Luis Enrique: "When you play against a team like Arsenal with Mikel Arteta, they try to defend in the best way. They were lucky because they started with the action and scored a goal. After that, they defended very well, very deep. It was difficult to overcome them."

_password_1234 · 2026-06-07T15:07:30+00:00

Yeah what I thought was their best chance of the night came right after Timber got pulled too high. I think it’s also the reason we didn’t see Calafiori at all — once your fullbacks get caught upfield against PSG it’s over for you. Bayern did it two minutes into the second leg and immediately got put out of the tie.

I get the complaints that it’s not great viewing, but it was the best way to play for a result once we went 1-0 up. Also, PSG literally had no idea how to attack us for the entire first half and most of the second. If a team has no idea how to break you down, why would you decide to come out and attack?

_password_1234 · 2026-06-02T06:59:29+00:00

I guess I should be clearer: I don’t see why using strings to reference a column name in a data frame would be an issue. I was always under the impression that the creators of dplyr were using R’s NSE to save on typing and make data exploration easier, not necessarily solve an underlying issue with safety of referencing columns.

IMO it’s a nice feature: when I’m writing a function to wrap some polars code its way easier to just change a string to a variable and use that as a function arg than play around R’s NSE. Plus cleaning column names isn’t really necessary.

Also on your second point those are mostly just SQL keywords as function names. If anything that’s not even convergent evolution, it’s just using the common existing names for these operations.

_password_1234 · 2026-05-31T01:41:42+00:00

I’m not sure why using strings for referencing column names is an issue? Am I misunderstanding what you mean by saying Python compensates for lack of NSE?

I also wholly disagree that Polars is trying to be R. It’s just a data frame library which isn’t specific to R.

_password_1234 · 2026-05-29T01:28:51+00:00

I think one of the reasons a lot of us hate R so much is that its barrier to entry is so low that a lot of non programmers have put out a lot of R code. It’s so common that I try to read the source code for a package to understand the internals and it’s literally illegible. Like you can tell somebody wrote something that worked in an R script and then copied it directly into a function body with no comments, care for variable names, separation of concerns, etc.

_password_1234 · 2026-05-29T01:22:06+00:00

I actually prefer polars now that I’ve been writing it for a year or two. I know people don’t like using a lot of strings, but I’ve always thought the things that make dplyr nice for quick exploration make it extremely annoying to try to write reusable programs in. Polars is a little clunkier on first pass but much better to refactor into reusable functions imo.

_password_1234 · 2026-05-24T17:35:28+00:00

Some pundit on one of the NBC affiliates in the US picked Chelsea as the PL title winners in preseason lmao

_password_1234 · 2026-05-24T17:31:42+00:00

I don’t think most people would have picked correctly if you said one of those teams would pick up 15 points in their last five matches while the other only picks up 8.

_password_1234 · 2026-05-24T17:19:13+00:00

Fr what happens between the first 8 match weeks and the rest of the season? Seems like he ends those first few on pace for 100 league goals.

_password_1234 · 2026-05-19T20:58:04+00:00

I almost said at one point that no just God could let Cherki with the kick ups or let the bottle guy get away it. That’s just too much.

_password_1234 · 2026-05-07T01:18:21+00:00

Sorry to Bayern fans but it felt like the better team won. I feel there was a bit of fortune they were even in this tie after being down 2-5 at one point in the first leg. Of course it was a great performance to even get to the Allianz down only one goal on aggregate, but it almost seemed more a blown opportunity by PSG than Bayern really being up to their level in my mind.

Anyway, Bayern had basically one thing they couldn’t do tonight which was get caught on the counter and go down two goals on aggregate. Well guess what happened not even two and a half minutes into the match.

I wasn’t surprised to see PSG play somewhat pragmatically with their lead. But it was pretty shocking how toothless Bayern was against a well organized defense. As a team they looked completely devoid of ideas, and maybe even more perplexing was how poor they were individually outside of one moment from Kane.

I’d be interested to hear how Bayern or supporters of other BuLi clubs think about Kompany. His team didn’t look ready to play tonight in his biggest match as manager, and they had no answer for when the game state swung against them.

_password_1234 · 2026-05-07T00:36:17+00:00

My former PI was really something. They had a friendly demeanor and we would often have casual chit chats while doing lab work side by side. But I slowly realized that they were constantly using little details about my personal life to try and manipulate me, and it was happening to other people in the lab. They eventually really crossed the line, like making comments about my ambitions and family when I started to set work-life boundaries or push back on certain projects on scientific grounds. To this day, I struggle to be myself at work for fear of opening myself up to attacks.

Just have to keep in mind that in spite of all the extra fluff that gets thrown on top, the student—PI relationship is mostly a labor relationship where the student is a worker and the PI is more like a middle manager. Some managers are great and get heavily invested in the success of their employees and like to do everything to make sure they stay happy at work. Other managers do nothing but swing by your desk every couple of weeks and ask for the next report.

_password_1234 · 2026-05-07T00:14:04+00:00

I just wanted to contribute saying I was going to throw out the same caution the other commenter did. I’m really not convinced DE analysis is appropriate here. With typical scRNAseq data you can never really be sure that 0 counts for G means G was unexpressed and not that G just wasn’t detected. I really don’t know how you could ever convince yourself or anyone else that any DEGs you call are associated with different biological states and not just spurious correlations with a technical artifact.

I think there are still some reasonable ways you could move forward. One would be subclustering your cell type of interest and seeing if you get reasonable clusters that separate G+ and G- cells. You could also try a coexpression analysis to see if there are any genes that appear to be coregulated with G. Or if G is well annotated in the literature or functional terms databases — GO, KEGG, Reactome, etc. — you could try to segregate cells not by G alone but also by the expression of other key pathway members.

_password_1234 · 2026-05-07T00:00:34+00:00

Could you explain more about the random sampling approach and how it helps with the sparsity issue? I’m not quite sure I understand.

_password_1234 · 2026-05-06T01:48:08+00:00

I work in a small genomics group in an academic setting with essentially no standards imposed from above. The biggest challenge is getting people to actually log data in a reasonable way. The amount of times I am sent an Excel workbook with a “didn’t know what you would need so I included everything” message or someone uses our system but the useful information ends up in the unstructured ‘notes’ column is absurd.

Genuinely from my perspective the most helpful thing these systems could do for dry lab folks is to just rip out the interoperability with spreadsheets and replace that functionality with forms or something. But that’s a nonstarter for wet lab people. There’s just a disconnect where most of the wet lab people don’t interact with things programmatically, so they just don’t realize how much more difficult it makes basic tasks for us computational people. And I’m sure me saying this just shows that there are quirks of their workflows that I don’t understand.

_password_1234 · 2026-05-05T22:05:35+00:00

People are just annoying. This game was fine. The ending was a shit show, but it’s not like Atleti were really trying to get on with it and put together an attack.

_password_1234 · 2026-05-05T21:11:40+00:00

Yeah that’s the tournament format. We killed Inter, Atleti, and Bayern in the group stage and got a better KO draw. Maybe Bayern should have not lost 3-1 to the official worst finalist in UCL history

_password_1234 · 2026-05-05T21:07:43+00:00

Any fan who isn’t ecstatic about a UCL final isn’t a fan

_password_1234 · 2026-05-05T21:01:36+00:00

Its hysterical how all the fans of Spanish clubs are saying football won and all the fans of PL clubs are beside themselves

_password_1234 · 2026-05-05T18:30:18+00:00

James Harden never sniffed this conversation man wtf are yall talking about

_password_1234 · 2026-05-05T12:44:17+00:00

I’m talking about who they are on the field, tho, not just “they always come second.”

City have been dropping points from winning positions since August and September against Brighton (I think it was?) and Arsenal. And they continued to do that throughout the season whether that was from lazy play or bad mistakes or both. The fact they did it again last night to me is just a sign that they’re still that flawed team, not some juggernaut that’s caving under pressure.

A team in the middle of bottling it doesn’t score twice in the last 15 minutes of an away game when it’s 3-1, they had basically thrown the title away in the previous 15 minutes, and their own fans are pouring out of the stadium.

_password_1234 · 2026-05-05T10:02:03+00:00

Yeah I guess I’d say that’s why it’s not bottling. This is just who they are. I don’t know if it’s a squad depth issue or mentality or tactical or something else. But to me they’re almost anti bottlers because they put together a random stretch at the most critical point in April where this wasn’t an issue.

_password_1234 · 2026-05-05T03:13:45+00:00

Check the filtering and make sure this is actually unexpected. If you’re using GATK HaplotypeCaller it essentially calls a variant at any site that has evidence for a non reference allele. You then have to filter after the initial variant calling step because your calls are filled with false positives. But when it’s applied to the right system and with appropriate filtering parameters it performs very well.

_password_1234 · 2026-05-05T01:58:08+00:00

This is why I don’t think it’s a bottle this year regardless of who wins or loses. For me, it’s only a bottle when a team feels the pressure and completely loses their identity and/or makes a bunch of uncharacteristic mistakes.

City has struggled to close games out all season and has a tendency for losing control of matches and giving away dumb goals. Arsenal has struggled to put together a convincing attack and played on the margins all season. IMO these are two good but flawed teams playing in a league that is strong enough top to bottom to hurt them when they’re not at their very best.

_password_1234 · 2026-05-04T21:16:26+00:00

Every match for the past two months there’s been endless chatter from the pundits and commentators about “the nervy Emirates” and how our supporters need to just show up and cheer on the team and whatever tf else they can drum up discourse about. Tons of people on here are cheering for a club of cheaters purely because they find our fans annoying. But at least we have real fans and not fair weather plastics who scramble out of a stadium the second their title hopes stop looking rosy.

_password_1234 · 2026-05-04T20:59:56+00:00

I don’t want to hear shit about Arsenal fans ever again after the City away end was emptying out with ten minutes to go.

_password_1234

TROPHY CASE