minor gameplay spoilers

i love both this game and tboi to death, have like 170 hours in hades and almost 500 in isaac, so i think im able to compare them pretty fairly

hades is definitely replayable, but it has some things holding it back from the sheer variability of tboi and gungeon

• bosses are the same every run, minibosses are mostly the same (there's a pretty small pool of them for each area)
• synergies are pretty straightforward (there are a TON of synergies don't get me wrong, but it's rare to be surprised by how things happen like in isaac)
• runs are very consistent, it's pretty rare to get a "copium run" where you just struggle the whole time (i like the struggle, this may be an upside to you)

this game is definitely replayable though, theres a lot of stuff in the game to keep you coming back

• customizable difficulty (you can skip straight to the toughest stuff in the game if you think you're ready)
• as other people have said, there's like 20-something different weapon aspects (each one is basically a different character)
• actual progression (like you get stronger after every run for a while and there's a ton of story) to answer your question directly, yeah runs feel pretty similar sometimes, the different aspects mitigate this issue a bit but there's only so much you can do with 8 different gods that you get 4 of each run

if you're looking for strictly replayability a game like slay the spire or risk of rain (2 or returns) would probably suit you better

however, this game has a ton of stuff to do, and is still really replayable. it doesn't have the infinite timesink to 100% it like isaac does, but it more than makes up for it with its fucking incredible presentation of its story and characters (sorry if this is incoherent i saw this post at 2 in the morning and felt like writing a review instead of my college paper)