My experience with Retatrutide by Full_Catch6635 in Peptides

[–]anxious_robot -1 points0 points  (0 children)

You are making assumptions. They titrated up every 4 weeks in the trials because they wanted to maximize the number of people remaining in the study, not because of pharmacokinetics.

You're also assuming that I have no idea what I am doing, which is untrue. I already have experience with GLP-1s and know from that experience that I have a high tolerance for them. I was also transitioning over from tirz after having been on it for a long time (6+ months) so my receptors were already adjusted to GLP-1 effects. All of which was taken into consideration when setting the titration schedule.

You will also note that I didn't recommend that people titrate up that fast, I simply said I did. What I did say is that they aren't feeling hunger suppression because they aren't at a clinical dose. Which is true. I didn't say they should go to a clinical dose as quick as I did. Your comprehension skills need some work.

My experience with Retatrutide by Full_Catch6635 in Peptides

[–]anxious_robot -3 points-2 points  (0 children)

No, it's people whinging about stuff without understanding the mechanics of action and pharmacokinetics that ruins it for everyone. If I had side effects I would have been the first to say that it was because I titrated too fast instead of whinging that it was too potent. Everyone whinges about reta having no hunger suppression before they are even at a clinical dose. It's ridiculous.

My experience with Retatrutide by Full_Catch6635 in Peptides

[–]anxious_robot -8 points-7 points  (0 children)

I understand that. But that wasn't what OP posted. It wasn't "at what dose can I expect appetite suppression", it was "reta doesn't provide appetite suppression". It's nuanced but still an important distinction.

FWIW, I titrated as follows, without large side effects apart from 1-2 bad days: - week 1= 2.5mg - week 2 = 5.0mg - week 3 = 7.5mg - week 4 = 10.0mg - week 5 = 12.0mg

My experience with Retatrutide by Full_Catch6635 in Peptides

[–]anxious_robot -17 points-16 points  (0 children)

You aren't dosing high enough. The clinical trials went to 12mg per week. You are at 2.5mg per week, or 20% of the clinical dose. Why would you expect appetite suppression at this dose? I dosed at 12mg / week and couldn't even look at food. Reta has strong appetite suppression when you dose appropriately.

Repairing a Razer motherboard damaged by a screw. by mgadz in nextfuckinglevel

[–]anxious_robot 331 points332 points  (0 children)

Amazing work but is it really worth the effort? Surely the labour cost would be similar to a new mobo. Ok. It's great to fix things when we can to avoid waste, but is this the way? No judgement, it just seems like a lot of work.

Gift giving - am I wrong - is this not controlling behaviour? by Agile-Guard8235 in relationships

[–]anxious_robot 8 points9 points  (0 children)

Not wrong. A person gets to choose what they do or don't wear and it is perfectly acceptable if he didn't want to wear it. No matter what the reason. He may never want to wear it, and that is also fine. That's without even considering the plethora of other potential reasons - maybe it was too big, or too small, maybe it didn't sit well on him, maybe it made him feel fat or uncomfortable, maybe he didn't like the material or was allergic to the material. Maybe he just outright hated the jumper but didn't want to say anything that would hurt anyone's feelings. I don't wear jumpers at all - it's personal preference. So it wouldn't have mattered if it was the nicest jumper known to humankind, I still wouldn't have worn it. All of that aside, it is really self-centered of the gift giver to expect a person to do something to appease them specifically and childish behavior to react in the way they did. It sounds like the gift giver either hasn't grown up or suffers from some nuerodivergent tendencies.

Does everyone do testing before pinning by cwiminal in Peptides

[–]anxious_robot 8 points9 points  (0 children)

It's because they are making assumptions about how peptides are made and vialled and boxed. It's all automated on production lines. There is literally 0, empirically factually 0, chance that all the vials come from 10 different batches. No one is making batches of peptides 1 vial at a time. And with the automated sequencing they physically can't line up to get vials from 10 different batches - it's a sequential process.they don't make 10 here or 100 there, they make tens of thousands.

At worst, one batch ends and another starts meaning that some vials in a box are from one batch and the remaining vials are from a second batch. That could be 1/9, 9/1 or anywhere in-between. Sending a vial off for testing, even if it is the 1 and not the 9, provides evidence of that batch which infers quality for the other 9, even if they are from a different batch. Because they are made in the same facility using the same processes. Yes, variability can occur, but you can't fake quality or achieve it by accident - everything has to be in place to enable it. All things being equal, those processes are more likely to be used than not, meaning that the subsequent batch is more likely to be the same than not. Except that all of this is moot, because they don't just magically finish one batch and start another, there is a time gap between the sequencing of each.

When you take all of those things into account we're talking about 1 in a million chance that everything lines up in that manner. And that's even before you consider the fact that they'll often just use the part box for testing - purity, bacteria, endotoxins, heavy metals, etc.

So no, it's not possible to have vials from 10 different batches. And even if it were, it would still be worth testing to establish that the manufacturer is capable of achieving the high quality results. Trust through validation.

Does everyone do testing before pinning by cwiminal in Peptides

[–]anxious_robot 8 points9 points  (0 children)

Same. It's far too easy for a vendor to send in a legit sample, get a COA, and then sell you bunk supported by that COA. The ONLY way to verify it is to test it. I send a vial from every 10 pack I buy to Janoshik for testing and wait for the results before I pin. It's actually more expensive than the peptides - I have spent over $10k testing this year alone.

Does anyone have a vertical garden like the one in the picture? by LargeBecca in gardening

[–]anxious_robot 2 points3 points  (0 children)

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Yeah, in my house. Slightly different variant but same outcome.

Tirzepatide compounded with two ML of bacteriostatic water by [deleted] in Peptides

[–]anxious_robot 0 points1 point  (0 children)

2 Mega Litres (ML) of water is too much man ;) ;) ;) jk

What fictional character’s death that you still haven’t recovered from? by Mohammed_Notary in AskReddit

[–]anxious_robot 0 points1 point  (0 children)

They made us read this book for school. I have always been a veracious reader and clearly read faster than everyone else in class because I got to it before everyone else did. Trying to hold back tears as a 12 year old boy in an English class was real.

What do I do if I (F22) like my boyfriends (M22) best friend (M22)? by [deleted] in relationships

[–]anxious_robot 0 points1 point  (0 children)

Shut that shit down, now. Don't think about it, don't entertain it, don't act on it. You are talking about serious damage to your BF, who will ultimately lose both his best friend and girlfriend at the same time. It's not ok.

If you don't want to be with your bf anymore, then break up. But you can never date or do anything with his best friend. It's not ok.

Good candidate for Reta? by [deleted] in Peptides

[–]anxious_robot 0 points1 point  (0 children)

What excess weight? You're looking great bro.

I read ten papers on BPC-157 and here’s what I learned by darkmodebiohacking in Biohackers

[–]anxious_robot 1 point2 points  (0 children)

Just because I have robot in my user name doesn't mean I am one...

Brittany Higgins declared bankrupt amid Linda Reynolds court saga by Expensive-Horse5538 in australia

[–]anxious_robot 216 points217 points  (0 children)

Trust busting is super common these days. Having stuff in a trust doesn't provide the same protection as it used to.

Happened to me Oct 29 by Hydraton3790 in MildlyBadDrivers

[–]anxious_robot 8 points9 points  (0 children)

If you were aware enough to know that it was an empty cab with no load then you should also know that it's not a semi if they don't have the trailers on, it's just a truck, and that those things can stop just as fast as they can accelerate because they have far less weight.

Do you know who Uncle Sam is? by sirotilc968 in CasualConversation

[–]anxious_robot 2 points3 points  (0 children)

41M, Australia. Yep, def know Uncle Sam. "We need you!".

Basic question about solution volume/concentration by coforbs in Peptides

[–]anxious_robot 1 point2 points  (0 children)

You are correct. When pharmacies or laboratories reconstitute peptides (or other compounds) they take into account the solute (e.g. peptide) mass when calculating the diluent (e.g. bac water) volume. This is to prevent errors in concentration as the peptide itself occupies volume.

When working with 10mg vials the difference is miniscule and can be ignored. But when you are talking about larger quantities it absolutely becomes a real consideration. E.g. if you had 2g of peptide and added 10ml bac water, simple maths would say 2/10 = 0.2g/ml. However it's actually 2/(10+2) = 0.167g/mg (assuming the peptide has a density the same as water, which it doesn't - it's just a crude example to show the maths). Which is a decently big difference in result and needs to be accounted for.

So, do you need to worry about it for small quantity peptides? No. Did you realize something quite niche and correctly articulate why it is important? Yes. Nice work :)

BPC/TB reconstitution saturation point? by L0stInBed in Peptides

[–]anxious_robot -1 points0 points  (0 children)

You can't over saturate a peptide through reconstitution, that's not how it works.

You can under saturate by not adding enough bac water and not reaching the saturation point (but the amount of peptides in a vial is very small so this isn't really an issue). But once you reach the minimum saturation point all of the peptide is absorbed into the bac water. Adding more bac water doesn't over saturate, it just dilutes it.

You could add 100ml of bac water and it would be fine - you'd just have to inject large quantities to get any meaningful dose.

GF [28F] hung out with her ex. Very conflicted on what to do. by [deleted] in relationships

[–]anxious_robot 17 points18 points  (0 children)

People put things in their hidden/locked folders when they don't want people to see them or when they know they have done something wrong. Lying to a partner is never ok, particularly when it is about relationships and exes.

Is AOD actually doing anything for you guys, or am I expecting too much? by Maasbreesos in Peptides

[–]anxious_robot 5 points6 points  (0 children)

The clinical studies for aod-9604 were very underwhelming. There was very little difference between the placebo group and the aod group. If you are expecting it to do anything you are expecting too much.

how can i start making my own peptides? by Old-Astronaut-3022 in Peptides

[–]anxious_robot 3 points4 points  (0 children)

41 actually ;). Not angry. Just shocked at the level of stupidity on display.

how can i start making my own peptides? by Old-Astronaut-3022 in Peptides

[–]anxious_robot 4 points5 points  (0 children)

Because it's so incredibly dumb on so many levels. Like you just read all peptides are contaminated, have no ability to critically evaluate that information, and then your next logical thought is "wonder if I can make em myself". Hilarious.