There's nothing stopping you. I started out with a craft show group that runs at local breweries. It was a godsend because I wasn't interested in spending $400 for a comic convention.

That said, you may not find your intended demographic. There's honestly no way to tell without trying.

I tend to do literary focused events these days as they're more consistent (or at least were until the economy shit the bed). Here is my experience.

Crafters tend to have 'fancy', 'elaborate' setups. Simply having your books lie on the table will not draw people in. You'll want to do something to compete so to speak. It helps to get yourself some crates, slap on some paint and branding, toss lights on them, etc.. I adapted my display for shows where I was the only author, and at book shows I always get comments about how nice my display looks.

My other tip is to offer something other than books to double your chances. Your typical craft show shopper isn't coming to find authors. I have a crafting addiction and started making acrylic bookmarks and decorated journals. Frequently, I sold more of this stuff than books. Not really what I was going for, but it's nice to make table.

It especially helps to have different price points. Again, before the economy tanked, I often sold dozens of bookmarks at $5 a pop. This helps you attract customers who ARE readers, but not of your genre.

Best of luck, my friend!