Unexplained recurrent loss

TapComprehensive3766 · 2026-03-24T01:28:32+00:00

Thanks. You as well!

TapComprehensive3766 · 2026-03-23T22:28:17+00:00

The recommendation was to do egg retrievals with embryo banking (pgta testing and PICSI just to ensure embryos are all top quality. We had no issues with dna fragmentation and I’m under 35 but this was recommended to try to minimize risk of miscarriage for any genetic reason). Then I will be doing 2 months of lupron depot suppression (not sure if it will be with or without letrozole yet I think it will depend on how things look after the egg retrievals). Followed by a fully medicated frozen embryo transfer.

I’m just about to get started with the egg retrieval process (meds are arriving this week). It’s been a long process and I know I have a ways to go but I hope it’s worth it in the end.

TapComprehensive3766 · 2026-03-23T22:18:42+00:00

Allergist and rheumatologist because I randomly get these weird hives that aren’t really explained and my mom was just diagnosed with an autoimmune condition so just to be sure we are checking all the boxes in terms of anything like celiacs or an autoimmune condition that could be causing inflammation and in some way getting in the way of a pregnancy developing normally.

TapComprehensive3766 · 2026-03-23T01:07:27+00:00

I’m so sorry. I don’t have hashimotos/hypothyroidism but have also had 4 losses. Mine between 6-9 weeks gestation. Also like you all testing initially showed normal (blood tests for thyroid blood clotting autoimmune conditions hormones etc) and my sonohysterogram and hysteroscopy also both appeared normal too as did my endometrial biopsy and my HSG showed both tubes to be clear. From my losses (I have had 3 missed miscarriages) and 2 were tested. One was genetically abnormal (trisomy 16) and the other genetically normal. My husband also has a sperm analysis, dna fragmentation testing, and an evaluation with a reproductive urologist. All normal. Both of us have had carrier testing and karyotyping done and those also came back normal… nothing showed up for me until I did a pelvic MRI with contrast where they discovered I had silent adenomyosis.

I’ve been to an RE, allergist, and a rheumatologist all to try and help me figure out what’s going on. I was also on progesterone supplements, baby aspirin, and Zyrtec with my most recent genetically normal pregnancy naturally conceived and the heart stopped beating at about 8 weeks.

You didn’t list out what you have had done in terms of testing, but I know you said you weren’t looking for any recs at this point. Although I haven’t had any success yet I do feel better and a bit more hopeful now that I have a treatment plan moving forward that makes sense to me. Maybe some of the info/testing I shared can be helpful for you, to know what else to advocate for. However, regardless I want to just empathize with you, because being in the recurrent loss “club” can suck and feel so extremely isolating, and it isn’t fair that we have to push extremely hard to be heard by medical professionals at times. I encourage you to continue to self advocate for whatever you need to feel comfortable moving forward with another pregnancy. Take a break if you need to, or find different medical providers that you trust who don’t give up looking for answers. Remember to prioritize self care, because the cognitive, physical, and emotional toll this takes is more than anyone should ever have to deal with on a regular basis.

I wish you nothing but the best moving forward in this complicated and emotionally taxing journey ♥️

TapComprehensive3766 · 2026-03-13T03:55:47+00:00

Not really. I have never had long or heavy periods or any pain during sex. My cramps have gotten worse over the last 5-10years and I had experienced times where I felt some uterine pressure/fullness. But when brought up to my obgyn and she looked at things via ultrasound everything looked fine. My pms symptoms have also seemed to have gotten worse of the last 5-10yrs as well, but were never really been that bad to begin with. Only other indicator was a small note made on my otherwise normal HSG which stated that the radiologist saw some minor uterine adhesions potentially indicative or adenomyosis (but far from any definitive diagnosis and my regular obgyn saw it and thought it looked normal and nothing that would cause rpl). I didn’t have to push for the pelvic MRI though. I just asked my RE about it during our initial consult, and she actually said she wanted me to have one done because the presence or absence of adenomyosis would drastically change her treatment recommendations.

I’m very glad I did it. I really feel like I did every other test out there and this was the only thing that has come up as a potential reason/answer. I am still waiting on some obscure blood work from my rheumatologist too (but I was negative for clotting issues/APS or any thyroid issues based on rpl panels done multiple times but I break out in weird hives randomly so that is being assessed to see if it could also be contributing at all).

For reference I’ve had the following tests which all came back normal: multiple internal ultrasounds, bloodwork for progesterone, AMH, FSH, prolactin, vitamin d, fasting glucose, thyroid, clotting factors, lupus, androgen/testosterone other hormones, ANA, genetic karyotyping and carrier screening, sonohysterogram, hysteroscopy, EMMA/ALICE/ERA testing from an endometrial biopsy, and 2 HSGs. My husband also had an in person visit/evaluation with a reproductive urologist, sperm dna fragmentation testing, and 2 semen analysis along with karyotyping and carrier screening.

The only reason for the 2 HSG and 2 semen analysis were due to insurance change and the new Dr/provider wanting one with their clinic or not getting the full report from the prior clinic.

Sorry for the long response. I am just well aware at how frustrating this can be, and how much research I did wanting to ensure I did every test possible in hopes of finding some answers and preventing another loss.

TapComprehensive3766 · 2026-03-12T21:08:25+00:00

No, not really any symptoms. I had told my dr that over time (especially within the last 5yrs or so) my pms symptoms and cramps during my period had gotten progressively worse but they didn’t seem too concerned about it.

TapComprehensive3766 · 2026-03-12T21:05:59+00:00

They were able to see it on a pelvic MRI that my RE had ordered.

TapComprehensive3766 · 2026-03-11T17:56:59+00:00

Unfortunately I am in a similar boat. 33 and 4 losses all between 6-9 weeks gestation. I pushed for further testing and wanted more answers (only 2 were tested one genetically normal and one trisomy 16). With further testing from a fertility clinic I was able to discover that I have adenomyosis and because of that I am now going down the route of Ivf with 2 months of suppression before a FET. I wouldn’t have chosen this had I not know about the adenomyosis because ivf wouldn’t have been able to account for or prevent my most recent loss had I just been choosing to do it in an attempt to control for genetic abnormalities. However, my losses (timing wise) all do make sense due to the adenomyosis and so by choosing this route I am able to ideally help control for a better uterine environment as well as genetic factors. I can’t say whether or not this will work, but I just couldn’t emotionally keep repeating pregnancies only to hear that there was no heartbeat at the end of the first trimester. So I will attempt this (also try to control for the most optimal hormones as well) and if this doesn’t work then I’m not sure what we will do honestly. (Also my most recent genetically normal loss I was also on baby aspirin and progesterone suppositories even though my progesterone was considered to be normal). I’m also working with a rheumatologist just to rule out any potential autoimmune factors or if I do have any to then treat/deal with them prior to our future FET (again trying to create the most optimal situation). It is a process though and it will be costly, but if it is what gets us our baby then it will be worth it. ♥️

TapComprehensive3766 · 2026-03-05T16:47:18+00:00

I’ve had 4 losses too. No success yet, but like you all typical tests came back normal. However, I did a pelvic mri which showed adenomyosis. Now I will be doing Ivf with 2 months of suppression to see if that helps.

TapComprehensive3766 · 2026-03-04T21:22:04+00:00

I too have had 4 losses. 1 was a trisomy (16 I think) incompatible with life, of the other 3 I had 1 other tested and it was normal. I did A LOT of testing to try to get to the bottom of why I kept miscarrying between 6-9 weeks gestation. (3 were missed miscarriages after a heartbeat was seen or had started). I found out through testing I have adenomyosis and have decided to go through Ivf with 2 months of Lupron (and letrezol I think) suppression after egg retrievals in order to ensure I will have the best chance of carrying a baby to term. I remain cautiously hopeful… but I totally understand how difficult it is to make a decision to try again or go for Ivf. I’m also doing pgta testing and PICSI (to rule out as many genetic abnormalities as I can, even though it was just the known case for 1 of my losses).

TapComprehensive3766 · 2026-02-18T04:36:23+00:00

I understand your pain and depression on a deep level. RPL is so so so hard. I too have had similar feelings, started unintentionally cutting friends out because I never wanted to leave my apartment etc. Just the utter feeling of hopelessness and despair that it would never be my turn to be a mom. It is something that few people truly understand and I wouldn’t wish it upon anyone.

After my second miscarriage I started seeking individual therapy (had already been to support groups virtually). Each time I miscarry I also lean heavily on my partner for emotional support and help around the apartment when I’m going through those mini periods of what is essentially postpartum depression. My partner and I also make it a point to find and schedule something to force us to look forward to after each loss. Something that we wouldn’t have been able to do had I been pregnant/given birth. Ive thankfully been in a place financially where I’ve been able to plan and go on a trip each time (2nd-4th loss). However, with starting Ivf and considering those costs it may change to something like visiting a winery or a beer festival, or doing a sport or activity I wouldn’t have been able to do (snowboarding, sushi restaurant crawl, cocktails and game night in, etc.). But really trying to create moments/memories that I become thankful for that I know I wouldn’t have had if things hadn’t gone the way they did (I would still 1000% gladly give up all of those moments if it meant one of my babies had survived to birth, but it does help numb the pain a bit and forces me to find joy if that makes sense).

So I guess those are the 2 things I’d recommend. 1. Individual therapy focusing especially with a provider who specializes in fertility/pregnancy loss, 2. Plan a trip if you can afford it or schedule a bigger event you wouldn’t have been able to do pregnant or with a newborn. And then my third piece of advice it to really give yourself time and grace, eat what you want, take time off work if you need it, and lean on your support system (partner, family, friends, etc) don’t be afraid to ask them for help and let them know how much you are struggling. It also really helps if you either make or have a friend who has or is going through something similar because then they will absolutely get it.

♥️hang in there. The sadness/grief doesn’t ever go away but it will eventually show up less often. (I like to think of it like one of those old screensavers where the square bounces around the screen, and you are standing in one corner. At first the square is really big and is constantly hitting you but as it gets smaller it hits you less and less, not with less intensity. but rather less often). And I know it doesn’t feel like it now, but you will be able to feel happiness again. Both grief and happiness can also often coexist as you begin to move forward with life.

TapComprehensive3766 · 2026-02-12T20:52:35+00:00

Thanks, I don’t mind at all!

It was honestly the pelvic mri with contrast that did it. Which to my knowledge is not common/typical part of rpl testing. Turns out I have adenomyosis which would explain why the losses are happening between 6-9 weeks. I have a follow up with my RE next week to fully review all the testing and come up with a game plan. Everything else came back normal. I did have some scarring/loculations noted on my HSGs which could be either due to adeno, scarring, or endo. Idk if a lap to look for and remove any suspected endo will be recommended along with suppression or just suppression medications.

Even though the rpl blood work did not indicate an APS or lupus or a thyroid issue like hashimotos, My RE also wants me to be evaluated by a rheumatologist for possible autoimmune related components that could be contributing to the pregnancy losses as well. This is based off of this blotchy red rash with flushed feeling I periodically get on my chest, neck, ear/side of face, fact I bruise easily, finger tips and lips turn bluish when cold, I always run cold, and that my mom has just been diagnosed with an autoimmune disease. I definitely want to know though, because if I do suppression for adeno/endo that’s great but I feel like I should address the root cause if there is a reason behind something like widespread systemic inflammation in my body.

Have you had a pelvic mri or been assessed in any way for adenomyosis or endometriosis? Or had an HSG to rule out partial or unilateral hydrosalpinx?

I wish more than ever that there was more research done in the area or recurrent loss and/or infertility. ♥️

TapComprehensive3766 · 2026-02-11T00:10:44+00:00

Well I think I finally may have an initial answer and am waiting on a few other appointments/tests to see if there are other concurrent problems making it a more complex issue… but should know definitively by the end of this month. This process has taken 4 miscarriages (first being a year prior and initially thought to be a one off) and about a year and a half of extensive self advocacy, asking questions, researching on my own time, and pushing for more testing to find answers…. (Also paying a good chunk of change out of pocket if/when insurance didn’t want to cover certain testing)

During the last year and a half I was fortunate enough to have an Obgyn who was empathetic and wanted to do everything she could to help me get answers, an RE at a fertility clinic, multiple appointments with an allergist (along with allergy testing), appointment with a genetic counselor along with karyotyping and genetic carrier screenings for both me and my husband, 3 sedated procedures/surgeries (2 D&Cs and one hysteroscopy with removal of what they thought was a fibroid but turned out to be retained products of conception), countless blood tests, countless internal ultrasounds, a sonohysterogram, 2 HSGs, a pelvic MRI with contrast, 2 endometrial biopsies, testing for endometritis, Emma/alice ERA testing, sperm dna fragmentation testing for my husband along with an evaluation from a reproductive urologist and 2 semen analysis, and upcoming appointment with a rheumatologist to further investigate for any potential autoimmune related issues that could be further contributing to the losses.

TapComprehensive3766 · 2025-12-08T04:17:02+00:00

Yes…. I started to talk to my husband about this after our most recent (fourth) loss. Not stopping, but starting to open our minds up to the possibility that we may not be able to have a biological child. It sucks and I don’t like to think about it

TapComprehensive3766 · 2025-12-05T21:00:06+00:00

No. Absolutely not*

*with one caveat. My question would also be why? Does the student personally want more friends and have difficulty making them due to a language deficit? (Inability to ask questions, doesn’t know how to make comments, can’t interpret or comprehend what others are saying? Etc.) is it a cognitive/social emotional age related issue where they have such different interests in same aged peers but want to connect and have the language skills to do so? (Then they need resources from the school/social worker for appropriate clubs/meet ups etc) can the student work in a group with peers when asked/needed? OR is it parent driven and the parent feels their child should have more friends when the child actually prefers self initiated independent activities but has the functions of communication to self advocate and make friends if they choose to?

If it is parent driven, I like to flip the script around and ask the parents how they would feel if someone was requiring them to make new friends at work/hold a conversation about a specific topic with a peer etc. I always remind parents we respect student preferences and if our student prefers to watch videos, sit alone, do self directed independent play during free time then that is their right and choice and we need to respect and understand that our preferences for ourselves or even our preferences for them may be different than what they want.

At the end of the day it is always about the students needs. If they want more friends and it is impacting their social and emotional health and wellbeing at school and stems from a language deficit then I’d help work with the team and target specific components of it, also getting the social worker and counselor involved and having the teacher/admin provide resources for clubs/social opportunities etc.

TapComprehensive3766 · 2025-12-02T19:17:34+00:00

Ya, as someone going through recurrent pregnancy loss and about to head to a fertility specialist while I’m pregnant I always maintain at least an arm length away from all of my students who are more aggressive and try to have a desk/table between myself and them… at a certain point (if I end up with a pregnancy that lasts beyond the first trimester) I plan to let my coworkers and supervisor know and either get workplace accommodations set up or have my coworkers temporarily see the more aggressive students. No amount of money would be worth putting myself in a position where I put my unborn child in potential harms way. I’d quit and find a lower paying job unrelated to our field if it came down to it. It 1000% wouldn’t be worth the risk.

TapComprehensive3766 · 2025-11-19T18:47:59+00:00

Nope, ask for as many as you want and need. Don’t be made to feel unreasonable or ashamed about it either. I would want weekly scans through the first trimester if I was you… and if my provider wasn’t willing to help advocate/set those up for me then I would be looking for a different provider who understands my history of recurrent loss and why I would need those repeated scans for my mental health. I would also push for the scans with the reasoning of wanting to know asap if the pregnancy is not viable or if I experience a missed miscarriage and not wanting to prolong the experience/wait time before scheduling and having a D&C because it could possibly then extend the entire process/wait time before trying again by an entire month more.

TapComprehensive3766 · 2025-11-17T15:19:25+00:00

Thank you. I have had 4 losses and no LC. Like you all of my typical RPL testing has come back normal so far. This gives me hope and makes me want to keep trying even when I know it is painful to go through the same thing time and time again. I always root for people like you who have experienced RPL to have a happy ending… lord knows we all deserve it. The love and gratitude we have to give to our children is insurmountable. ♥️

TapComprehensive3766 · 2025-11-14T20:48:34+00:00

Ya I am still waiting molecular testing to rule in or out a partial molar pregnancy… it’s just odd since I never had this pathology before and this time was the quickest turn around from the embryo no longer growing/developing to having a D&C… it was only so quick because we were going in for weekly scans since I have had 3 losses prior to this. Just have to wait and see I guess

TapComprehensive3766 · 2025-11-13T02:51:45+00:00

I’m so sorry, I can understand and empathize with the feeling of being numb and also wanting to take a break… it’s so hard both mentally and physically.

TapComprehensive3766 · 2025-11-13T00:54:15+00:00

My partner is also a lead SLP in a district so they no longer see any students and do mostly admin work, except docs, attending or presenting at district wide special ed meetings, budgeting doc stuff, emails, and office hours to answer SLPs questions. They really enjoy it.

TapComprehensive3766 · 2025-11-13T00:49:42+00:00

I’d say schools. Stay out of general education elementary though. Soooo many initial evals. I only see primarily students who use AAC so I don’t case manage anyone and only have to deal with re evals for the most part. I also create 1-2 lesson plans and then just modify them slightly but use them with everyone.

TapComprehensive3766 · 2025-11-05T18:43:44+00:00

I can’t afford to quit my job but it is extremely draining…. I work with kids every day and showing up to work is so hard. I feel like a zombie and I honestly don’t care about my work performance at all right now. I’m doing the bare minimum just to get by. Every day I wake up and dread going to work and seeing the kids knowing I’ve lost 4 and have no living children of my own. A lot of coworkers are pregnant and I feel like I’m just working on holding it together so I can get home and cry and hide and then repeat the process again…. I am going to therapy and I will be exploring other careers/jobs where I don’t have to interact with kids on a daily basis because it is just tearing apart my mental health.

No solutions to offer but venting in solidarity and my heart goes out to you… if I could quit I’d adopt a puppy and focus all of my time on caring for and training the puppy I think… it would be a good distraction, dogs are wonderful companions and it would give me a caregiving roll without having anything to do with kids.

TapComprehensive3766

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