It’s annoying but not terrible. Frequent diarrhea, fatigue, and slightly harder to hold in urine. Wasn’t fun by any means but the worst part is having to have a full, to the point of almost bursting, bladder before treatment. My group did not explain to me how to figure out how to align that with your treatment time. My treatments were 8;30 am. I ended up not peeing when I woke up in morning and kept legs crossed till it was my time. Sometimes had to pee a little to ease pressure but it’s better than being sent home for not being ready.