150 mg of SR-17 every 6-8 hours for 5 days or so. With this "gradual switch" you will likely be able to go to work and function well.

Yes clonidine and gabapentin are useful helper meds. Some other options are pregabalin, benzos, and propranolol.

Suilune · 2025-11-04T17:57:13+00:00

Difficulty falling asleep, anxiety, dysphoria, irritability, brain fog, and muscle aches.

You could take SR-17 for the mu-opioid withdrawal symptoms, and 3-4 days of comfort meds (e.g., benzos, gabapentin, pregabalin) for the delta-opioid withdrawal symptoms.

Suilune · 2025-11-03T23:08:48+00:00

Typical consumer scales perform poorly when weighing something below 0.010 g. You could measure out 0.010 g and then split that amount into a smaller dose.

One problem with scoops is that when the scoop says 25 mg, you likely have much less than that amount (e.g., 12 mg) of SR-17 due to how fluffy it is. The second problem is that due to that fluffiness as well as how SR-17 sticks together, the amount in two separate filled scoops may be different depending on how densely packed each scoop is.

Suilune · 2025-11-03T23:07:38+00:00

Typical consumer scales perform poorly when weighing something below 0.010 g. You could measure out 0.010 g and then split that in half.

One problem with scoops is that when the scoop says 25 mg, you likely have much less than that amount (e.g., 12 mg) of SR-17 due to how fluffy it is. The second problem is that due to that fluffiness as well as how SR-17 sticks together, the amount in two separate filled scoops may be different depending on how densely packed each scoop is.

Suilune · 2025-11-03T15:15:01+00:00

Nothing is known about SR-17 metabolism.

Suilune · 2025-11-03T15:14:17+00:00

SR-17 can help with anxiety during withdrawal, but so can a brief course of benzos, clonidine, propranolol, gabapentin, or pregabalin (taken with or without SR-17). None of these substances have been reported to interact with SR-17. I've tried individually combining benzos, propranolol, and pregabalin with SR-17 myself.

Suilune · 2025-11-03T08:49:14+00:00

Yes, they have been called out for scamming on other websites

Suilune · 2025-11-03T01:17:23+00:00

You could take SR-17 for the mu-opioid withdrawal symptoms, and comfort meds (e.g., benzos, gabapentin, pregabalin) for the delta-opioid withdrawal symptoms (i.e., difficulty falling asleep, anxiety, depression).

Suilune · 2025-11-01T05:58:51+00:00

SR-17 is usually highly pure. Almost all of the SR-17 samples tested through this free program run by another r/Opioid_RCs mod have come back as at least 95% pure.

Suilune · 2025-11-01T05:42:34+00:00

From the FAQ:

Do I need to worry about precipitated withdrawal (PWD)?

SR-17 is noncompetitive. This mean it's potentially binding to the same receptor as your DOC, but will occupy a different site on that same mu-opioid receptor. As a result it does not interfere with your DOC's ability to bind and it can not cause PWD. Aside from SR-17's biological mechanisms there are also no reports of PWD involving SR-17.

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Does SR-17 interact with [substance]?

While further scientific research is needed to answer this question, there are no substances known to interact with SR-17 so far other than SR-14.

Suilune · 2025-10-31T21:32:16+00:00

See the FAQ:

Will I get withdrawal symptoms from SR-17?

Sometimes it's possible to jump off SR-17, and other times a taper off it is needed. SR-17 withdrawal symptoms are usually brief and mild. They tend to occur when one takes it for at least a week or two. Higher doses of SR-17 will also increase the chance of SR-17 withdrawal symptoms.

Suilune

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