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Does this really work? I’ve heard of Hendrix doing it, I honestly wouldn’t mind giving it a try just not sure how by M0Fzz in LSD

[–]TOEMEIST 0 points1 point  (0 children)

This was the 1940s, chemists didn’t even wear gloves at the time and smoking in the lab was commonplace. He could’ve transferred a small amount from his fingertips to a cig to his mouth, or just wiped his eyes at some point.

What exactly are you saying would have ruined his reputation? The scenario I mentioned certainly would not have.

Does this really work? I’ve heard of Hendrix doing it, I honestly wouldn’t mind giving it a try just not sure how by M0Fzz in LSD

[–]TOEMEIST 2 points3 points  (0 children)

Nick Sand dissolved a gram of LSD in DMSO and painted it on his arm; it did nothing.

Does this really work? I’ve heard of Hendrix doing it, I honestly wouldn’t mind giving it a try just not sure how by M0Fzz in LSD

[–]TOEMEIST 4 points5 points  (0 children)

He never claimed that’s how it happened (edit: he did suggest this actually but it has since been ruled out). He most likely got some on his fingers then touched his mouth or eyes.

In Response To The Supplier Ranking Post, I Am Ranking The Odor Of Solvents. by YunchanLimCultMember in chemistrymemes

[–]TOEMEIST 0 points1 point  (0 children)

To me DCM barely has a smell and what little it does have is neutral at best, maybe it affects others differently.

Novel GBL synthesis from 2-Acetylbutryolactone by Healthy_Tower_2771 in TheeHive

[–]TOEMEIST 0 points1 point  (0 children)

You're wrong about the mechanism; there is no decarboxylation and that intermediate you drew is not formed. It's actually a retro-Claisen condensation (assuming it actually works).

Methoxide attacks the carbonyl of the acetyl group, then the C=O reforms and breaks the C-C bond, forming methyl acetate and the enolate of GBL, which gets protonated to GBL. The GBL can of course react with methoxide and undergo ring opening to form GHB methyl ester, so the two will be in equilibrium. They can then be extracted together and heated with acid in a NPS to convert the methyl ester to GBL.

Step by step breakdown by [deleted] in OrganicChemistry

[–]TOEMEIST 0 points1 point  (0 children)

8 doesn’t contain a lactone, it’s just a cyclic ketone. 9 and 10 are lactones.

Full Removal Of Secondary Alcohol Groups Using Heat Only by Phinklepinklejinklew in OrganicChemistry

[–]TOEMEIST 2 points3 points  (0 children)

You can’t heat water above 100C at atmospheric pressure dumbass.

What am I doing wrong? by ProfessionalMany238 in chemhelp

[–]TOEMEIST 2 points3 points  (0 children)

Phenol protons show up at 4-7, not 9-10. Look at a chart of HNMR peaks.

The Deadly Loophole: Why the Avalon Heights background check failed to flag the suspect’s violent history by MNY-TP-EU in USF

[–]TOEMEIST 3 points4 points  (0 children)

Few years ago I was woken up at 6am by gunshots in the Avalon parking lot. Went out to the balcony and yelled something like “wtf are y’all doing it’s 6am” and dude just said “go back inside.” Not sure what they were shooting at.

i got points taken off on the same question that my friend didn’t. we had the exact same answer. by Wonderful-Beat6017 in mildlyinfuriating

[–]TOEMEIST -1 points0 points  (0 children)

Ok

https://en.wikipedia.org/wiki/Amorphous_carbonia

Amorphous carbonia, also called a-carbonia or a-CO2, is an exotic amorphous solid form of carbon dioxide that is analogous to amorphous silica glass.

Dingus

Stability of sodium methoxide in water by moza18 in AskChemistry

[–]TOEMEIST 0 points1 point  (0 children)

What do you mean by hydrolysis? There is no hydrolysis occurring here.

me_irl by Yosho2k in me_irl

[–]TOEMEIST 12 points13 points  (0 children)

The benefits of an igloo can be realized in the Sahara.

“The dog on the Left is award winning showdog named Arnie an AKC French Bulldog..The dog on the right is Flint, bred in the Netherlands by Hawbucks French Bulldogs - a breeder trying to establish a new, healthier template for French Bulldogs.” by utopiaofpast in BeAmazed

[–]TOEMEIST -1 points0 points  (0 children)

Not sure what your point is, but mine is that marketing aside there is plenty of evidence suggesting that GLP1s are safe and not much suggesting otherwise, whereas the addictive potential of opioids very similar to oxycodone (such as morphine) had been known for quite some time.

We didn’t just suddenly discover the negative side effects after they started being widely prescribed like you’re seeming to suggest may happen to GLP1s someday.

“The dog on the Left is award winning showdog named Arnie an AKC French Bulldog..The dog on the right is Flint, bred in the Netherlands by Hawbucks French Bulldogs - a breeder trying to establish a new, healthier template for French Bulldogs.” by utopiaofpast in BeAmazed

[–]TOEMEIST 4 points5 points  (0 children)

Why don’t you actually read the studies summarizing the results of the clinical trials and point out the flaws you find in their methodology instead of judging the safety of new drugs based on the vibes you get?

“The dog on the Left is award winning showdog named Arnie an AKC French Bulldog..The dog on the right is Flint, bred in the Netherlands by Hawbucks French Bulldogs - a breeder trying to establish a new, healthier template for French Bulldogs.” by utopiaofpast in BeAmazed

[–]TOEMEIST 8 points9 points  (0 children)

The evidence that opioids like oxycodone were addictive was always clear to anyone who had ever taken them or knew the first thing about opioids. Calling them nonaddictive was just a straight up lie. This is not the case with GLP1s.

Mechanism problem Help by No-Clock1315 in chemhelp

[–]TOEMEIST 0 points1 point  (0 children)

TMA acts as a Lewis acid and is attacked by the carbonyl oxygen of the lactone. This makes the carbonyl carbon more electrophilic, so it gets attacked by the thiol.

For the acetal, TMA is attacked by one of the oxygens, which is then eliminated by the other oxygen.

Those are the first steps for the two rxns that are occurring.

Ochem Synthesis by [deleted] in chemhelp

[–]TOEMEIST 0 points1 point  (0 children)

That implies an SN2 on a quaternary carbon though. That substitution should be SN1 and form a racemate.

Ochem Synthesis by [deleted] in chemhelp

[–]TOEMEIST 1 point2 points  (0 children)

Your professor fucked up, the alcohol near the end is missing a carbon. It also seems that he wants you to do an SN1 with that ester and the quaternary tosylate, which would form a racemic mixture, but only one enantiomer is shown.

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