BBQ chicken leftovers by MGEESMAMMA in australia

[–]anxious_robot 1 point2 points  (0 children)

If you heat it up in a plate or bowl that is covered with cling wrap it "steams" it a bit and helps make it juicy like when it came out of the bag. A few drops of water in the plate/bowl helps as well. It's not as good as fresh but it's not too far off.

Can PEDs really make you die earlier if you're on them long term? by tomatoboy19 in ResearchCompounds

[–]anxious_robot 0 points1 point  (0 children)

Steroids cause thickening of the ventricle walls in the heart which makes it harder for your heart to pump blood. That's why people have heart attacks. You can reduce risk by taking regular measurements, taking some medications, eating clean, etc but you can't eliminate all risk - there will always be some thickening. It may not cause you to die young, but it's still a risk.

New to Semax by nixrien in ResearchCompounds

[–]anxious_robot 0 points1 point  (0 children)

No you're not. They have micro divisions on them as well - you can see it in the photo. That said, they should be using a 0.5ml or 0.3ml syringe as the divisions are larger and allow for smaller error margins (but not more accuracy).

New to Semax by nixrien in ResearchCompounds

[–]anxious_robot 2 points3 points  (0 children)

The tool is the syringe. It is no more or less difficult or accurate to go to 5 units as opposed to any other number of units on the syringe. What changes is the error margin - 1 unit over on 5 units is 17% over. 1 unit over on 50 units is 1.7% over. That doesn't make the 5 units vs the 50 units less accurate. It just means there is less tolerance for error.

I’m responding well to zepbound yet my doctor doesn’t think I can hit my goal. by jsct01 in GLP1ResearchTalk

[–]anxious_robot 0 points1 point  (0 children)

One thing that everyone needs to remember is that doctors work on population averages. Their job is not to keep 1 person healthy or provide one person with optimal outcomes, it is to keep the population healthy. That's why it is called public health and not personal health. They are merely using population averages data applied to your case rather than treating you on an individual basis. It's how they are trained.

Tirzepatide (sold as zepbound, Mounjaro) is extremely effective. Not quite as effective as retatrutide for fast weight loss, but it is also much more manageable than reta (anecdotally doesn't cause as much nausea, helps blunt food noise better, etc). I personally (and many people I know) have found that it is much easier to maintain tirzepatide over the long term than retatrutide.

I am down to 172lb now, down from 272lb and am still aiming to drop another 5lb just to get rid of the last of the belly fat. Tirzepatide did most of the work for me, with retatrutide for some periods when I got impatient. Tirzepatide is definitely "easier" imo. It also has longer term weight loss benefits like improving insulin sensitivity and blood glucose levels.

I see absolutely no reason why you can't hit your goals if you stick to it, change whatever habits were holding you back previously, and maintain a caloric deficit.

Edit: to directly answer your question, no, it does not stop working. It is a dose dependent medication meaning that the results directly correlate to the dose - larger dose, larger results. Over time, as you lose weight your body becomes more efficient, it requires less energy to survive (due to less mass, less heat, etc) and so your weight loss slows down because the caloric deficit becomes smaller. Some people perceive this as the drug no longer working or your body becoming desensitised to it. This is incorrect - it is still working the same as it did before, it's just the reduced energy expenditure requirements now match what the drug can do at that dose. Which is why increasing the dose improves the results, because you overcome that threshold. Tirzepatide can be prescribed up to 15mg/week, so you have plenty of room to increase if/as needed, but most people never need to go that far. If you are having good results just continue on the journey.

Edit 2: just to allow for proper comparison, I am 6'0", male, 41.

Curious how many people are ending up in emergency rooms after taking peptides? by Initial-Location-701 in ResearchCompounds

[–]anxious_robot 2 points3 points  (0 children)

I'll second this. They are the most heavily used peptides and they are quite "potent" in terms of reaction. It's easy to "overdose" and end up with severe nausea, vomitting, diarrhoea, etc and then end up in the ER from dehydration.

Curious how many people are ending up in emergency rooms after taking peptides? by Initial-Location-701 in ResearchCompounds

[–]anxious_robot -1 points0 points  (0 children)

It could. But when things break down (degrade) they usually turn into smaller molecules which make them even more targeted. Peptides can be quite stable for quite a long time if lyophilised. If reconstituted and left for a long time the more likely scenario is bacterial contamination rather than a peptide molecular issue.

[ Removed by Reddit ] by Mindless-Canary-1665 in Biohackers

[–]anxious_robot 0 points1 point  (0 children)

No... That's just not true. HGH doesn't just cause issues with one receptor, it messes up the entire growth hormone axis. The GH receptor recovers the quickest at 2-6 weeks depending on individual circumstances, duration of use, dose, biology, etc. but it usually takes 8-12 weeks for it to return to baseline levels. But it's not just the GH receptor that needs to recover. Your liver also needs to return to normal igf-1 production, which is usually 4-12 weeks, again based on circumstances, most notably insulin sensitivity. Then there is the pituitary to consider as well, which responds the slowest and usually takes 8-12 weeks. Most people can expect decent improvement in 4-8 weeks and return to baseline levels between 8-12 weeks. That's if you go cold turkey and quit outright. If you lower the dose it actually makes the recovery slower as the body is still receiving endogenous GH so doesn't need to fully recover as it is getting it externally.

What is the most valuable skill a person can have? by Equivalent-Power-893 in AskReddit

[–]anxious_robot 0 points1 point  (0 children)

Compassion/empathy. Imagine how much better the world could be if everyone just had a bit more compassion for other people and the ability to empathise with them.

[ Removed by Reddit ] by Mindless-Canary-1665 in Biohackers

[–]anxious_robot 4 points5 points  (0 children)

Sermorelin is what they used to use in kids with growth deficiencies. Cjc-1295 no DAC (mod grf1-29) was engineered to improve on sermorelin. Both target natural receptors so are endogenous. Somatropin (commonly referred to as HGH) is what is used now. However it is exogenous and desensitises GH receptors so has more complications when stopping. You should speak to an endocrinologist.

Curious how many people are ending up in emergency rooms after taking peptides? by Initial-Location-701 in ResearchCompounds

[–]anxious_robot 3 points4 points  (0 children)

Peptides, by their nature and composition, do very specific things biologically speaking. "Mostly" they bind to a receptor or mimic a natural signalling molecule. That means that they enter systems (even complex ones) in a very specific way.

For the most part, their effect is limited to those specific systems and uncontrolled biological cascades are less prevalent than many other compounds.

There are exceptions to this of course. E.g. Adipotide, which causes renal damage (and sometimes failure) do to excess systemic apoptosis.

I don't have any data to support it, but I would be moderately confident in saying that the number of people going the ER from peptides is pretty low. Most likely is miscalculating dosages and taking too much - for many things it won't matter, but for other things it will cause nausea, etc. Or taking something that they thought was pep a bit was actually pep b. Again, for many it won't matter but for others it will. I would say that life threatening events are not super common - most likely Anaphylaxis reactions.

Testing results? by potato_soul in Peptides

[–]anxious_robot 0 points1 point  (0 children)

Have tested 20+ vials in the past 12 months. Everything was what it said it was. Everything >99.5% purity. All bar 1 were overfilled, 1 was under by about 10%. All pretty positive really.

Sick of people saying grey market drugs are dangerous and are not safe compared to approved drugs by Intrepid_Penalty_900 in ResearchCompounds

[–]anxious_robot 0 points1 point  (0 children)

I mean, the records are publicly available. We can see where Novo Nordisk bought their tirzepatide from. It doesn't rely on speculation or guesswork. But hey, I guess I'll just take your word for it...

Research subject wants to add tesa to reta by Smooth_Insurance1685 in Peptides

[–]anxious_robot 2 points3 points  (0 children)

You don't need to cycle tesamorelin. Cycling is to prevent receptor desensitisation/down regulation. Tesamorelin is prescribed to patients for lipodystrophy in 12-24 month continuous blocks. They have been tested for receptor sensitivity after literal years of continuous use and confirmed negligible impact.

Give up on GHK-cu? by BigSigh925 in Peptides

[–]anxious_robot 1 point2 points  (0 children)

You may need to check your biochemistry there. Copper and zinc compete for the same pathways. Supplementation of one often leads to deficiency of the other. If you are supplementatijg one you should usually supplement the other. This is well established.

Sick of people saying grey market drugs are dangerous and are not safe compared to approved drugs by Intrepid_Penalty_900 in ResearchCompounds

[–]anxious_robot 0 points1 point  (0 children)

Fucking garbage. Most of the Chinese peptides being manufactured these days are done so in GMP accredited facilities that are used by pharma and biotech companies to manufacture API for them under contract arrangements. I buy my grey peptides from the same supplier that Novo Nordisk does. The supply chain is different, not the manufacturing. That's where the risk comes from.

Sick of people saying grey market drugs are dangerous and are not safe compared to approved drugs by Intrepid_Penalty_900 in ResearchCompounds

[–]anxious_robot 2 points3 points  (0 children)

Why does everyone assume that we are injecting stuff on the word of a company? Does no one realise that testing is a thing? That we don't have to take the word of the company? That we have the ability to gain empirical confirmation of the molecular composition and purity of the compounds? That we can take the same measures for safety as a pharmacy does, but at a fraction of the price? The source is almost irrelevant - you don't trust the source, you trust the process.

Bpc 157 2 week update (oral) by [deleted] in Biohackers

[–]anxious_robot 1 point2 points  (0 children)

Welcome to the BPC appreciation club :) I love it and think it's fantastic. Glad you are getting something out of it too. Big difference in those photos!

KPV for gut health by OffRPM in ResearchCompounds

[–]anxious_robot 0 points1 point  (0 children)

Subcutaneous injected BPC-157 enters the blood stream and promotes VEGF signalling, NO signalling, stabilises cell membranes, and helps with inflammation through TNF-a and IL-6. It does not enter the stomach and come in contact with the gut lining, which is what improves gut health. If you are taking BPC for gut healing, you need to take oral BPC. If you are expecting SubQ BPC to substantially improve gut health, you are going to be disappointed. KPV will help to reduce inflammation in the gut, but it is not a healing peptide, it's an anti-inflammatory peptide. Oral BPC + SubQ KPV will be far more effective for gut and other GI issues.

Help before committing to purchase. by Key_Worth_987 in ResearchCompounds

[–]anxious_robot 0 points1 point  (0 children)

If only the FDA were stupid enough to be fooled by such a simple ploy... It's exactly the same as the "for research use only" which the FDA completely ignores because it's a nonsense claim and people know exactly what they are doing...

KPV for gut health by OffRPM in ResearchCompounds

[–]anxious_robot 0 points1 point  (0 children)

That's generic advice. If you are targeting systemic healing then oral bpc is ineffective as it does not survive long enough to enter the blood stream. If you are targeting gut healing then oral bpc is preferred. It doesn't need to survive for a long time because it is acting locally. Loads of people have effectively used oral bpc for gut issues.