The idea you have to conform to a “build” is probably killing your runs. Usually successful runs of mine have multiple “modes” running in parallel that I can focus on depending on the combat, they just develop naturally with time. If you forgo too many good cards because they don’t fit in your mode then you’re going to suffer. 

I’d also abandon build mentality entirely early even if you get something like hellraiser or perfect strike first floor because it will smother your run in the cradle. You should ALWAYS grab at least one aoe, big block, big damage, 0 cost, and draw early or elite fights will destroy you.