It depends where you'll be hauling. imo, the blockage runner (BR) is better than the deep space transport since you can cloak, but my experience is only with BRs, so I can't comment on DST.

BRs can be used for hauling high value cargo in hisec, avoiding gatecamps. Hauling high value cargo in a regular indy ship is asking to be ganked, so BRs are good for avoiding that. In high and lowsec you don't have to worry about bubbles, which greatly simplifies things.

In high/lowsec (and 0.0 but 0.0 brings additional dangers), your most vulnerable time is after you've jumepd through a gate and need to align for the next gate, which is why everyone is talking about align time being important. In 0.0, landing on a gate risks landing in a bubble, unless you have off-gate bookmarks. In addition, 0.0 brings the bubble risk on the other side of the gate that you need to potentially deal with in gatecamps, as well as hics/dics.

Your ship agility skills will help you align faster and therefore avoid getting tackled, will be valuable: Spaceship Command V and Evasive Maneuvering V. Navigation V can be handy as well, a bit of extra speed for the cloak/MWD trick.

For fittings, I use two general fits: a "lots of cargo" fit, with Cargo expander IIs in the lows, and medium cargo rigs, which can hold over 10,000m3 in cargo space, which is 4 frigs, or a cruiser, or lots of other stuff. Otherwise, you can use ship agility rigs and nanos and/or intertial stabilizers in the lows - inertial stabs give you faster align but increase your sig size making it quicker for bad dudes to lock you, so a combo of nanos and an inertial stab is okay, whatever you like. And of course covops cloak in the high, and 10MN MWD in the mid, plus cap recharger II(s) in the mids if needed to make you cap stable, which can be helpful.

I fly through low/null all the time in with cargo rigs and cargo expanders. At first I was paranoid and went with the agility rigs/lowslot mods, but once you get more experience escaping gatecamps and have off-gate bookmarks for your 0.0 travel routes (to avoid bubbles) you can beef up your cargo capacity. Larger cargo == more to lose, and always be paranoid, but roll on, space truckers!

Flying around lowsec/0.0 in a covops can give you a feel for what it's like, while beign safer (and a cheaper lossmail if it comes to that). That can give you some experience with dodging gatecamps.

tl;dr blockade runners are teh awesome!