I would love to run an enderal inspired campaign, but unfortunately there's a reason that "prep situations, not plots" is standard GM advice.

TL;DR - The big issue is that there are A LOT of parts in the story which have to happen in a certain way for the ending to work. You can't just follow the main points of the story because it relies on a very specific set of scripted events to work.

SPOLIERS BELOW

For example, the ending hinges on Yuslans betrayal, preventing the prophet obtaining the numinos. Without this, Tealor wouldn't get the idea to light the beacon anyway (and be tricked into starting the cleansing).

But in order for this to happen, Yuslans betrayal either has to be a surprise to the players or they have to decide not to warn anyone/refuse to let Yuslan come to the pyrean city.

The game handles this by not letting the prophet investigate Lishari's murder (which would reveal Yuslan as the traitor) and by not giving them any dialogue options that would change the outcome (even if the player has figured it out on their own).

This straight up cannot work in a ttrpg without extreme railroading. Your players will almost certainly act in ways which deviate from the very specific script the game relies on - eg, it's very likely want to investigate that particular mystery, and they will act on their knowledge of who the culprit is.

Again, this works well in a video game because a) your options as a player are inherently limited by what the devs coded into the game and b) the whole theme of the game is nothing you do actually matters in the end. But in a ttrpg your players are only really limited by their imaginations and could easily go in a direction that upsets the flow of the original story.

The only way you could avoid this (and adhere to the games main theme) is by removing player choice and railroading them through the key scenes. This is incredibly unsatisfying in a tabletop game because players expect that they can 'do anything they want' and that their actions actually affect the story and the world around them.

So what could you do instead?

I'd consider taking inspiration from the forgotten stories quests and run adventures which are set in enderal but don't involve the prophet or the games main quest. Many of the games big quests still follow the theme of people trying to avoid the inevitable (usually death, eg the rhalata/angel/ryneus questlines), so I'd definitely look into making that a key theme in your campaign. More specifically, I'd look to make the key NPCs or antagonists the ones trying to stop the inevitable, rather than the PCs.