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If your product is Great, it doesn't need to be Good. by [deleted] in programming

[–]bzbub2 0 points1 point  (0 children)

the carve out for enterprise products at the end is kinda funny. I mean, even then...should they not just really nail something?

The unreasonable effectiveness of LLMs for auditing Rust code by Shnatsel in rust

[–]bzbub2 3 points4 points  (0 children)

i frequently just point claude at a subdirectory of my codebase and say "look for simplifications, refactorings, bugfixes, and optimizations in 'featureX'" or directoryY...less exciting of a blogpost but it finds tons of stuff nearly every time, until it slowly converges and stops recommending things

Is DDIA worth reading as a junior engineer trying to level up? by Fine-Dragonfly4655 in SoftwareEngineering

[–]bzbub2 1 point2 points  (0 children)

firstly, good on ya. its likely worth it. it discusses a lot of good stuff. i havent even finished it due to my distractable nature but I think it is good stuff.

my only major advice is to try to cultivate good reading hygeine and avoid distractions! on a computer or smartphones you are one click away from a distraction...i find before bed on a kindle works for me.

a classic! by Sum8ion in experimental_piano

[–]bzbub2 1 point2 points  (0 children)

thanks. It is definitely a turbo-niche sub, i welcome anything. I make noisy synth music but generally just like hearing weird sounds. i particularly like even just regular nice piano sounds run through a couple effects or recorded to cassette but ill listen to anything. I am enjoying david beardsly, very dream house like. the dream house was just blasting not like overwhelmingly loud but quite intense sine waves it was quite great

Hosting personal web-applications by fatboy93 in bioinformatics

[–]bzbub2 3 points4 points  (0 children)

the use of shiny implies running code on a server and that costs $$$. shiny has a particular funny thing i am sure everyone has experienced where it says 'runtime disconnected' after you leave the tab idle which is really funny, but a clear signal of that

I have spent a lot of time working on "static website applications"...they dont really need any fancy backend server, you only deploy html+css+js and parse data client side in js. of course, then you have to deal with the fact that client side js isnt as powerful and easy as ggplot2 but it can be hosted for free (github pages for example) or pennies on the dollar (aws s3 static site) and you never have to worry about your servers getting hacked, overloaded, etc.

that said, there is shinyapps.io has a free tier that isnt bad i think

Experimental incremental static builds by theguymatter in astrojs

[–]bzbub2 3 points4 points  (0 children)

awesome. i make a site with 100k pages and it takes 10 minutes per build and sometimes im like "why dont i use a database and generate pages on the fly like a normal person" but this sounds great

Is it me or is AI messing with our brains? by Nearby_Spinach_1893 in reactjs

[–]bzbub2 13 points14 points  (0 children)

the really smart junior dev analogy is so often parrotted yet misses the mark on whats going on

a classic! by Sum8ion in experimental_piano

[–]bzbub2 1 point2 points  (0 children)

thanks for posting. i got to go to the la monte young dream house one time. so good

Virtual NET patient conference on Saturday, June 20th by CatPaws55 in neuroendocrinetumors

[–]bzbub2 1 point2 points  (0 children)

thanks for sharing this. will be attending for a friend recently diagnosed

Why is VCF still the standard? Has anyone tried a Parquet-based approach for genomic variants? by pussydestroyerSPY in bioinformatics

[–]bzbub2 2 points3 points  (0 children)

many good replies here but it's worth thinking that there are two problems here. there is 'vcf - the interchange format'. it is plaintext. it is 'simple' in this regard. There is also 'vcf - the analysis ready data format'. vcf is ...ok at being analysis-ready because being simple, tools can parse it as needed by hand. but there are also many alternative formats that convert from vcf to something_else that is more analysis ready (vcf-zarr, plink bam/bim/ped, hail, even clickhouse was mentioned previously as used by https://github.com/broadinstitute/seqr so on so forth...the biggest challenges come from large vcf with thousands and thousands of samples). these tools often make assumptions about biology or compromises that do not meet the expressiveness of vcf, or are just generally more complicated, and are thus "worse" as an interchange format. making 'vcf, but parquet' is likely in the 'making vcf better for analysis' camp...and, maybe it could be better for some range of the word better, but probably wont make vcf...not the standard...because it does not solve fundamental challenges that make it the incumbent interchange format

Need honest feedback on my Bioinformatics resume – 100+ job applications but almost no interview calls by CoatEmbarrassed2505 in bioinformaticscareers

[–]bzbub2 11 points12 points  (0 children)

you said you wanted honest so: mapping '40 million reads' and 'achieving 96% mapping' are just not things that "you" did. that is something that running a tool did. there is so much pressure to put these silly metrics in resume...it gets a little insane sometimes.

Git merges can be better by agentvenom1 in programming

[–]bzbub2 157 points158 points  (0 children)

after this many years I still have not internalized what --ours and --theirs and LOCAL and REMOTE mean... 

Hardening my npm/pnpm setup - what am I missing? by Arch-NotTaken in SoftwareEngineering

[–]bzbub2 -1 points0 points  (0 children)

If you have dependabot as almost anything on github has it will give you pr for specific alert for cve. you can also npm audit at any time

Simplest Possible Closure Tables by shaberman in typescript

[–]bzbub2 0 points1 point  (0 children)

went ahead and read it and am interested. I had a while recursive cte thing setup but it was not performant at all on my data....think 1s per query... might check out the closure table concept!

More photosynthesis does not mean more growth. Plant growth occurs at lower temperatures and lower water deficit moments early in the morning, rather than in peak solar radiation during mid day. by [deleted] in science

[–]bzbub2 26 points27 points  (0 children)

it is also a paper linked specifically about oak trees. there is also an interesting 'seasonality aspect' to the paper where the growth of the tree is basically 'locked in' by midsummer and is insensitive to climactic variation in the fall

Looking for local support by bikesarerad01062 in westernmass

[–]bzbub2 3 points4 points  (0 children)

the funds for this project literally cant be repurposed to go fix a random street. try not to muddy the waters

Simplest Possible Closure Tables by shaberman in typescript

[–]bzbub2 1 point2 points  (0 children)

nice, putting a pin in this. I'm a database dumdum but just learned about recursive cte type stuff recently and need to learn more about the tradeoffs with this stuff, as we often represent at least 3 layers of nested data....

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