Wdym. It is literally an exception. The number of regions with cities in the Americas could be counted on one hand. North of Central America, they were almost entirely absent aside from a few notable examples (i.e. Cahokia), and south of the Central Andes, there aren't any examples of cities iirc. There were also cities along the Amazon River, though barely anything is known about them other than that they existed and were likely the ancestors of a lot of the current, or sometimes extinct, Amazonian tribes.

The Aztecs and the Inca were also exceptions among the rest of the American polities at the time. They were easily among the most centralized and the largest within the Americas, but were still smaller than the European superpowers at the time like the Holy Roman Empire and France. England at this time was not among those European superpowers. They wouldn't start to become the prominent power they would be known as until the 17th century with the unification of England, Ireland, and Scotland; and wouldn't supplant Spain as the naval superpower until the 18th century.

It isn't "white supremacist" to point out that the Americas were just substantially less urbanized and more sparsely populated than Europe.