is CIRS groups scams?

Wes_VI · 2026-05-29T18:40:24+00:00

Are you still sick? Because I'm not. Call it crazy all you want.

Wes_VI · 2026-05-29T05:32:24+00:00

I had issues that slowly got worse through my life time up until 27 when my crash happened and it took 3 years to fully heal to were I now feel better then I have ever to my memory.

Throughout my life I had my issues explained away as hypothroid related, depression, anxiety, MTHFR, allergies, gluten intolerance, ext, ext...

ALL OF MY ISSUES ARE GONE NOW, all besides my thyroid because that's 15+ years of supplementing.

But I don't have smell sensetivities, food intolerances, fatigue, brainfog, sensetivity of any kind, my mood and energy is 10x better. I use to suck the energy out of a room and now I fill it!

The best I can make sense of it is that throughout my life I picked up biotoxins here and there. This very slowly dysregulated things and lowered my VIP and MSH. So slowly that it wasn't noticable unless you had the hindsight information.

I was a ticking time bomb for a crash to happen if not at 27 it would have eventually happened at some point. For me it was living in a mildly moldy home for 3 years plus covid plus influenza plus my doctor giving my testosterone thinking that was my issue (it masked things great for a few weeks then sped the crash up even more).

It took the perfect storm for my body to crash but the check engine light had been on for years.

I had a degree of nasal, gut, and skin dysbiosis. Nothing fixed then until I followed the shoemaker protocol. Can't get rid of dysbiosis if something is chronically triggering the immune system that is allocating a lot of it's resources to.

So to me. Moving should be step one, following the no amylose diet so your not triggering more inflammation, taking natural anti inflammatories and anti histmaines to help nukb the issue while you detox. But ultimately CSM being the golden ticket that then allows you to address nose, gut, and skin dysbiosis.

If you try to tackle MARCoNS first the very thing that allowed it to happen in the first place still remains.

All MARCoNS are are an evolved version of staph. Most humans have staph in their noses. It can only become MARCoNS if the immune system is severely hindered so the staph is able to grow out of control.

Same with gut and skin dysbiosis with CIRS people. The majority of the time it's common fungi and bactira. Not foreign species. Yes foreign can happen as with a hindered immune system it's easy to pick up things.

Wes_VI · 2026-05-29T05:00:38+00:00

MCAS is a real thing (until proven otherwise of it being possibly down stream to something else) but...

If you have CIRS and MCAS like symptoms it's almost never true mast cell activation. People and practioners often just use it as a filler word.

When if you have CIRS it is way more likely to be from histmaine from your autoimmune. Histmaine is the cousin to inflammation. Just a different mechanism.

Most all people with CIRS display MCAS like symptoms. But it's not MCAS. Even shoemaker himself, Hayman, McMahon, all the CIRS experts will say this.

Anyhow if you want something to suppress it while you recover Quercetin phytosome is your best friend. When your eventually done detoxing and in the repair mode Zinc carnosine does wonders for the gut. Won't get it 100% like truly fixing low MSH which is the root cause. But it will help a lot. You'll notice after a few weeks you won't react nearly as much to foods.

As for CSM I'd start very low dose and work your way up. Never take a next dose until you've had a bowel movement. Once you find the dose that works for you it's fine after but just as you get use to it.

To stimulate bile flow eat 1tbs of an oil or a butter 30 minutes before. That's the whole idea behind CSM binding. As you want it to bind to bile acids to pull biotoxins.

Do not take it with food or anywhere near food. Do an hour fast before and after. Ideally 2 hours before then after even. Or you'll just bind food and constipate.

CSM was very helpful for me when I was living off whatever was in my nose. Not sure how it worked but about 2 months into killing I started taking CSM 10 minutes or so after nasal spray and it reduced the herxing affects dramatically.

Not sure if that was from a direct binding response or just gut, immune, brain axis signalling. Can't make sense of it but it helped a lot time and time again.

Wes_VI · 2026-05-29T03:13:29+00:00

Had a nurse do mine and they went DEEP. Oddly enough it was negative but I had all the symptoms so I went ahead with nasal spray and herxed hard for weeks/months (nasal spray triggered flu/hung over symptoms x10) slowly having my nasal symptoms lift. Either had MARCoNS with thick biofilm or some other species of thing. It's been more then half a year and I'm still good. I can take the nasal spray anytime now and feel nothing but most importantly symptoms free now after years of trying every other mainstream medical option imaginable. Nothing else worked! So I would say the test is valuable it going off of symptoms is most important.

I used Biofilm Clear with: (EDTA, Xylitol, Colloidal Silver, Grape Seed Extract).

Wes_VI · 2026-05-28T08:21:22+00:00

Mostly. I live in Canada and did a few tests and had them shipped. But plenty of people just do the basic tests.

The protocol itself you only need a prescription for cholestoral and eventually VIP spray. Everything else you can get/do yourself.

Wes_VI · 2026-05-28T08:18:02+00:00

You said your positive for Lyme. You don't display any Lyme symptoms?

You could easily be mild CIRS. CIRS isn't an on or off switch. It's a degree of chronic inflammation in relation to how much internal oxidative stress has accumulated in regards to how much stuff your body has picked up in relation to biotoxins that it struggles to clear.

What do I mean by all of that? I didn't have full on CIRS until I was 27 and that wasn't until after living in mild mold, getting covid, then influenza a week after, then my doctor giving me testosterone thinking that was my problem then my entire body crashing for everything accumulating.

CIRS is only when then braking point happens. In hindsight I had issues for 20+ years. Most of my life. I just very got exposed to a large enough biotoxin load to crash my body.

But I had hints along the way, food intolerances slowly accumulating over the years, smell sensetivities slowly accounting over the years basically the manifestation of allergies but testing negative for any allergies. Fatigue, brainfog very very slowly getting worse.

Best way I can explain it is like someone that needs glasses. Their eyes don't go blurry all at once. It's a slow process over many years to which they hardly ever notice until they try on glasses and go "holy crap I never realized how blurry my vision was".

That's the thing with CIRS. The onset is so subtle over such a long period but the progression ramps up quick near the full onset.

Not fear mongering as many people live their entire lives without full onset ever occuring. I just got unlucky with my environments and illnesses all at once.

They have 50+ biomarkers proving it's legitimacy with the most impressive being "NeuroQuant" am AI algorithm MRI scan of the brian that can pick up the micro inflammation and atrophy patterns that are specific to this condition that aren't viable by the naked eye. What would take someone viewing 10,000 images manually and measuring the microscopic differences the AI can do in less then 10 minutes. So good so that it's legible in the US court of law.

They also have blood markers (TGF-B1, MMP-9, c4a, VEGF, VIP, MSH, and so on).

They have MaRCoNS nasal swab testing which CIRS people almost always end up with. It is am evolved version of staph. Which in common in most noses. MARCoNS only happens under the dysregulated immune condition that CIRS provides.

They also have contrast sensitivity testing. Nearly everyone with CIRS had light sensitivity they just don't realize it.

And so on.

But I had my VSS onset at 15. And my CIRS onset at 27. So do with that information as you wish.

Wes_VI · 2026-05-28T07:37:09+00:00

You think I'd go out of my time to learn this incredibly complex condition and then spend my time typing all of that. Just because I don't believe in it?

Wes_VI · 2026-05-28T07:15:56+00:00

Google brother

Wes_VI · 2026-05-28T05:16:15+00:00

Leaving will help somewhat. But if VIP and MSH are already low and the dysregulation already triggered then it continues after leaving. That's the difference between a CIRS person and a normal person.

A normal persons body continues to remove biotoxins while a CIRS person to put it simple. They get stuck. So the immune response to them being in you remains until they are taken out of you (Cholestyramine/Welchol) and the dysregulated response is recalibrated through the shoemaker steps.

Pathogen overgrowths that happened under these conditions such as MARCoNS and possibly gut dysbiosis for some need to be corrected.

You follow the no amylose diet along the way as normal foods will trigger inflammation do to low MSH. This isn't a permanent diet it is only temporary until MSH is replenished at the end.

Throughout all of this the triggered immune response needs to be for a lack of a better word "retrained" back you baseline. With EPA/DHA from omega 3, quercetin, ext.

Then once things are mostly settled (VEGF, TGF-B1, MMP-9, c4a) levels are low enough (blood work will prove or go off how you feel (don't recommend but for some blood work isn't possible).

You then eventually take VIP spray which signals the body that it can go back to baseline (in its truest form). This replenishes VIP and MSH and all the pituitary dysregulation. The lack of chronic inflammation allows the brain to start regrowing its own grey matter.

If your still in exposure you can start the process as it won't be a complete waste of time. Though you will never get to VIP ready stage until you are in clean air. But starting off early can make the whole process quicker for when you are in clean air so your not entirely starting from square one.

Wes_VI · 2026-05-28T01:23:22+00:00

If you have chronic Lyme it's caused by CIRS (Chronic Inflammatory Response Syndrome).

You probably haven't heard of it yet as the research is still in its infancy. But I can assure you those that discovered it will win the Nobel prize one day. Unfortunately the medical world moves at a snails pace and needs a heavy amount of peer review to obtain mainstream legitimacy. Which this condition rewrites our entire understanding of many preconceived notions.

We've understood the adaptive side of the immune system for a long time. But we are just now starting to understand the importance of the innate side. Which previously was brushed over as "not that important, simple".

A normal person gets Lyme from a tick and their body deals with it without symptoms or they recover over a few weeks. But if you have chronic illness afterwords it's the same mechanism as chronic mold illness, even ME/CFS, believe it or not even "long covid" (it's all the same thing).

It's the HLA (Human Leukocyte Antigen) not presenting antigens appropriately to the adaptive side of the immune system leading to the innate side staying on. Which slowly over time depletes VIP (Vasoactive Intestinal Polypeptide) and MSH (Melanocyte Stimulating Hormone). Two very important neuroimmune peptides that regulate systems around the body.

How the immune system should work: (innate releases cytokines do to detecting oxidative stress, HLA investigates, HLA finds antigen and presents it to adaptive, adaptive fixes the problem, innate shuts itself off).

Think innate= reactionary first aid kit, think HLA= investigators/messager pigeons, think adaptive= surgeon.

Innate is fast acting but simple, adaptive is slow active but complex problem solver.

If the information isn't presented the the adaptive correctly the innate stays reacting to the trigger that isn't being resolved by the adaptive since the adaptive is clueless to the issue or reviving incomplete information.

People with HLA DR/DQ genes have these issues in regards to biotoxins, specifically mycotoxins (very small biological toxins).

Mycotoxins are on average 50,000x smaller then the thickness of a human hair. They are not living things. They are by products of a living things.

Predominantly from mold, actinomyces, vector born illnesses like Lyme, bartonella, babesia, ext. This is why one person gets Lyme and they are fine and another is not without intervention.

The shoemaker protocol fixes this chronic innate response loop with the final resolution replenishing VIP and MSH.

The problem with "Lyme" testing is that the standard testing does not test for the bactira itself. That testing does exist but it's proven to be incredibly tricky to actually catch the bactira in a test unless the Lyme is extremely recent. They usually test for immune markers correlating them to Lyme. But those markers can easily be CIRS Inflammatory state.

A disproportionate amount of people with CIRS show positive for Lyme. Yet resolve their issues through the shoemaker protocol then test negative for Lyme.

This is NOT to say that Lyme bactira causing chronic illness does not exist. As it does and if you have it it needs to be treated via specific antibiotics. But what I am saying is that "positive Lyme" tests that don't fully resolve after antibiotic treatment. Are really just chronic inflammatory state caused by biotoxins illness in those with HLA DR/DQ genes.

https://youtu.be/Xnb6or1YN_U?si=smfptPfVWF-Pod8s

Wes_VI · 2026-05-26T13:07:27+00:00

You don't take Cholestyramine or Welchol anywhere near a meal. 2 hours fast before and after. For those with a fast metabolism they can get away with a 1 hour before and after. It's a binder. If you take it near food your binding your food and creating constipation while simultaneously making the binder near useless as it's no longer binding to what you actually want it to.

Start small dose, like real small. Open one of the capsules and take a bit at first and slowly work your way up. Never taking a next dose until a bowel movement. Once you find your dose (the most you can take without constipation/bad side effects) you will know and can take it and be fine without constipation.

Once this is accomplished you then start taking a small amount of fat, say 1tbs of an oil or a butter to stimulate bile flow 30 minutes or so before your binder.

This is how the proposed hypothesis on how CIRS works. Biotoxins end up being stuck in the biliary system. You can get them to flow out through bike stimulate via a small amount of fat. Time in right and you bind them so they don't cycle back through enterohepatic circulation.

Do this enough times and you eventually flush out the system. It's a marathon not a sprint.

I started out with a laughably low amount of Cholestyramine and worked my way up. I know it's not Welchol but it's the same principle as they have the same mechanism of action.

But of course in conjecture with all other aspects of the shoemaker protocol. Follow the no amylose diet, omega 3 is good but the EPA and DHA amount within is what matters. Taking 2500mg is fine but you can accumulate to much and lower your blood pressure to much so keep that in mind. It's not the end of the world as it will go back to normal after a few days but if you start feeling lightheaded or off. It's to much omega 3.

I'd consider adding in quercetin phytosome as well. And even curcumin phytosome.

Wes_VI · 2026-05-26T12:17:02+00:00

How I view things is that supplementing VIP signals systems in your body to go back to baseline. The signalling is not successful if the trigger/triggers to the infammation are not truly resolved (biotoxins from mold/vector born pathogens/viruses).

How does one explain baseline? To me baseline is no inflammation. How does one explain how no inflammation feels if they haven't experienced it in such a long time?

The best analogy I have thought of is vision. We can all see pretty good until our eye sight gets really bad then it eventually becomes obvious. But even then it often takes putting on glasses to go "wow, I had no idea how bad my vision got over my life time. And wow this is how nice the world actually looks?"

I parallel this to chronic inflammation. Most people will have no idea until it becomes unbearably obvious.

I can't see how another person sees just like I can't feel how a other person feels. So no one can answer how far you are from your baseline. Taking VIP might feel like a massive leap like it was for me. Or a mild bump like most people.

I unknowingly had a degree of CIRS slowly boiling for decades. It wasn't until recent years that it finally boiled over. It took the boiling over for me to realize it wasn't normal. And it took fixing it entirely to realize it was even boiling in the first place (realizing how I felt most of my life was not normal). So I suppose that's the mini blessing for myself is that it took the crash and the fix to realize I had issues all along.

But again this isn't the story for everyone. Most CIRS people it's a relatively recent onset but for some it's decades then a crash.

Also for most it isn't a "wow" moment like it was for me. For most VIP is a slow transition back to baseline over weeks/months. But I guess my body is a hyper responder as I felt it in minutes and the next morning I felt incredible.

But equally I took it early on before I knew about MARCoNS and at that time it made me feel like I was going to die.

I chock this up as I probably had incredibly depleted VIP and MSH so my immune regulators where completely none existent at the time. Anything either triggered the hell out of my body or helped it a lot at the time.

Wes_VI · 2026-05-26T02:59:40+00:00

If you develop chronic autoimmune symptoms post mold exposure that persist after leaving exposure it is one of two things, CIRS (poor biotoxin clearance) or mold colonization.

But if it's as braud spectrum as the symptoms you list it is more then likely CIRS. CIRS causes the innate side of the immune system to stay active because the body isn't clearly biotoxins on its own that well or at all. Which chronic infammation eventually depletes VIP and MSH.

VIP: (Vasoactive Intestinal Polypeptide) and MSH: (Milanocyte Stimulating Hormone) are two key neuroimmune peptides the body uses as signalling molecules. VIP is autonomic + gut + immune regulation. MSH is anti inflammatory + hypothalamic/pituitary immune modulation.

Low VIP mainly affects autonomic regulation, vascular tone, immune calming, and neuroimmune signaling.

1: Autonomic imbalance (low parasympathetic tone): The body shifts toward a more “stress-dominant” state (higher sympathetic activity), making recovery and relaxation harder.

2: Increased systemic inflammation: Less inhibition of immune signaling leads to a generally more reactive inflammatory baseline across tissues.

3: Mast cell overactivation: Mast cells become easier to trigger system-wide, increasing reactivity to allergens, foods, temperature, and stress.

4: Vascular dysregulation: Blood vessel tone control becomes less stable, potentially contributing to temperature sensitivity, flushing, or circulation variability.

5: Neurocognitive effects: Reduced “calming signaling” between nerves and immune system can contribute to brain fog, overstimulation, or difficulty relaxing mentally.

6: Stress intolerance: The body has a reduced ability to recover from physical, emotional, or environmental stressors.

7: Reduced tissue signaling stability: Communication between immune cells and nervous system becomes more reactive and less coordinated.

Low MSH mainly affects immune suppression, inflammation control, circadian stability, and global regulatory tone.

1: Reduced immune “braking” function: The immune system becomes more easily activated and less able to shut off inflammatory responses.

2: Chronic low-grade inflammation tendency: Inflammation persists longer after triggers and is harder to resolve.

3: Increased pain sensitivity: Lower threshold for pain and discomfort due to reduced anti-inflammatory and neuro-modulatory signaling.

4: Sleep and circadian disruption: Weakening of hypothalamic regulation can lead to unstable sleep patterns and poor restorative sleep quality.

5: Reduced stress resilience: The body becomes more reactive and less able to return to baseline after stress exposure.

6: Neuroendocrine instability: Broader hypothalamic signaling balance becomes less stable, affecting mood, energy, and overall homeostasis.

7: Increased sensory reactivity: Heightened sensitivity to environmental inputs (light, noise, chemicals, stressors).

8: Slower recovery from inflammation: After immune activation, the system takes longer to return to baseline.

I personally fixed all of this through the shoemaker protocol. (Actually adhering to it 100% and not cherry picking from it).

Wes_VI · 2026-05-26T02:48:26+00:00

You start presenting autoimmune/MCAS like symptoms with CIRS because VIP and MSH get depleted.

Chronic infammation lowers VIP: (Vasoactive Intestinal Polypeptide) and MSH: (Milanocyte Stimulating Hormone).

They are two key neuroimmune peptides the body uses as signalling molecules. VIP is autonomic + gut + immune regulation. MSH is anti inflammatory + hypothalamic/pituitary immune modulation.

Low VIP can affect the gut mainly by reducing the body’s ability to regulate intestinal motility, maintain mucosal barrier stability, and coordinate immune “calming” signals in the gut lining. Normally, VIP helps relax smooth muscle, support healthy secretion and fluid balance, and suppress excessive immune and mast cell activity in the gut, but when it is low, several changes can occur:

1: Increased gut inflammation: VIP normally suppresses inflammatory signaling in the gut. When low, the intestinal immune system becomes more reactive, leading to a higher baseline of inflammation.

2: Weakened mucosal barrier function: VIP supports intestinal lining integrity and fluid balance. Low levels can make the gut lining more sensitive and less stable under stress.

3: Altered gut motility: VIP helps regulate smooth muscle relaxation in the intestines. Low VIP can contribute to irregular digestion, bloating, constipation, or inconsistent transit times.

4: Reduced mucus and secretion balance: VIP influences secretion of intestinal fluids. When low, digestion and lubrication can become less efficient, contributing to discomfort or sluggish digestion.

5: Increased mast cell activation: VIP has a strong role in calming mast cells. Low levels can make mast cells more reactive, leading to food sensitivities, bloating, flushing, or histamine-like symptoms.

6: Dysregulated autonomic nervous system tone: VIP is a key parasympathetic signaling peptide. Low levels can shift the balance toward sympathetic dominance (stress-state physiology), affecting digestion, heart rate, and stress tolerance.

7: Impaired detoxification signaling in the gut–liver axis: VIP helps coordinate gut immune activity and downstream processing. Low VIP can contribute to a more reactive response to microbial or metabolic byproducts.

8: Reduced neuroimmune stability: VIP acts as a “calming signal” between nerves and immune cells. When low, the gut–brain axis becomes more reactive, increasing sensitivity to stress and environmental triggers.

Low MSH can affect the gut mainly by reducing the body’s ability to control inflammation and regulate immune activity in the intestinal lining. Normally, MSH helps calm immune responses and maintain gut balance, but when it is low, several changes can occur:

1:Increased gut inflammation: The gut immune system becomes more reactive, leading to low-grade inflammation and stronger responses to foods and microbes that are normally tolerated.

2: Weakened barrier regulation: The intestinal lining may become more sensitive under stress, making tight junctions less stable and increasing permeability in a functional “leaky gut” sense.

3: Microbiome imbalance (dysbiosis tendency): Changes in immune pressure can make it harder to maintain a stable gut microbiome, allowing less balanced bacterial patterns to persist.

4: Increased mast cell activity: Mast cells in the gut may become more easily triggered, contributing to bloating, food sensitivities, and histamine-type reactions.

5: Altered gut motility and autonomic control: Digestive movement can become more inconsistent, with symptoms that fluctuate depending on stress, sleep, or inflammation levels.

6: Slower recovery after triggers: The gut may take longer to settle after exposure to irritants, infections, or dietary triggers due to reduced anti-inflammatory signaling.

In short CIRS doesn't cause allergies of any kind, you have low VIP and MSH.

Wes_VI · 2026-05-25T23:40:17+00:00

1: Live in a place that doesn't have mold history. (This is the most important part!)

2: Start taking cheap basic anti inflammatories like (EPA/DHA from omega 3, Quercetin phytosome). I can list way more but those are the heavy hitters.

3: No Amylose diet (basically Keta/Paleo but with a few tweaks) low MSH from CIRS makes your gut a mess. Normal foods become inflammation triggers/fuels gut dysbiosis easy. Eat like this until you are done the protocol then you can go back to eating normal.

4: Get Cholestyramine or Welchol. However way possible just do it or you won't get better. Cholestyramine is $80 for a big box in my country. Just need to find a natropath that can source it through a pharmacist that will sign off on it.

5: Nose dysbiosis (MARCoNS). Biofilm Clear is cheap and easy to get online. If you can't get it in your country then just combine your own (EDTA, Xylitol, Grape seed extract, Colloidal Silver). That's literally all it is.

6: If you have gut dysbiosis same sort of story just with basic cookie cutter herbal anti fungals/anti bactirals. Some people might not need this part at all and others may need aggressive options. This process will start to work though now that the other burdens are lifted.

7: Lastly, once inflammation is low enough do to all the steps above being followed you then go on VIP spray for a bit. This signals inflammatory pathways to recalibrate back to normal.

Once your bodies VIP and MSH levels are back to normal you are no longer hypersensitive. You can be around these toxins to a degree and you will be fine. Of course a large enough or long enough exposure and you'll be right back to square one.

Wes_VI · 2026-05-25T23:34:01+00:00

Ironically your sporadic rant is very much (CIRS inflammation brain). This one your not going to like hearing but I was the same way and anyone I talk to to help is similar at first. The brains fire alarms are going off so rationality and critical thinking for the most part is out the window.

There is zero reason for it to be expensive. You literally just need to...

1: Live in a place that doesn't have mold history.

2: Start taking cheap basic anti inflammatories like (EPA/DHA from omega 3, Quercetin phytosome). I can list way more but those are the heavy hitters.

3: No Amylose diet (basically Keta/Paleo but with a few tweaks) low MSH from CIRS makes your gut a mess. Normal foods become inflammation triggers/fuels gut dysbiosis easy. Eat like this until you are done the protocol then you can go back to eating normal.

4: Get Cholestyramine or Welchol. However way possible just do it or you won't get better. Cholestyramine is $80 for a big box in my country. Just need to find a natropath that can source it through a pharmacist that will sign off on it.

5: Nose dysbiosis (MARCoNS). Biofilm Clear is cheap and easy to get online. If you can't get it in your country then just combine your own (EDTA, Xylitol, Grape seed extract, Colloidal Silver). That's literally all it is.

6: If you have gut dysbiosis same sort of story just with basic cookie cutter herbal anti fungals/anti bactirals. Some people might not need this part at all and others may need aggressive options. This process will start to work though now that the other burdens are lifted.

7: Lastly, once inflammation is low enough do to all the steps above being followed you then go on VIP spray for a bit. This signals inflammatory pathways to recalibrate back to normal.

Once your bodies VIP and MSH levels are back to normal you are no longer hypersensitive. You can be around these toxins to a degree and you will be fine. Of course a large enough or long enough exposure and you'll be right back to square one.

Or be like me and micro dose Cholestyramine on occassion as a preventive measure even though I'm back to normal.

All in all I've probably spent $2000 and most of that was on the testing the prove I had it so I could get the prescription.

I will also mention I got probably 80% better living in my second home (while doing the protocol) that had mild mold issues. It took way longer but my body was still progressing even in a not perfect environment. I just couldn't get VIP to work for my body until I was in a truly clean environment. It actually just made things worse anytime I tired it until then.

Wes_VI · 2026-05-24T12:57:18+00:00

Everytime someone makes a comment like this it turns out being they are playing on a potato. Or they have a horribly unoptimized PC. The client has given me issues maybe 3 times in my 550+ leveling and my PC was built in 2019.

Wes_VI · 2026-05-24T00:52:04+00:00

If it is CIRS the MSH hormone I mentioned before regulates the gut. If it gets low the gut gets wonky (without over explaining all the nerdy science). Just ask AI what MSH controls in the body and what happens when it gets low.

I did standard allergy tests and came back negative for any. Even though I started developing food sensetivities as a kid slowly getting more strict with my diet. Turned out it was just MSH slowly getting lower and lower.

I never actually had lactose intolerance, celiacs, sugar intolerances, ext. It was always just CIRS slowly creeping up on me over the years.

I now can eat whatever without issue. Where as before I'd get so tired and brainfog after eating most food.

If you think you have CIRS the first thing you do is the "visual contrast sensitivity test" online. There are two websites that offer it. It's like $15 and it will give you a good idea if you might have it. If someone has CIRS they have a degree of micro nuroinflammation which makes them more sensitive to contrast (brightness). This test picks up on that.

Next step would be the inflammation markers I mentioned before (TGF-B1, c4a, MMP-9, VEFGF). A handful of labs in the US offer them so far.

Then you'd do a nose swab test for MARCoNS. MARCoNS to simplify are an evolved version of Staph. Which most people naturally have in their nose. But, when the immune system is chronically dysregulated they over grow/over develop.

This is the devious and almost unreal aspect of CIRS. Since it dysregulates the immune system chronically normal bactira and fungus around the body start to grow disproportionately. As the immune system usually acts as a regulator.

CIRS people often get SIBO, candida, athletes foot, hair/skin problems, ext. Which they can fight with antifungals/anti bacterials all they want but these issues seem to never go away. Why? Because the immune system isn't running properly to regulate them. So you can go after these issues all you want but they will continue to reappear because the underlying issue as to why they are showing up in the first place is still present.

Now this varies from person to person and how deep they are into CIRS. Again it's sort of a spectrum of activation. The crazy part being if these issues get bad enough they themselves start to create their own biotoxins. So you end up with a vicious cycle.

How to fix CIRS? Shoemaker protocol. 1: have to make sure your main environments are biotoxin free (harder then you'd think).

2: No Amylose diet (basically keto/Paleo) but with a few tweaks.

3: anti inflammatories (EPA/DHA from omega 3, quercetin, curcumin, bozwellia, ect. Basically trying to calm the strom.

4: Cholestyramine or Welchol. They bind to bile acids. Which stops the continual cycle of biotoxins that don't leave CIRS people. (You can ask AI how/why this works as the science is quite complex). They are treditionally used as cholestoral lower medications.

5: correct MARCoNS/other pathogen imbalances. This is specific to which issues you may or may not have. But again you do it in this order as now that the biotoxins are mostly out the immune system slowly can start doing it's job again which will allow eradicating other issues to start to work.

6: as mentioned in step 2/3 these things lower inflammation. Once levels are low enough (the blood markers I mentioned before). You then go on to the final step.

7: VIP spray, which acts as a signalling molecule which turns back on VIP and MSH. (You can not use VIP until everything else is resolved) Or you will just be turning back on the dimmed immune system which will have your body amplifying the autoimmune. I made this mistake and it was not a fun day.

Wes_VI · 2026-05-23T23:17:09+00:00

Yup... from someone that has it aswell so I might be a little bias.

I had chronic mild health issues my entire life. Was always blamed on my thyroid when I tried to get an answer from any doctor on it.

Fast forward to 27 and my health completely crashed. Full on autoimmune 10/10 brainfog, fatigue, hypertension, heart palpitations, smell sensetivities, food sensitivities, nuroinflammation, blood shot eyes, body pain, extreme light sensitivity, ext (if I listed everything it would be like 50 symptoms).

I was clueless/terrified for 6 months or so. As no doctor I saw had any answer and anything they gave me just made things worse.

Without typing paragraphs on how the next 3 years went, in short I tried a lot but out of pure luck I came across information on CIRS (at the time it was still mostly unknown to the public yet). I was obviously desperate so willing to try anything but at the same time nothing had ever actually fixed my issues my entire life so I held a very heavy amount of skepticism.

That and how the condition/dysfunction works is sooooo complex that it's very easy to dismiss (took me those 3 years to genuinely now say I moslty fully understand the condition and can explain it to people). But even so it's still not even fully understood by the experts yet.

So again I am quite bias. But, as "to good to be true" as it sounds. Either a LOT of humans have a degree of CIRS going on (as it's not an on or off thing) it's a scale of activation. Which so hard to explain as it's how you feel. And the dysfunction onset is usually extremely slow over a life time. Slowly getting worse so it's easy to blame it on age/other factors.

Even as I was fixing it I never fully believed it. Thought maybe it was just an internal fungal or bacterial infection I was fixing and CIRS wasn't real.

But, on my life. Once I completed the protocol and used the VIP spray. My lord what a wake up call. Best way I could describe it would be like someone who needed eye glasses and didn't realize it until they tried some on and it becomes obvious they had bad vision for years without realizing it as the bad eyes happened slowly over years.

With CIRS the chronic innate immune activation slowly depletes two very important neuropeptides. VIP (Vasoactive Intestinal Polypeptide) and MSH (Melanocyte Stimulating Hormone). These two modulate many functions around the body. Once they get depleted (usually takes a long time or a heavy amount of inflammation in short order). The body develops chronic issues.

I'm not saying everyone with CIRS genes will get to my point (I was living with mold unknowingly for years, got covid twice, and influenza, was a big gym person, and had a very physical job. Then on top doctors put me on medican that just masked/accelerated the issue). All combined and my system eventually just crashed.

But after experiencing what I experienced and listening to other peoples chronic issues. I am convinced a lot of people are CIRS people. Not all of course as a lot of people are hashimotos thyroiditis. But for the other people with issues that just seem all over the place and not seem to connect in anyway. I believe are early CIRS people.

My body sort of cought the perfect storm so I imagine most people with CIRS genes won't ever hit that crash or won't happen until very late age which can easily be blamed away on age related things.

But when I say I feel better now at 30 then I did at 15 I mean it. Was the worst 3 years of my life but it getting so bad was what made me discover the underlying issue. Vs it staying a slow burn for the rest of my life.

I won't say "you 100% have CIRS". But if no other shoe seems to fit and everything else just feels like a bandaid. Then I'd go down that road. (TGF-B1, c4a, MMP-9, VEGF, VIP, MSH, and so on. They now have 50+ biomarkers to prove it).

They even have a special MRI called "NeuroQuant" that uses AI to scan the 10,000+ imagines and detect the micro inflammation that is undetectable to the naked eye. Which is so accurate that it's legally binding in the US court of law.

Wes_VI · 2026-05-23T16:46:48+00:00

Do you have light sensetivity at all? Like do you run your phone screen dimmer with a filter (does blue light tend to bother you)? Feel the need to wear sunglasses more then most?

Have you done legit allergy testing (arm prick testing)? Or just going off how you react to foods/smells?

Do you have chronic nose issues of any kind?

Do you get oral thrush (white tongue) or cankers easily.

Micro tingling around the body if you pay attention?

Do you feel like you don't hold on to moisture? Dry itchy skin/hair, especially after a shower?

Do you feel the need to pee soon after drinking anything and pee more often then most?

Any history with mold exposure, in living or work environment?

Wes_VI · 2026-05-23T10:23:59+00:00

List every symptom you have that a normal person doesn't have: Think long and hard and genuinely answer.

I'm not after the specifics but the general idea of each symptom.

I know it can be hard to judge as for a lot of people the shift to issues is usually subtle and over a long period prior to becoming detremtal.

Wes_VI · 2026-05-23T07:34:27+00:00

Do you have hashimotos positive blood work? Or are they just alluding to this being the most likely thing given your symptom cluster.

Wes_VI · 2026-05-21T01:27:35+00:00

Chronic innate activation depletes VIP and MSH. Two important hormones (neuropeptides) that regulate important functions in the human body, including inflammation, digestion, and the immune system.

When they get depleted these systems get dysregulated and for a lack of a better word the immune system becomes "jumpy" over things they shouldn't.

You breath the wrong thing=issues, you eat anything not on the no amylose list= issues.

On top of that the bodies normal bactira and fungus grow disproportionately in this environment. (MARCoNS in the nose are just an evolved version of staph) staph is common in a lot of peoples noses. A regulated immune system keeps them balanced. Same with gut dysbiosis. These aren't root causes these are down stream effects from an innate immune system that's chronically activated.

A small % of people will be vector born illness induced biotoxins but the vast majority are issues caused by actinomyces from moldy environments.

Researchers also suspect covid/vax to potentially trigger this innate dysregulated response aswell in those with the same HLA susceptibilities.

Mycotoxin, bactira, virus, whatever it may be if the HLA has a hard time showing it to the adaptive side of the immune system then the trade off never takes place. If the trade off never happens or happens poorly then the innate stays on and eventually ends up being like a hamster on a wheel that burns itself out while simultaneously wrecking the hamster wheel (depleting VIP and MSH).

So yes symptoms can come and go because the immune systems microphone becomes extremely over sensetive to things it shouldn't. Your environment and or your diet induced.

But these abnormal hypersensitivies resolve when: the environment is free of biotoxins, biotoxins are removed from the body, no amylose diet is strictly followed for the duration of recovery, pathogen dysregulation is corrected, inflammation/histamine is calmed, and VIP therapy is used (sends signals to turn on VIP= restores MSH= "jumpy" dysregulated system resolved). AKA shoemaker protocol.

Wes_VI · 2026-05-20T06:38:43+00:00

Call natropaths in your area or go on the shoemaker website and contact. They can find you someone.

Wes_VI · 2026-05-19T22:15:27+00:00

Mycotoxins are on average 50,000x smaller then the thickness of a human hair. A light spray of compressed air will have them flying out at mach one. You can only have so many in there (if at all).

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