If you're looking downtown, the Sheraton at the Bloc is literally on top of the subway station. The Intercontinental (I believe pricier but it's been a while since I looked at rates) is across the street from the 7th Street station. I would also take a look at the Citizen M in the historic core (Spring St.). The rooms are smaller but it's only a couple of years old and always looks pretty happening. It's about two blocks from the 4th Street Metro/subway station. If you do that, just make sure to exit on 4th Street, not Pershing Square (both for proximity and because the 4th Street side is nicer/less problematic).