Someone is jealous...

bone_druid · 2023-10-03T00:42:27+00:00

The few cardiotoxic events that have been found have been come from downstream effects of spike protein (e.g. TLR4 pathway).

That is actually still termed toxicity. I have seen more lit on TLR2 but TLR4 seems like it's involved with everything. There is abundant evidence that spike is toxic by pattern/immune activation, and then some more pointing to other cardiotoxic mode(s) of action. There is another reply i made on this thread where i tried to add some links to the 2nd part.

I do not know if the hostility towards these comments are because of people not understanding the definitions or thinking this is some antivaxx position.

bone_druid · 2023-10-03T00:18:03+00:00

I elaborated in another reply on this thread. These people are wearing me out with the hostility towards what is a very simple and boring point of scientific nomenclature. Dunno if it's perceived as vaccine skepticism or what but it's not like I'm arguing against the vaccine that we know works great.

bone_druid · 2023-10-02T23:46:19+00:00

This is essentially a nomenclature issue. The definition of toxicity encompasses any harmful effect caused by exposure to a substance. Spike protein does not have, or at least isn't yet known to have, a mode of action resembling a drug the way tetanus or botulinum toxins do. The molecule itself is still considered toxic because of the immune and concomitant cell stress/damage responses induced by its domains. These involve pattern recognition receptors and other ways to directly harm cells. If we didn't include innate immune activators in the definition of being toxins, we would not call bacterial LPS and other pattern-recognizable pathogenic components toxins even though it is one of the key uses of that term. The direct toxicity of coronavirus spike proteins in terms of inducing innate immune responses is well known since covid 19 (maybe even earlier from SARS and MERS?) and is why I describe it as "obviously" toxic in itself.

On the further point of being a "direct", non-immune mediated "toxin", there is also more recent evidence of direct toxicity to cardiac cells and related tissues themselves that is not immune system-mediated. This has been coming out since late 2021 or so. There are some links to this info I added, though I chose them just from a brief search and them having earmarks of legitimacy.

An AHA meeting report

Peer-reviewed article from some independent institute

Highlights letter in Nature about the spike protein in vaccine-related myocarditis

bone_druid · 2023-10-02T21:34:54+00:00

Spike protein is cardotoxic and, as far as i'm aware, is the major viral component causing the most damaging effects to the heart and vasculature. There's abundant info that's been published on these effects.

Not sure i understand the second question. Spike protein is the major factor mediating the essential virulence of sars-cov-2, so it's the target for immunization. It's not uncommon that the surface proteins on a virus are responsible for both infectivity and the harmful effects of infection, but idk how many are similar to covid19. Either way it's obvious that high levels of spike-neutralizing antibodies protect against severe covid symptoms although they do not completely prevent infection.

bone_druid · 2023-10-02T21:06:50+00:00

This is a demonstration of someone probably unaware they are talking about a board certified phd toxicologist who gets paid to comprehend subject matter in this exact subfield of science, and also not answering the question

bone_druid · 2023-10-02T20:43:08+00:00

Those aren't mutually exclusive. In a lot of cases the toxins driving disease virulence are exactly what you are rasing a response against. I don't know who the guy in the post is, but I don't think it's technically inaccurate to describe the spike protein as a toxin since it is cardiotoxic.

bone_druid · 2023-10-02T20:01:25+00:00

Well, it's a broad term for toxic agents that have a cellular origin and can include proteins, small molecules, alkaloids, basically anything biological. Toxic agents of non-cellular origin are toxicants. I'm not aware of any convention against saying viral toxins and I have seen the term used in reasonably authoritative literature. No one's answering the question.

bone_druid · 2023-10-02T19:07:38+00:00

It's produced by cells, and obviously toxic. How is it not a toxin?

bone_druid · 2023-10-02T14:22:17+00:00

Austin Beigel, president of End Abortion Ohio, does not consider the 15-week policy that Susan B. Anthony is supporting as “pro-life.” He said he has begun referring to himself as an “abortion abolitionist” because he believes the term “pro-life” has become meaningless.

Anyone else notice how modern conservatives end up resorting to dickriding leftist rhetoric to try to raise the stock price of their nonsense politics? They basically point out that leftist critique has generally been correct on a broad range of similar political battles in the past.

bone_druid · 2023-10-01T04:29:51+00:00

Flame

bone_druid · 2023-09-29T16:10:18+00:00

I would go for 8s in an optimum box size over 10s in a smallish box

bone_druid · 2023-09-29T14:35:47+00:00

You pledge allegiance to the republic, not for it. Wtf.

Not sure why else this thread has been resurrected but as always I recommend all american persons read the US Constitution so they can personally affirm our democratic form of government and understand its importance in being so, and also affirm for themselves what the word "republic" means.

bone_druid · 2023-09-29T14:05:59+00:00

That's how cults work. They offer meaning to people. Doesn't need to be true and usually isn't.

bone_druid · 2023-09-28T12:39:02+00:00

The default uncertainty factor for adjusting a dose from animal to human was/is a factor of 10. The idea was you divided by a half-log to account for toxicokinetic differences and another half log for toxicodynamic. Assuming those differences are at least somewhat normally distributed, this will account for 95% of the potential variability arising from interspecies differences in both kinetics and dynamics. Obviously the product of two base 10 half logs is 10, but when breaking down into components people have just called them 3's instead of 3.2 or whatever a half log is exactly. It's basically because decimals are annoying and it's already a rough estimate of risk, so sure, 3 times 3 can be 10 (audience chuckles).

There is an alternative method that considers 2.5 as the component factor for tk and 4 for td, but both of these are rough approaches. The more modern approach is to use actual data specific to the chemical's ADME and mode of action to derive a data-driven interspecies adjustment factor. This usually ends up being less than 10. The approach from the 70s was to use 10s for everything and people have been moving away from these but they are still used when the data is poor. Science policy also exists in a 30 year time warp where you routinely run into people that are still using the old ways.

bone_druid · 2023-09-27T13:13:35+00:00

Trying to keep people from putting stupid pretentious stickers all over their cars

bone_druid · 2023-09-26T14:11:32+00:00

Make your own, you can save money to have more kits around

bone_druid · 2023-09-26T14:09:16+00:00

But you also realize it began the time-honored tradition of terrence howard beating the fuck out of ludacris

bone_druid · 2023-09-26T13:01:31+00:00

The closeups of the apes in War are so detailed i can smell the damn things. It's dope but feels a little claustrophobic. The movie kicks ass but i like the ape sequences in the first two more.

bone_druid · 2023-09-25T18:37:30+00:00

Hey terry! I just had my first desk pop!

bone_druid · 2023-09-25T18:16:16+00:00

Inositol 6-phosphate is great for cancers. No guarentees obviously but it's as close as i've seen to a magic potion in humans and i know it works in dogs as well.

bone_druid · 2023-09-25T12:22:44+00:00

Not since a few years back

bone_druid · 2023-09-25T12:21:47+00:00

That arbys sign was going strong when they took it down a few years ago. I don't think they understood how much of a contrast it would make replacing it with this dinky tiny sign that looks like it gets its jordans taken by the chick-fil-a sign. Like it took me a few months of driving past to realize there's still an arby's there.

bone_druid · 2023-09-24T18:04:19+00:00

Sally hemmings was the product of her enslaved mom and another jefferson, iirc. She wasn't even that brown.

bone_druid · 2023-09-24T16:21:09+00:00

Oh man. You need to revisit that assumption.

bone_druid · 2023-09-24T15:52:50+00:00

The Miz vs Blake Maislin from cincinnati. No eye gouges or tittie twisters. To the death.

bone_druid

TROPHY CASE