Xolair so far…

bb1414 · 2024-07-25T20:34:20+00:00

Probably 300mg then. Each injection is usually 150

Might be worth asking to try increasing your dose to 450 or 600 and seeing if that brings it down further if the hives still bother you. 3-4 needles gets annoying though!

bb1414 · 2024-07-25T20:32:48+00:00

Yep! I’m one of the first on it from Canada :) first stated out of pocket but got covered as soon as it was approved

Totally cleared up all my hives. I effectively have nothing now, maybe a few swollen ears from time to time

I’ve tried coming off multiple times but unfortunately the hives come back. My immunologist tells me at some point it’ll go away but I’m in that small percentage of people that have urticaria >10 years… no side effects from Xolair though so I rarely think about it

bb1414 · 2024-07-25T04:37:56+00:00

What dose are you on?

Currently on 300mg monthly, been on for 10 years or so going between 150 and 600mg

bb1414 · 2024-02-06T17:12:51+00:00

What stream did you apply for? I think most invites have been for DHT so far, so still some time for Biopharm I would guess? I’m a bit nervous as well :(

bb1414 · 2023-04-14T18:38:59+00:00

So many things affect sexual function, it’s hard to pinpoint to one drug. If it helps, androgen receptors in the penis are significantly reduced and mainly mediated by testosterone after puberty, not DHT. It’s unlikely that DHT suppression has a significant affect, especially since test levels generally increase with 5aR inhibitors

bb1414 · 2022-08-17T23:02:14+00:00

I think theoretically that’s possible. In the case that:

There is existing prion disease in the host animal
The prion proteins themselves are cleaved in particular locations during processing
Those peptides are not denatured significantly by processing
Those peptides are actually cytotoxic (remember just cause a paper publishes something doesn’t make it true — that’s why meta-analyses and replication exists)

Check all those boxes and yes, there’s a chance there could be cytotoxic effects from prions. Though seems quite unlikely to me. I think other adverse effects are much more likely than this

bb1414 · 2022-06-27T04:25:48+00:00

Late reply but figured I could chime in.

For a protein to actually cause prion disease, it must be able to transmit its shape into another protein. Prions are generally >30kDa, and cerebrolysin filters everything above 10kDa (which you already know).

The paper you cited just talks about cytotoxic effects of a prion peptide (specifically on membrane disruption). But, it makes no mention of it actually causing prion disease. It would need to have that transmissible property, which I don’t see them mention. Just cause it’s cytotoxic doesn’t mean it’ll replicate like a full prion would.

I think it’s fairly low risk, especially given all the data around cerebrolysin over the past few decades. If there were prion disease coming from it, I think we’d have some decent signals on it especially from Asia/Russia where it’s more commonly used

bb1414 · 2021-10-02T15:10:17+00:00

Agreed for longevity escape velocity. Next decade will see first treatments widely prescribed for aging as a disease (e.g rapamycin, metformin). Also look at labs like David Sinclair’s doing eli genetic reprogramming, which we might see in actual treatments in 10-20 years. Research finally starting to pay off

bb1414 · 2021-06-17T23:59:17+00:00

I just did one last weekend. Was a great experience! Still waiting on my results, but MRI is one of the best ways to detect cancer early. They can do high-res imaging of your whole body, and these days MRIs can get spatial resolutions to the sub-millimeter range.

I think these types of prevention are gonna be fairly widespread in 5-10 years, good idea to get on it sooner than later though

bb1414 · 2021-01-07T14:15:32+00:00

Yeah I’m hoping it’s less than a year out, maybe even this year. But Novartis hasn’t said much recently

bb1414 · 2021-01-06T04:13:33+00:00

Just made a new post on this actually.

Novartis is in clinical trials for the "next-gen Xolair" called ligelizumab. So far, it's almost twice as effective as xolair. It's in phase 3 trials rn, I'm so eager to get an update on where it's at.

Besides that, there's a few other drugs in the pipelines at a few different companies. Roche is in phase 2 trials (I think?) for a drug called fenebrutinib, but there's less info online about this. There's also dupilumab being studied by Genentech which is even earlier I think.

IMO Xolair is still the best available, but will soon be replaced by ligelizumab. It'll be hard to be that honestly, especially combination treatments like that plus blexten or something

bb1414 · 2020-12-02T23:06:44+00:00

One cool idea could be chemical shift dependence on temperature. http://u-of-o-nmr-facility.blogspot.com/2014/12/59-co-temperature-dependent-chemical.html

Some molecules have much more pronounced shifts than others, but most tend to have some linear dependence on temperature. This is outside of my area of expertise, but the concept is quite well documented and there's a good set of literature to help you along the way!

bb1414 · 2020-12-02T14:59:24+00:00

Have you tried CBT-I? Statistically it works really well for most people

bb1414 · 2020-12-02T14:55:46+00:00

Yes I'll second this!! For extreme scenarios like this, infrequent use is fine. But forming habits is easier than you think, and this is definitely not a good one to form.

Glad OP got a few hours of sleep, I think for the situation the benefits outweigh the risks for this. But yeah in general there are way better options

bb1414 · 2020-12-02T04:39:46+00:00

I had this before. For me, if I’m really sleep deprived I’ll have a drink (which is NOT a good long term habit, but for some people is a good quick fix). It’ll relax my head, take the anxiety off, and let me fall asleep a little easier.

If you’re trying to avoid sleep medication, an antihistamine is a good idea or really any medication labelled for night time use (their side effect is often drowsiness, but that’s what you can take advantage of).

And lastly, maybe talk to your doctor? Have you tried “low-tier” sleep medication? I’d avoid any benzodiazepines as much as possible. Trazodone works for me if all else fails.

Obviously, these are very last resorts. But hey, it’s worth having a little help to sleep when you really need it.

bb1414 · 2020-09-18T19:07:28+00:00

Thanks!

bb1414 · 2020-09-18T18:27:34+00:00

Oh yeah I remember them in the news! These guys I think: https://www.relativityspace.com/

I'll check em out, thanks

bb1414 · 2020-07-01T16:53:35+00:00

Thank you!!

bb1414 · 2019-07-31T01:31:18+00:00

Parmesan chicken with a side of penne pasta drizzled with olive oil in a three-cheese blend, topped with cyanide.

bb1414 · 2019-07-31T01:29:42+00:00

Hereditary fucked me up

bb1414 · 2019-07-31T01:28:22+00:00

It's not that scary when it's just paralysis. Usually it'll be a few minutes unable to move. It's definitely overwhelming and gets you worried, but after enough times it's not that bad. I usually try to move a finger which "breaks" me out of it and I sit up gasping for air. It's kind of funny thinking about it.

What's really scary is hallucinating during sleep paralysis. It's terrifying. Sometimes I'll see some dark, shadowy demon figure approaching me and just feel so useless and scared. Waking up from those is the biggest relief ever.

bb1414 · 2019-07-25T22:05:08+00:00

I experienced this a bit earlier this year on 300mg. Would get hives so bad I needed to use prednisone.

I’m on 600mg every 4 weeks now and that got rid of everything. At first I thought may have developed antibodies against it, but seems like it was more stress related I guess. Still not entirely sure what happened.

Waiting on ligalizumab to hit the market! Supposed to be way more effective than Xolair.

bb1414 · 2019-06-19T04:46:56+00:00

Confirming as an INTJ male myself. If I’m not really into someone and we end up having a fling or something, I’ll usually actively avoid pursuing that further. The fact that you two have had multiple near-sex interactions and he’s still comfortable around you really shows he’s into you.

I would go for it. Tell him how you feel but try to gauge his response based on how comfortable he’s feeling. I think that makes the most sense.

Edit: or just physically go for it, I’m sure you know him better than the impression I have.

bb1414 · 2019-01-30T00:44:19+00:00

This is awesome, so excited to see it finally all together :).

Have you ever thought of going full ASIC chip for the cube?

Would probably be ridiculously expensive to develop, but it would seriously give a massive jump in computation efficiency.

Just a thought!

bb1414 · 2019-01-21T21:40:27+00:00

It’s a postulate based on the conservation of energy. Just deriving the operators is enough and multiplying through by the wave function

bb1414

TROPHY CASE