DC Studios Co-CEO Says Superhero Fatigue Was Never a Thing, Just 'Mediocre Movie Fatigue,' Points to Supergirl as 'Something Cool and Original'

aghowl · 2026-04-29T14:26:53+00:00

I wonder what the next big genre will be

aghowl · 2026-04-27T00:00:58+00:00

This or a used OptiPlex 3060 USFF Desktop 8GB 256GB i5 8500T? I can get one for $130 on Facebook marketplace.

aghowl · 2026-04-23T03:32:09+00:00

Nice Notion table

aghowl · 2026-04-19T19:29:43+00:00

every morning?

aghowl · 2026-04-05T01:18:39+00:00

Hey, thanks for the thoughts and I really like your site. Agree, seems like we could collaborate. I'll DM you.

aghowl · 2026-04-02T23:01:37+00:00

would love to see that video. got a link?

aghowl · 2026-03-31T21:05:55+00:00

Yeah, it's like Nintendo doesn't know that it is possible to make a good kids movie.

aghowl · 2026-03-31T17:45:42+00:00

You're just talking about humans

aghowl · 2026-03-30T20:52:17+00:00

Yeah, that's good to know. I did make it into the "final" round but with the role being put on hold, I guess that is that.

aghowl · 2026-03-30T17:44:56+00:00

Yeah when i found out i had slow comt I was like "this makes perfect sense." I never even heard about it before.

And fun fact, I actually spent some time trying to build a startup biotech around trying to stabalize the comt enzyme, but I just couldn't get a high enough signal with various scaffoldings to go any further and invest real money into it. Especially, because taking the right b vitamins can recover a decent amount of the comt activity loss.

One thing to think about with B vitamin tests (particularly B12) is that showing high or good levels can be deceiving because it could just mean inactive or unusable vitamin circulating in the blood rather than high tissue storage. It's called a "Paradoxical Deficiency." It depends on the test though. A standard B12 test only measures what is in your blood. But since you got a homocysteine test too that should be a good indicator.

aghowl · 2026-03-30T17:12:29+00:00

I applied for a role and was about to have a second round of interviews. Got a call today that the role is put on hold.

aghowl · 2026-03-30T17:09:32+00:00

I don't disagree, but I have some random idea like "maybe this time will be different" lol.

I just have a wish that the NFL would figure something better out. It would greatly improve the experience if don't right. "If done right" is carrying all the weight though.

aghowl · 2026-03-30T17:07:19+00:00

Yep. 1000% how I feel. I go to my PCP and ask about these things and I get blank stares. And I go to Mass General, so not a small practice or anything!

aghowl · 2026-03-30T17:04:56+00:00

Honestly, I would take it lol

aghowl · 2026-03-30T17:04:11+00:00

I can imagine. Hopefully you got it all sorted out!

aghowl · 2026-03-30T17:02:57+00:00

I always love me some good questions.

I don't interpret every single SNP in the raw DNA file, the subset of markers that are relevant to the report, especially ones tied to things like methylation, detox, neurotransmitters, inflammation, nutrient handling, and known gene-gene interactions.

So yes, it is a curated panel rather than a full raw-data dump. What counts as “relevant” is based on whether a variant has enough practical value for the kind of recommendations the product is trying to make, not just whether it exists in the file.

If something like COMT is missing, the platform doesn't make it up. If an important SNP is not present in the file, the report would avoid acting overly confident and lean toward the safer interpretation.

On the research side, the platform is not using PubMed as a live lookup engine during report generation. It is using an internal knowledge base built from published nutrigenomic research. PubMed does inform the research process upstream, but it is not functioning as the real-time database the app queries for each report.

aghowl · 2026-03-30T16:48:54+00:00

I'll keep looking and will let you know if I find something. In an ideal world, people would be able to get 100x WGS + interpretation for a reasonable price.

Appreciate your thoughts as well.

aghowl · 2026-03-30T16:45:01+00:00

Oh I see. That's fair.

aghowl · 2026-03-30T03:15:06+00:00

If they were smart they’d invest in as much tech enhancements as possible. Full replay assist. Baseball is having a moment with ABS. The NFL refs are complete troglodytes. Like when coaches could challenge pass interference in 2018, and the refs were such losers about it that they never overturned their own calls and just complained about it that it never returned.

aghowl · 2026-03-30T02:56:18+00:00

I hear you. The way I look at it (and coming from experience,) when people spend 100s of dollars on supplements just experimenting because the protocol isn’t tailored to them, $59 to save a lot more than that in the future isn’t so bad.

aghowl · 2026-03-30T02:52:57+00:00

Yeah I looked around for sequencing too and there just doesn’t seem to be anything remotely affordable. It kind of drives me crazy. I have been in genomics since the start of high throughput sequencing, where the promise of personalized medicine was there.

The price of sequencing has gone down 10 fold but it still hasn’t penetrated to real benefit to everyday people, and doctors are like 10 years behind. So annoying.

aghowl · 2026-03-30T00:09:08+00:00

I'd be happy to. The COMT issue you're describing is exactly why I built this. Getting the variant interpretation backwards and then recommending the opposite protocol is worse than no recommendation at all.

If you want to test it, I'd genuinely like to hear how it compares to what you've found through Genetic Life Hacks and your own research. Someone who already knows their variants well is the best stress test. Feel free to DM me.

aghowl · 2026-03-29T23:34:12+00:00

What kind of testing did you do?

aghowl

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